Nothing enters an uncharacterized window. Each return names its own gate.
Ferrous bisglycinate 36 mg elemental, alternate days, 6:00 AM fasted. No gate remained: ferritin 10, TSAT 4%, CRP 2 — the measurement this was always waiting on came back on 8/17 and it is unambiguous. Started ahead of Wancata's route answer, deliberately ⟨N⟩, so something is happening while oral-vs-IV resolves.
🆕 Dose history ⟨N 9-17⟩: raised to 72 mg (4 caps) on 9/03, split 2 + 2 across the morning on 9/15, and back to 36 mg at 6:00 AM on 9/17 — reversal trigger (a), a dose-graded, iron-day-only intolerance. This card went unchanged through the 72 mg period; its dose line is accurate again as of rev 7.75.
🆕 9/21 — IRON HELD ⟨N 9-21⟩: the draw is 9/22 and the IV iron 9/23, 7:30 AM. Trigger (b) retires oral iron when the infusion course completes; re-entry afterwards is a recheck decision, not before 5 days after the last dose. The 9:00 AM drink stays on (b) and EGCG waits to ~10/1 — both offered, not adopted. The note below is kept as history; its “~8/21” was a forecast.
🆕 9/23 — EXITED ⟨N 9-23⟩: INFeD 1,000 mg, one total-dose infusion, no premeds — trigger (b) fired. Both 9/21 offers accepted: the 9:00 AM drink stays; EGCG waits for the ~10/1 read (open item 128 bears on it). Re-entry is a recheck decision, ~10/21 at the earliest.
🆕 10/1 ⟨N 10-01⟩: the recheck is ORDERED at Labcorp; its test list and date ⟨?⟩. EGCG did not return anywhere — it EXITED 10/1 (egcg-cut), so its “~10/1” wait is closed. If the recheck says oral iron re-enters, the rules are written in advance — iron-reentry-table, open item 130.
✅ 🆕 Both settled — the 48 h iron skip ran before the 9/22 draw, and the resveratrol cut runs from 10/1 ⟨N 10-01⟩. Historical: ⏳ Two things still queued behind the ~8/21 Kuhlman draw: the resveratrol cut (unchanged — 11 tests form a paired series) and a 48 h iron skip before that draw, so the sTfR/TSAT/retic set stays interpretable. 🔴 The iron dose is a placeholder, not a plan — deficit ~1,272 mg, oral closes it in months. See open item 59 — ✅ CLOSED 8/27: IV ordered by Kuhlman, ferric derisomaltose.
Nothing new enters an uncharacterized window. New additions are easier to read one at a time — but sequence them as you judge best. Single-variable is the default, not a hard law.
| When | What | Behind which gate |
|---|---|---|
| 7/21 | ProBiota HistaminX ✅ STARTED | Meal 1. Attribution window runs to ~8/4 — but it is NOT single-variable: four changes sit inside it, including the agmatine stop on 7/26 — that arm is now closed by re-derivation (7/29) and nothing in this window waits on it. Read any signal before ~8/4 as unattributed. Nothing else new enters until it closes. |
| 8/3 | Eating window ✅ RESUMED | noon → 8:30 PM ⟨N 8-3⟩. The 6:30 AM protein bite is cut; Creon goes PRN; the morning Rx cluster runs fasted. A small transitional snack is fine and informal — no slot. Two evening slots now sit inside the fast (8:45 PM, 9:45 PM) — undecided by design, open item 28. |
| 🔴 8/7 | THE DRAW — Friday AM | Everything that waited on a lab now has a date. Carries the first post-Frey C-peptide · fasting insulin · HOMA-IR, plus Ret-He + TSAT. ⚠ R-ALA, Panax, Bilberry, Saffron, MegaSpore and the NAC bolus are all already on board — this is an on-regimen baseline, not a clean one. Agmatine and Gymnema are held to post-draw to keep at least those two out. |
| 8/7 | Agmatine 1,000 mg · Gymnema 400 mg | Both glucose-active → both start after the needle. Agmatine 4 × 250 at 6:15 AM / 10 AM / 1:45 PM / 5 PM. Gymnema back to 7:45 PM pre-dessert. |
| ~8/1 | Telmisartan 80 mg | All six BP gates, or it holds again |
| ~9/15 | SPM Pro-Resolve ✅ LIVE | 🆕 1 softgel at dinner, with Creon ⟨N✓9-15⟩ — started ~9/15. In master-regimen.md for the first time (rev 7.73), with the first omega-3 total: EPA + DHA 1,425 · DPA 45. Kept at dinner — the case for Meal 1, its larger Creon dose, ended 9/09. ⚠ Started ahead of Kuhlman’s lipid panel and inside the grape-seed watch — annotated, not a hold (open item 123). Ruled 9/15: “already taking it.” |
| 8/5 | MegaSporeBiotic ✅ STARTED | 1 cap, dinner ⟨N⟩. Label-correct — Microbiome Labs directs 1 cap with food, stepping to 2/day at week 3. No change recommended. ⚠ Do not step to 2 caps inside the NAC / Turkey Tail watch: its listed side effects are the same signal those are read on. |
| ~8/11 | Turkey Tail ✅ LIVE | ✅ 500 mg × 2 = 1,000/day ⟨N 8-11⟩ — Meal 1 + Dinner, the pre-surgery placement restored. ND powder or Real Mushrooms cap, same dose either form. ⚠ Stool colour is no longer a usable rebleed monitor — substitutes: lightheadedness · unusual fatigue · resting HR trend · the iron panel. |
| 🆕 ~8/11 | NAC → 3,800 ✅ LIVE | 🆕 Ramp complete ⟨N 8-11⟩. 1,000 at noon + 500 (3 PM) + 500 (dinner) — 3 slots ⟨N 8-26⟩ + NOW 600 × 3 @ 8 PM. ⚠ +500 past the 3,300 target — that increment has no indication on file. 🆕 Overtaken 8/14: open item 37 closed on his stated indication — Adderall smoother, mood better ⟨N 8-14⟩. |
| 8/24 ✓ | 🍄 Cordyceps — LIVE | 🆕 STARTED 8/24 ⟨N✓8-24 · label read⟩ — Real Mushrooms CORDYCEPS-M, C. militaris extract, 500 mg × 2 = 1,000 mg/day, 8% β-glucans. Open item 69 closed. 🔴 1,000 mg is the floor of the studied 1,000–3,000 mg range, and the Cs-4 literature does not transfer to militaris — open item 74. ⚠️ Two written restart conditions unmet: it did not land alone (four changes share 8/24), and it is glucose-active with the Kuhlman draw still pending 🆕 — drawn 9/22; its glucose endpoints are an on-Cordyceps reading. Antiplatelet-adjacent against a healed-ulcer/ferritin-10 background — open item 70. |
| ~8/13 ✓ | 📟 Truvaga Plus — LIVE | 🆕 Live since ~8/13 ⟨N⟩ — this row was eleven days stale. Pre-meal 2-min Reduce Stress sessions; evening wind-down restored 8/20. Protocol lives in truvaga-protocol-v4-1-2026-09-18.html, not here. ⚖️ Resting HR/BP effect not shown for cervical nVNS, and never measured in you — the 8:00 PM reading stays the sentinel. |
| ~7/29 | R-ALA (Na-R-ALA) 300 mg ✅ LIVE | 6:00 AM. Started ahead of the Ret-He + TSAT pair it was sequenced behind; those draw 8/7. ⚠ rev 7.32 never recorded why it was held behind them. |
| ~8/1 | ✅ Berberine Phytosome — LIVE | 🆕 Running since ~8/1 ⟨N 9-15⟩, ahead of this gate — 275 × 2 at 5:45 + 7:45 PM. The gate read: |
| ~7/15 · ~8/2 | Saffron · Bilberry · Panax GS15-4 ✅ LIVE | Saffron 30 mg @ 6:15 AM (~7/15) · Panax 200 mg @ 6:00 AM (~8/2) · Bilberry 100 mg @ 10:00 AM. Meter validated 8/3 — Accu-Chek Guide, Hct 10–65%. Bilberry = LE MirtoSelect 100 mg fruit, 36% = 36 mg anthocyanins/day — 11–21% of every dose where a human glycemic or antiplatelet effect was shown. |
| — | 🚫 MOOT 9/15 — Erinamax left the regimen ~9/8 ⟨N 9-15⟩. Historical: Conditional on information, not time. If ND confirms 0.5% is a floor and the material assays near 1% → no action, one capsule is already ~5 mg/day. If it genuinely assays at 0.5% → 2 caps, alone, single-variable. Also waits on the ProBiota window closing. | |
| 🆕 10/23 | Digest Basic ✅ LIVE from 10/23 — first dose planned for dinner | 🆕 1 cap at each of the four meals ⟨N 10-23⟩, replacing PE Digestive Enzymes Ultra (the rest of that bottle is a reserve). A function match, not like-for-like. Its watch runs 10/24–11/6 (baseline: a usual evening on PE, written 10/23) — 🆕 the morning NAC move follows on Sat 11/7 (its watch to 11/11), then the grape seed and DAO swaps, not before 11/12 and one at a time, none during a Digest Complete watch. Exit rules and the fallback (Digest Complete, 1 per meal): master-regimen.md, Meal 1 · open item 142. |
| 🆕 10/29 | ☕ Coffee + L-theanine 200 → 8:30 · 🍽 L-glutamine at the first bites ✅ LIVE | 🆕 His calls, 10/29 ⟨N 10-29⟩: the morning coffee and its 200 mg theanine move 9:00 → 8:30, together — 9:00 on a sleep-in morning, when the condensed start puts the 7:00 glutamine near 8:00. L-glutamine stays at 15 g a day and the 15 → 5 g step-down is retired; noon and dinner glutamine go with the first bites, from now (he chose now over Thu 11/12). Behind nothing: a habitual drink 30 minutes earlier, and an unchanged dose moved within the same meal — neither should register against the enzyme watch (to 11/6) or the NAC watch (11/7–11/11); the date is logged here in case one does. Every daily total unchanged. master-regimen.md, the 7:00 and 8:30 AM slots · items 86, 87 and 101 closed. |
| 🆕 11/7 | ⏳ NAC — one NOW 600 moves 8 PM → 6:00 AM | 🆕 The move decided 10/24 ⟨N 10-24⟩, for coverage in the morning Adderall hours; which capsule he handed over, on the condition that GlyNAC is unharmed — the 8 PM one, Claude’s call, and the date ⟨N 10-24 · delegated, derived C·10-24⟩. Behind: the enzyme watch (ends 11/6) and no Digest Complete fallback under way; the clean mornings holding (seven in hand 10/24); buspirone settled (~10/29). Day total unchanged at 3,800. Days 1–5 stomach watch, to 11/11 — any signal sends it back to 8 PM. Then grape seed and DAO from 11/12, one at a time. master-regimen.md, NAC section · open item 143. |
| Agmatine 1,000 mg — RETURNS 8/7 | ✅ REINSTATED ⟨N 8-6⟩ — on stated subjective benefit, NOT on the burden rule. The rule's premise fails for this item specifically (the original add was ⟨C⟩, April 2026, on an ASD plasma-agmatine association), so using it would launder a ⟨C⟩ artifact into a justification. Nate wants it; that is his own observation and a non-circular reason. All four old reopen conditions are overridden or dissolved. Safety searched directly 8/5: the polyamine-depletion worry is in-vitro, non-pancreatic, zero in-vivo pancreatic demonstration; a rat cerulein-AP model found agmatine protective (rodent, injected — a datum, not an indication). ❌ Not checked: agmatine ↔ amphetamine. Rodent sensitization literature exists and was not opened. |
| Gymnema 400 mg — RETURNS 8/7 | ✅ RESTORED ⟨N 8-6⟩ to its original 7:45 PM pre-dessert slot at its original dose. Removal premise postprandial-fall is falsified (paired delta +3.4 mmHg). Glucose-active → holds to post-draw. ⚠ Confirm 400 mg against the bottle. |
| Berberine 275 mg BID — LIVE ~8/1 | ✅ 🆕 Recorded 9/15 ⟨N 9-15⟩ — restarted ahead of its gate, at its established 550 mg/day. Was: HELD 7/10 · strongest independent systemic case · BP/anemia gates, not hypoglycemia. |
| L-Citrulline — CUT ⟨N 8-6⟩ | 🔴 And unlike Gymnema, there is now a real case against it. The old removal reason was falsified — but a better-grounded one replaced it. Meta-analyses of oral L-citrulline show systolic −4 to −7.5 mmHg and diastolic −2 to −3.8 mmHg ⟨PMID 30206378, n=424, 15 trials · PMC6933755, 14 trials · 2025 meta, n=415 middle-aged/elderly⟩, with effects largest in those already on the low side. You are holding telmisartan at 40 mg precisely because diastolic keeps hitting the <55 stop rule. Adding a nitric-oxide vasodilator is the wrong direction. Cutting it is well-founded — no reason to reconsider. ⚠ One honest caveat: diastolic effect was significant only at ≥6 g/day in one meta, so a low dose might be inert — but "might be inert" is not a benefit. |
| Chromium — CUT ⟨N 8-6⟩ | ⚪ No compelling case for, and the mechanism mismatches your phenotype. The 2024 ADA position is explicit: insufficient evidence to support routine chromium use to improve glycemia in people with diabetes. Meta-analyses do show modest effects (HbA1c ≈ −0.55 to −0.60%) but with mixed study quality — and every trial population is type 2, an insulin-resistance disease. Chromium's proposed action is insulin sensitisation. T3c is insulin deficiency from lost beta-cell mass — sensitisation is not the lever. Effects are also largest in poor baseline control, which is not you. Nothing here argues for reconsidering. |
| NAC · 3,800/day | 🆕 ✅ RAMP COMPLETE ~8/11. Both remaining steps landed together — the 8/14 bolus step moved early, and a 4th daytime capsule was added the same day. 3,800 mg · 48.4 mg/kg · 69% anchor. |
Curcumin, quercetin, resveratrol stay. Human evidence for clinically meaningful bleeding at these doses is essentially nil; platelets are 411. The governing rule is nothing new enters an uncharacterized window — a different rule, and the one that actually moved SPM and Turkey Tail.
🆕 10/1: resveratrol is out from today ⟨N 10-01⟩ — on the unworthy limb and an interaction leg (resveratrol-cut), not on bleeding. Curcumin and quercetin stay; the reasoning above is unchanged.
🆕 Live: 3,800 mg ⟨N 8-11⟩ — ND 1,000 at noon + 500 (3 PM) + 500 (dinner), all fed — the 12:30 PM capsule folded into Meal 1 on 8/26 ⟨N⟩; daytime total unchanged at 2,000 + NOW 600 × 3 at the 8 PM dessert · 48.4 mg/kg. ⏳ 🆕 From Sat 11/7: NOW 600 at 6:00 AM (fasted) + NOW 600 × 2 at the 8 PM dessert — one of the three moves (open item 143); noon, 3 PM, dinner and the day total are unchanged. Tolerability anchor ~70 mg/kg ≈ 5,495 mg, so the live total sits at 69% of it — and at 106% of the highest arm in the largest randomised GlyNAC trial run GlyNAC trial run (Lizzo 2022, n=114, 3.6 g). Struck: the "1,800 mg threshold," the "+500 per clean 7 days" cadence, the "after the PPI question closes" condition, the "1:1 weight ratio," and the overnight window.
🔴 Two increments now sit above the established level; only one has an indication. Your own scope limit ⟨N 8-3⟩: restoring is covered by the burden rule, exceeding needs its own stated indication. 2,800 → 3,300 has one (daytime stimulant-hour coverage + the grounding effect). 3,300 → 3,800 — the 4th daytime capsule — does not. 🆕 That capsule left the 12:30 PM slot on 8/26 and was folded into Meal 1 ⟨N⟩ — the dose is unchanged, so the missing indication is unchanged too. Moving it did not answer it. 🆕 Overtaken 8/14 and noted 10/24: open item 37 closed on his stated indication — Adderall smoother, mood better ⟨N 8-14⟩ — and found 12:30 PM was a restored slot, not the newest. Not a safety question; a bookkeeping one your rule requires. The 3 PM ND is not dropped. Reasons, both ⟨N⟩: daytime coverage during stimulant hours, and the grounding effect Nate notices and had missed.
Steps — both complete: 8/7 ✅ DONE ~8/3 NOW 600 × 2 (2,700) → 8/14 ✅ DONE ~8/11 NOW × 3 (3,300) → 🆕 + 4th ND 500 @ 12:30 PM, same day (3,800). 🆕 That capsule moved into Meal 1 on 8/26 ⟨N⟩ — three daytime slots now, same 2,000 mg.
🆕 Nothing left to step.
or the tolerability reading becomes unattributable.
🚫 No morning NAC slot ⟨N 8-3⟩ — 🆕 superseded 10/24 by his own decision ⟨N 10-24⟩. Which capsule he handed over: from Sat 11/7 one NOW 600 moves from the 8 PM dessert to 6:00 AM, fasted ⟨N 10-24 · delegated, derived C·10-24⟩ — open item 143. Until 10/24 this read “and this still holds.” 🆕 The 4th daytime capsule is now at Meal 1 (12:00 PM) ⟨N 8-26⟩, inside the eating window and with food. It was at 12:30 PM until 8/26. The 8/3 decision declined a capsule at the fasted morning anchor — different slot, different question. temporary — the 8:30 PM → noon fast is being restored — and the AM need isn't noticed the way the rest of the day is. The gap stays a gap. 🆕 Until 11/7 — open item 143.
🔴 🆕 Rule 1 was not satisfied on 8/11. The NAC step, the 4th capsule and Turkey Tail all landed the same day, and all three are read on the identical signal: nausea / epigastric discomfort / bloating / reflux — not stool colour, which Turkey Tail voids from ~8/11. A symptom in the next 3–5 days is unattributable by construction — nothing needs undoing, but no later rev should record it as attributable. 🆕 At 3 caps: Se 75 µg · Mo 150 µg, and from nowhere else. 🆕 From 11/7, 25 · 50 µg of it at 6:00 AM (open item 143).
Decision made 8/15; execution deliberately deferred. Not a safety hold — 11 tests overlap the two orders and form a paired series, and subtracting a compound 6 days out breaks it. Sequencing, not doubt.
🆕 Why it goes on 10/1 — day 0 of the buspirone 15 mg step ⟨C·9-30, adopted 10/1⟩. Resveratrol slows how fast buspirone is cleared: at 1 g/day for 4 weeks, buspirone AUC rose 33% (Chow 2010). Clearance recovers over days to ~2 weeks after stopping, and the step’s read takes 2–4 weeks — cut on day 0, that recovery lands before the judgment rather than across it; cut at ~10/7, buspirone levels would have fallen mid-read. Untested at 250 mg; likely smaller there. Re-checked 9/30: “SIRT1 falsified” overstated it — Hubbard 2013 makes it contested, and in vitro either way; the verdict stands on the null T2D endpoints, the exposure gap and the interaction leg.
Grounds are the unworthy limb of burden-of-proof, not an override of it: the SIRT1 mechanism is falsified (activation appears only with a covalently attached fluorophore), the T2D meta-analyses are null across FBG, HbA1c, insulin, HOMA-IR and lipids, and the one phenotype-matched mechanism — pancreatic stellate cell anti-fibrosis at 12.5–200 µM — misses achievable plasma exposure by 40–600×.
⚠ Three riders leave with the capsule: quercetin −150 · fisetin −10 · grape + wild blueberry −85. 🔴 That grape is grape FRUIT, not the grape SEED cut 8/11 — grapeseed-cut is unaffected. ⚠ Fisetin intake goes to zero, and a never-started senolytic burst protocol remains live intent — no dose or date is on file by design.
The capsule — Life Extension Decaffeinated Mega Green Tea Extract per his 6/4 brand list, ≈326 mg EGCG and ≤3.6 mg caffeine (maker’s spec ⟨?⟩) — had sat at the 8:00 PM dessert since 8/26 and was due back at Meal 1 when iron exited. It returns nowhere. A search for a reason to keep it found none that holds for him: pancreatic work runs at 5–25 µM against ~0.3–0.5 µM reachable; MIRACLE, at this dose, missed its primary endpoint (underpowered); HbA1c −0.18% in T2D and obesity. Against it: −27% non-heme iron absorption at 300 mg in low-iron women, when food is now his only new iron. The liver did not decide it. egcg-cut; open items 77–79 close.
☕ Catechins, if wanted, come from the 9:00 AM green tea — fasted, 3 h from Meal 1, no Creon and no iron-rich food in the way. 🆕 rev 7.81: the daily green tea is at 8:00 AM, cold-brewed ⟨N 10-01⟩ — 4 h from Meal 1. 🆕 rev 7.82: the tea exited 10/10 ⟨N 10-10⟩ — no EGCG in any form.
7:00 AM fasted + 3:00 PM with Meal 2. 7.5 mg × 2 from 9/17 — never recorded until 10/1; the file said “requested, not prescribed.” The milligrams and the equal doses are the prescriber’s; she left the split to him, and he kept 15 + 15 on the same clock ⟨N 10-01⟩. Anxiolysis builds over 2–4 weeks, so this is the window-occupier from 10/1 to ~10/29 — offered: nothing else deliberate lands inside it unless a clinician directs it or a stop-rule trigger fires (open items 101, 126, 127). 🆕 rev 7.81: the 8:00 AM green tea ⟨N 10-01⟩ starts inside this offered window; if it is adopted, the tea is its one named exception ⟨C·10-01, offered⟩ — daily from the step’s start, it sits in the read’s baseline. 🆕 rev 7.82: the tea exited 10/10 ⟨N 10-10⟩. The gabapentin taper started inside this window on 10/7 ⟨N 10-07⟩ — its withdrawal signs overlap the read; log each step’s date. After the read, a step-down of the anxiety-adjacent stack is offered — open item 138.
🛑 Stop rule: any diastolic <55, an orthostatic drop >20/10, or dizziness that does not settle within 2 weeks → stop stepping and tell the prescriber. 🔁 Switch rule ⟨C·9-30, offered⟩: dizziness or blurred vision new or worse than on 7.5 × 2, in the ~2 h after the 3:00 PM dose (gabapentin at 4:00 PM lists both) → 20 mg AM / 10 mg PM, only if the tablets can make those doses (not 7.5 mg tablets). Open items 9 and 136.
🆕 Out 10/10 ⟨N 10-10⟩: no green tea; black coffee at 9:00, the 1:45 PM coffee some days. 🆕 10/29: the coffee and its theanine are at 8:30 — 9:00 on a sleep-in morning ⟨N 10-29⟩. On 10/2 its caffeine was more than he wanted and possibly hard on his digestion ⟨N 10-02⟩, and no green-tea form showed a benefit that reaches him ⟨C·10-02⟩. The rest of this card is the 10/1 record.
Fasted, 4 h before Meal 1 — no iron, Creon or DAO overlap. The 7:30 theanine peaks against its caffeine; buspirone is near its peak; a telmisartan effect via liver OATP1B3 is unlikely and unquantified — the BP readings are the monitor; both BP readings sit outside the acute window. On tea days the 9:00 coffee is a regular cup ⟨C·10-01, adopted 10-01⟩ — as a ceiling, ≤ ~95 mg (offered) — that keeps the 9:45 AM theanine : caffeine pairing in band.
⏳ Named, not gating ⟨C·10-01, offered⟩: the buspirone step’s read (if logging it, note skipped days; if mornings turn edgy, skip the tea first) · the PPI-stop read to ~10/11 · iron mornings if oral iron returns (tea at 9:00 or skipped) · draw mornings (tea after the needle). Not temporary — no reversal block, and it rides no other trigger. Recipe and the usual 9:00 coffee ⟨?⟩ — open item 137.
From his existing fill, keeping the rest in reserve ⟨N 10-01⟩. Plan offered 10/1 ⟨C·10-01, offered⟩: 600 + 600 → 300 + 600 → 300 + 300 → 300 at 8:45 PM only → off — the evening dose goes last, and the 8:45-only step is held longest. As run: straight to 300 + 300 on 10/7, back to 300 + 600 by 10/10 (the reason is not on file ⟨?⟩). The next step and its timing are his; the exit is the prescriber’s call — an FYI is drafted in follow-ups A9.
🔁 Rules ⟨C·10-01, restated 10-07, offered⟩: anxiety, poor sleep or sweating within ~48 h of a step, or the evening RLS urge returning → back up one step and hold. Half-tablets not used within 28 days are discarded (label). The magnesium stays at dinner until the last dose; RESTORE ON GABAPENTIN EXIT fires then, not before. It runs inside the buspirone read — log each step’s date. gabapentin-taper · open item 132.