# 🧬 Master Regimen · v6.11 / rev 7.8

*Version-date: 2026-07-09 · supersedes v6.10 + rev 7.7*
*Live window: 7/9 → 7/31 · canonical IF returns ~Aug 1*
*Hub: protocol-hub.pages.dev*

#regimen #canonical #health

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## ::✅ What changed 7/9::

- **Telmisartan restarted.** 40 mg through 7/15, then 80 mg from 7/16. It was never discontinued — a perioperative hold nobody reconciled. Both charts still list 80 mg daily.
- **Potassium (K citrate) cut** from all three meals. K was 4.6 unsupplemented, eGFR 112. In a K-replete person a potassium load is natriuretic.
- **Breakfast (8:30 AM) cut.** The 6:30 protein bite is sufficient. Holy Basil Force #2 moved to noon.
- **Synapsa Bacopa BID split restored** — 160 mg at 6:15 AM + 160 mg at Meal 1. *The 6:15 dose is no longer absent; that flag is resolved.*
- **Blood pressure is now a regimen slot**, not a note. 5:55 AM triplicate + 1:30 PM postprandial.
- **Adderall 60 mg, XR-only.** Both IR 5 mg doses held. ⚠️ *Confirm before trusting this line.*
- **Truvaga Plus deferred to mid-August** from 7/28.

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## ::⏱ Daily architecture — rev 7.8::

*Markers:* 🫀 blood pressure · 🔵 queued, not started · 🍄 mushroom line · ⏸ held · ⚠️ watch · 🚫 removed

### 🫀 5:55 AM · BP — first action of the day

- Blood pressure — **3 readings, one minute apart**
- **Discard #1. Average #2 and #3.** That is the number.
- Sit 5 min · feet flat, back supported, no talking
- Bare arm, cuff at heart level
- Log to Apple Health — ⚠️ *never the iHealth PDF export (it drops 21 of 39 readings, and drops them low)*

### ☀️ 6:00 AM · fasted

- Omeprazole 40 mg DR — #1 of 2 *(course ends ~7/14)*
- Infini-B (methylated B-complex — active B6/P5P, the DAO cofactor)
- NR 300 mg
- Agmatine 250 mg
- ALCAR 1 g (2 × 500)
- Holy Basil #1 of 3 — NOW, powdered (fine fasted)
- 🔵 *R-ALA (OptimALA) — queued ~7/16*
- 🔵 *Erinamax — queued ~7/19*

### 6:15 AM · cognitive

- Magtein 1.5 g
- ✅ **Synapsa Bacopa 160 mg — BID #1 of 2** *(restored 7/9 · 320 mg/day)*
- 🔵 *Panax GS15-4 — queued ~7/26*

### ::6:30 AM · meds + small protein bite::

- Creon 2–3 caps + protein bite
- ✅ **Telmisartan 40 mg** — *restarted 7/9 · steps to 80 mg on 7/16*
- Adderall XR-1 30 mg (fed)
- ⏸ *Adderall IR (AM) 5 mg — HELD · daily total 60 mg, XR only*
- Cognizin 250 mg
- 🍄 *Lion's Mane — restart ~7/19 (step 1 of ladder)*
- 🍄 *Cordyceps — restart ~8/5 (step 3, half-dose, alone)*

*The protein bite now carries the whole morning: Creon substrate, the fed-state anchor for XR-1, and the fat-free window telmisartan wants. It replaces breakfast.*

### 🍵 7:00 AM · green tea / maté · fasted

- Sodium Chloride 1 g Rx (~390 mg Na) — #1 of 4
- ⚠️ **L-Citrulline DL-Malate 3 g** (2 g citrulline) — *now ADDITIVE with telmisartan. NO-mediated vasodilation stacks on RAS blockade. The 1:30 PM reading is the watch.*
- L-Glutamine 5 g
- Taurine 750 mg
- L-Theanine 100 mg

### 8:00 AM

- PEG 3350 (MiraLAX) 17 g — optional
- Lemon Balm 300 mg (PRN)
- 🚫 *Breakfast (8:30 AM) — **CUT 7/9**. Albumin already recovered 3.0 → 4.0. Holy Basil Force #2 moved to noon, where the EVOO base has fat to ride on.*

### 10:00 AM · mid-morning · fasted

- Myo-Inositol 1 g
- ALCAR 500 mg
- Agmatine 250 mg
- TAU 40 mg *(≠ Taurine)*
- 🔵 *Bilberry — queued ~7/21*
- 🍄 *Cordyceps #2 — restart ~8/5*

### 11:15 AM · mid-morning fasted

- Mastic Gum 500 mg

### 11:45 AM

- Adderall XR-2 30 mg
- NaturDAO 1 tab (pre-meal)

### ::🍽 12:00 PM · Meal 1 — biggest, front-load protein::

**🥑 Fat-anchored — with the first fatty bites**

- Creon 1 + 2 caps
- Sodium Chloride — #2 of 4
- 🚫 *Potassium (K citrate) — **REMOVED 7/9***
- Digestive Enzymes Ultra 1 cap
- Omega-3 (Ultimate Omega)
- D3 5,000 IU + K2
- Urolithin A 500 mg (fattiest bite)
- HMB (CaHMB) 3 g — *bundles ~+1,000 IU D3 + 360 mg Ca · clear of Zn/Mg*
- Curcumin (Nanocur) 500 mg
- Boswellia 350 mg — *AKBA, needs fat*
- ✅ **Holy Basil Force #2 of 3** — *MOVED from 8:30 breakfast · supercritical CO2 in EVOO*
- Grape Seed
- Astaxanthin 12 mg
- EGCG ≤400 mg — ⚠️ *with food, never fasted*
- Ubiquinol 100 mg
- SerinAid PS 200 mg — *soy-lecithin, Creon-safe (lipid fraction, no trypsin inhibitors)*
- Milk Thistle 1 softgel

**💧 Water-soluble — once you've eaten**

- Amino-9 Essentials 1 serving (2¼ tsp) — pulse #1
- 🔵 *ProBiota HistaminX 1 cap — starts ~7/10 · single-variable*
- Glycine 1.5 g
- L-Glutamine 5 g
- PEA 400 mg
- Quercetin Phytosome — *histamine, mast-cell stabilizing*
- OptiMSM 1,500 mg — #1 of 2
- NAC 600 mg (staged) — *1,200/day start → +500 per clean 7-day step → 4,800*
- Taurine 500 mg
- TMG 500 mg
- ✅ **Synapsa Bacopa 160 mg — BID #2 of 2**
- Benfotiamine 300 mg
- PQQ 20 mg
- Ergothioneine 30 mg
- Cognance 100 mg
- Spermidine 3 mg
- Avmacol (sulforaphane) 480 mg
- Myo-Inositol 500 mg
- 🍄 *Turkey Tail 500 mg — restart ~7/28*

### 12:30 PM

- Cognizin 250 mg

### ::🫀 1:30 PM · BP — postprandial · through 7/15 only::

- Blood pressure — **1 seated reading**, 90 minutes after Meal 1
- *This is where pressure falls to 115/50.*
- ⚠️ **Stop rule:** below **100/55**, or lightheaded on standing → **hold at 40 mg. Do not step up on 7/16.**

### 1:45 PM · between

- TAU 40 mg
- L-Theanine 100 mg
- Lemon Balm 300 mg (PRN)

### 2:00 PM

- Agmatine 250 mg
- ALCAR 500 mg

### 2:45 PM · pre-meal

- NaturDAO 1 tab

### ::🍽 3:00 PM · Meal 2 — folded::

- Creon 2–3 caps
- 🚫 *Potassium (K citrate) — **REMOVED 7/9***
- Digestive Enzymes Ultra 1 cap
- Glycine 1 g
- Ester-C 500 mg — *collagen cofactor*
- Longvida (curcumin) 200 mg — *completes the 1,200 mg/day*
- D3 extra 2,000 IU
- Taurine 500 mg
- Myo-Inositol 500 mg
- Avmacol 480 mg
- 🍄 *Lion's Mane #2 — restart ~7/19*

*Stays folded (old 2:30 + 4:30) through 7/31. At the Aug 1 gate this becomes the canonical 3 PM IF meal — same slot, no move.*

### 4:00 PM

- ⏸ *Adderall IR (PM) 5 mg — **HELD**. The late-afternoon pressor is gone, which is part of why the stimulant is not driving BP.*

### 5:00 PM · between

- Sodium Chloride — #3 of 4 *(even-spread, decoupled from meals)*
- Taurine 500 mg
- ALCAR 500 mg
- Agmatine 250 mg

### 6:00 PM · pre-dinner

- Omeprazole 40 mg DR — #2 of 2 *(nocturnal coverage · course ends ~7/14, plan past that is open)*
- Mastic Gum 500 mg

### 6:15 PM · pre-dinner

- L-Theanine 200 mg
- Berberine Phytosome 275 mg — #1 of 2 · *~5× bioavailable · 7-day CGM window before R-ALA*

### 6:25 PM

- NaturDAO 1 tab

### ::🍽 6:30 PM · Dinner::

**🥑 Fat-anchored**

- Creon 1 + 1 caps
- 🚫 *Potassium (K citrate) — **REMOVED 7/9***
- Digestive Enzymes Ultra 1 cap
- Curcumin (Nanocur) 500 mg
- Boswellia 350 mg
- Grape Seed
- Resveratrol blend — *lipophilic, fat-anchored*
- Vitamin E ≤400 IU — *weak vit-K signal → low-dose cap only, no tocotrienol megadose*
- 🔵 *SPM Pro-Resolve 1 softgel — starts ~7/11*
- Zinc / Copper 15 / 1 mg — *anastomotic healing*
- Ubiquinol 100 mg
- SerinAid PS 100 mg
- Holy Basil Force #3 of 3 — *EVOO base, meal-anchored*

**💧 Water-soluble**

- Amino-9 Essentials 1 serving — pulse #2 *(well-separated from Meal 1)*
- 🔵 *MegaSporeBiotic 1 cap — starts ~7/13 · only after ProBiota tolerance*
- Glycine 1.5 g
- L-Glutamine 5 g
- PEA 400 mg
- Urolithin A 500 mg
- OptiMSM 1,500 mg — #2 of 2
- NAC 600 mg (staged) — pulse #2 of the 1,200/day start
- TMG 500 mg
- 🍄 *Turkey Tail 500 mg — restart ~7/28*

### 7:00 PM

- Taurine 300 mg
- Magtein 1 g — #2

### 7:45 PM · pre-dessert

- Gymnema 400 mg — *glucose-active, with the carb load*
- Berberine 275 mg — #2 of 2

### ::🍽 8:00 PM · Dessert — light::

- Creon 1 cap
- Digestive Enzymes Ultra 1 cap
- Milk Thistle 1 softgel

### 8:45 PM · wind-down

- Sodium Chloride — #4 of 4 *(later coverage blunts the overnight Na drop)*
- Taurine 1 g
- L-Theanine 200 mg
- Myo-Inositol 500 mg
- Mg Bisglycinate 200 mg (ND)

### 🌙 9:30 PM · melatonin

- Melatonin 3 mg — *~30 min before sleep*

### 9:45 PM · pre-sleep — last action

- Glycine 3 g — *GlyNAC overnight, glycine half*
- Apigenin 100 mg — *histamine, complements quercetin*
- Lemon Balm 300 mg
- ⚠️ *NAC overnight bolus (1,800 mg + Selenium 75 mcg) is **NOT here yet**. It is the **last** step of the ramp — it lands only after the daytime escalation is tolerated.*

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## ::💊 Rx::

- **Telmisartan** — 40 mg → 80 mg on 7/16 · 6:30 AM. *ARB + partial PPAR-γ agonist; the PPAR-γ effect is dose-dependent, and 80 mg is where the T3c insulin-sensitizing benefit lives.*
- **Adderall XR** — 30 mg × 2 · 6:30 AM + 11:45 AM · fed. **60 mg/day.**
- ⏸ **Adderall IR** — 5 mg × 2 · HELD
- **Creon DR** — 2–3 caps, every eating occasion. *Essential, non-negotiable.*
- **Omeprazole DR** — 40 mg × 2 · 6:00 AM + 6:00 PM. *Course ends ~7/14; rebound hypersecretion peaks in the two weeks after stopping.*
- **Sodium Chloride** — 1 g × 4 · ~1,560 mg Na/day. *Na reached 134 — hold steady, don't ease off.*
- **PEG 3350** — 17 g · 8:00 AM · optional

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## ::🫀 Blood pressure — the numbers::

**Baseline · 39 readings · Jul 4–8 · Apple Health**

- All readings, raw mean — **136.8 / 67.8**
- Session means, first discarded — **135 / 67**
- Fasted, pre-dose — **138 / 68**
- Jul 5, 9:16 AM (5 consecutive) — **149 / 74**
- Postprandial — **115–128 / 50–62**
- Pulse pressure, fasted — **~68 mmHg**

**Two blood pressures, not one.** A >35 mmHg postprandial fall. In Type 3c that points at autonomic involvement. *The low readings were meals. They were never the drug working.*

**Stop rules**

- Any postprandial reading **below 100/55** → hold at 40 mg, don't step up 7/16
- **Lightheaded on standing** → hold at 40 mg, message Kuhlman
- Any reading **≥180/120** → urgent care. Not a message, not a wait.
- Morning average still **≥130 after two weeks at 80 mg** → escalate

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## ::📅 Cascade ahead::

- **~7/10** — 🔵 ProBiota HistaminX *(Meal 1 · gate opened by stent removal · single-variable)*
- **~7/11** — 🔵 SPM Pro-Resolve *(Dinner, fat-anchored)*
- **~7/13** — 🔵 MegaSporeBiotic *(Dinner · only after ProBiota tolerance)*
- **7/16** — ✅ **Telmisartan → 80 mg** *(unless a stop rule fired)*
- **~7/16** — 🔵 R-ALA (OptimALA) *(after the Berberine CGM window)*
- **~7/19** — 🍄 Lion's Mane / Erinamax *(gastroprotective; a healing duodenum argues FOR it)*
- **~7/21** — 🔵 Bilberry *(own CGM window)*
- **~7/26** — 🔵 Panax GS15-4 *(own CGM window)*
- **~7/28** — 🍄 Turkey Tail *(prebiotic — waits for probiotic attribution)*
- **~8/1** — 🚦 **IF gate** *(Wancata check-in + draw → canonical 12–8 window)*
- **~8/5** — 🍄 Cordyceps *(antiplatelet-adjacent AND CGM-active. Goes last, alone, half-dose.)*
- **~mid-Aug** — 🔵 **Truvaga Plus** *(moved from 7/28 · morning fasted, never postprandial · one 2-min bilateral session)*

**NAC ramp runs alongside:** 1,200/day → +500 per clean 7-day step → 4,800. Overnight bolus lands last. Every addition stays ≥72 h from a NAC step — *and the 7/16 telmisartan step counts as an addition.*

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## ::📊 Key daily totals::

Taurine 3,550 · TAU 80 · Glycine 7,000 · **NAC 1,200 → ramping to 4,800** · ALCAR 2,250 · Myo-Inositol 2,500 · L-Theanine 600 · L-Glutamine 15 g · NR 300 · Agmatine 1,000 · **Synapsa Bacopa 320** · Curcumin 1,200 (Nanocur 1 g + Longvida 200) · **OptiMSM 3,000 (2 slots)** · Mg elemental ~380–440 · Vit D3 ~8,000 IU *(incl. HMB bundle)* · PEA 800 · Urolithin A 1,000 · Boswellia 700 · Berberine 550 · Citicoline 500 · Spermidine 3 · Melatonin 3 · Sodium ~1,560 mg · **Potassium supplement: none**

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## ::🔍 Open — clinical facts to obtain::

1. **UACR** (urine albumin:creatinine) on the ~Aug 1 draw. *Microalbuminuria → RAS blockade indicated regardless of the cuff.*
2. **Orthostatic vitals** — supine, then 1 and 3 minutes standing. *Tests the postprandial fall.*
3. **24-hour ABPM.** *Settles the dose question in a day instead of two weeks.*
4. **Med reconciliation.** *Both VM and Providence still list telmisartan 80 mg daily. You were on zero, at 149/74 fasted. Document the hold and the 7/9 restart.*
5. **Ferritin + iron saturation.** *Not drawn 7/7. Decides iron repletion vs. let-it-rebuild — and iron is mucosally irritating into a healing duodenum.*
6. **PPI plan past 7/14.** *Sets the ulcer runway and the acid environment the probiotics land in.*

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## ::🚫 Standing constraints::

- ❌ **Acetaminophen** — documented adverse (Virginia Mason, July 2026)
- ❌ **NSAIDs** — contraindicated (ulcer / GI-bleed history)
- ❌ **Soy** — enzyme-function issue, stops Creon working. *(SerinAid PS is the exception: soy-lecithin lipid fraction, no trypsin inhibitors.)*
- ❌ **Potassium supplements** — as of 7/9
- ⚠️ **Clinical interpreter note:** the supplement regimen produces atypically suppressed inflammatory markers (WBC, CRP). *Clinical suspicion should outweigh standard lab thresholds when assessing acute infection, cholangitis, or pancreatitis flare.*

### 📞 Call the team — not a supplement question

Dark or tarry stool · visible blood · new dizziness · resting HR climbing · fever or rigors · any BP reading ≥180/120

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*Master Regimen v6.11 · rev 7.8 · 2026-07-09*
*Supersedes v6.10 and rev 7.7 — the latter was built on a filtered BP export.*