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rev 7.86 · built 10/29

Daily architecture

One supplement per row. The dot on the spine is now.

Names and doses only. Every annotation is hidden, not removed — this is the same markup as Full view, so the two cannot disagree. Oral iron has exited — IV iron was given 9/23. 🆕 10/1: resveratrol and EGCG have exited; buspirone is 15 mg at 7:00 AM and 3:00 PM. 🆕 10/10: spermidine, the 8:00 AM green tea and the PRN reflux rescue are out; the 9:00 drink is black coffee; gabapentin is tapering — 300 mg at 4:00 PM, 600 mg at 8:45 PM. 🆕 10/15: twelve products were queued to change at their next bottle — ⏳ marks each line still waiting; until that bottle is in hand, take the current one. 🆕 10/23: the digestive enzymes go live from dinner — Digest Basic, 1 per meal; its watch runs 10/24–11/6. 🆕 10/24: from Sat 11/7 one NAC capsule moves from 8 PM to 6:00 AM — ⏳ marks both lines. 🆕 10/29: the morning coffee and its 200 mg theanine move to 8:30 — 9:00 on a sleep-in morning; L-glutamine stays at 15 g a day, and at noon and dinner it goes with the first bites. TAU is Triacetyluridine, not taurine.

Soy — activity-gated, not categorical

Kunitz and Bowman-Birk inhibit trypsin and chymotrypsin only — not lipase, and Creon is dosed in lipase units and titrated on fat absorption. The only surviving concern is CCK / protease-feedback at raw-flour scale. Yardstick — 🔴 NOW HISTORICAL, NOT LIVE ⟨C·8-15⟩: NaturDAO ~96 mg/day legume protein was cleared (32.1 mg × 3 tablets). That product left the regimen 8/15 and its porcine replacement carries ZERO legume protein. The number survives as the highest legume exposure this regimen has cleared in practice, but it is no longer a live intake and must not be cited as one — measure candidates against it as history, not as label presence. ⟨? | a — unsourced in every rev; not on the Creon FDA label⟩

5:55 AM
Blood pressure first action
  • 3 readings, one minute apart
  • Discard #1. Average #2 and #3. That is the number.
  • Sit 5 min · feet flat, back supported, no talking
  • Bare arm, cuff at heart level
  • Log to Apple Health
6:00 AM
Fasted
  • Infini-B — methylated B-complex 25 mg P5P = 16 mg B6🔴 DAO-“cofactor” rationale STRUCK 7/22. DAO is a copper amine oxidase (Cu · Ca · TPQ). PLP is the cofactor for histidine decarboxylase — histamine synthesis. B6 is not a DAO lever. Standalone P5P 50 mg rejected (would be 49 mg B6 ≈ 4× EFSA UL).
  • NR 300 mg⏳ next bottle → Life Extension NAD+ Cell Regenerator (Niagen)
  • ALCAR 1 g (2 × 500)
  • 🆕 Holy Basil #1 of 3 — NOW, capsule (fine fasted)🔴 RESTORED to 6:00 AM ⟨N✲4 9-04⟩ — the 9/3 relocation is reversed. Rosmarinic acid is a genuine catechol iron-binder, but this is 1/3 of a capsule, never quantified in any rev, and a PPI is running. Capsule-scale polyphenol against a drug-level inhibitor.
  • 🆕 Panax Ginseng GS15-4 200 mg🔴 RESTORED to 6:00 AM ⟨N✲4 9-04⟩ — ND, 1 cap. Dose unchanged, total Δ = 0. rev 7.63 classed this as a "polyphenol-bearing capsule" and that was a category error: GS15-4 is a ginsenoside-standardised extract and ginseng’s principal actives are triterpene dammarane saponins, which lack the galloyl/catechol groups Hurrell’s inhibition runs on. See ginseng-polyphenol-class.
  • 🆕 R-Lipoic Acid (Na-R-ALA) 300 mg🔴 RESTORED to 6:00 AM ⟨N✲4 9-04⟩ — the falsified one. The paper rev 7.63 cited is "α-lipoic acid attenuates duodenal non-heme iron absorption via microRNA-mediated regulation of DMT1 in iron overloaded rats" ⟨Mol Biol Rep 2025⟩. ALA cut DMT1 protein without changing mRNA — post-transcriptional control of transporter density, not luminal chelation. A systemic change in transporter number cannot be defeated by a two-hour gap. See ala-iron-chelation.
  • 🆕 NAC 600 mg — NOW w/ Se and Mo, 1 cap⏳ from Sat 11/7 — not yet🆕 Moves here from the 8 PM dessert ⟨N 10-24 · delegated, derived C·10-24⟩, for NAC coverage in the morning Adderall hours ⟨N 10-24⟩. A full glass of water, upright, 30 min ahead of the 6:30 Adderall. Starts after the enzyme watch, once the clean mornings hold and buspirone has settled; on a homocysteine-draw morning, after the draw. Days 1–5, any nausea, upper-stomach burning, heartburn or bloating sends it back to 8 PM. Day total unchanged at 3,800. Item 143.
  • 🧍 🆕 Take the morning bundles upright ⟨N 10-09⟩His 10/9 practice — sitting or standing, and no pain. Offered with it ⟨C·10-09, offered⟩: a full glass of water across each bundle, and upright ~30 min before lying back — capsules swallowed reclined can sit in the esophagus and burn like acid.
  • ⏹ 🩸 IRON — EXITED 9/23 ⟨N 9-23⟩ · INFeD 1,000 mg, one total-dose infusion · trigger (b) fired🆕 Oral iron has exited entirely; no premeds were given. Re-entry is a new decision, not a restore: the recheck is readable no earlier than ~4 weeks (~10/21) — a request to Kuhlman, not an order 🆕 ORDERED at Labcorp ⟨N 10-01⟩ (item 130 — the re-entry rules are written there). 🆕 9/30: at the 9/22 Hgb of 12.0 the 1,000 mg covers 114% of the re-derived deficit; GGT · PTH · zinc · DXA were added to the request — it reached Kuhlman ⟨N 10-01⟩; which made the order ⟨?⟩. Both 9/21 offers were accepted ⟨N 9-23⟩: the 9:00 AM drink stays, and EGCG waited for the ~10/1 read — 🆕 then EXITED 10/1 ⟨N 10-01⟩ (items 62, 79, 128). ⚠ 9/24–~9/29: the delayed-reaction window — no acetaminophen or NSAIDs; fever, chills or back pain are not self-attributable to the iron (item 131). 🆕 Ended ~9/29. What follows is the record.🆕 HELD ⟨N 9-21⟩, NOT CUT. The base stays 36 mg · 2 caps · alternate days. Trigger (b) retires oral iron when the infusion course completes (one total-dose infusion: 9/23; a series: its last dose); if the infusion falls through, resume on the next alternate day. Re-entry afterwards is a recheck decision, not before 5 days after the last dose (EU iron-dextran leaflet). 🔴 Reconciled with the file, offered: on (b) the 9:00 AM drink stays — the 9/10 theanine pairing now holds it (item 62) — and EGCG waits for the ~10/1 Adderall read (item 79). ⚠ Infusion day: delayed aches and fever are common, and the usual answer — acetaminophen or an NSAID — is a hard constraint; say so at check-in.🆕 BACK TO 36 mg, ALL OF IT HERE, FROM 9/17 ⟨N 9-17⟩ — reversal trigger (a) fired on a dose-graded, iron-day-only intolerance; the 7:30 half has ended. History: 36 → 72 mg ⟨N✓9-03⟩, split 2 + 2 from 9/15 ⟨N 9-15⟩. NOW Foods Ferrochel® (Albion) — 18 mg elemental/cap from 90 mg ferrous bisglycinate; the label does the conversion, so record 18, never 90. 120 caps = 60 doses ≈ 4 months at 2 caps (30 doses ≈ 2 months at 4, 9/03–9/17). Why 2 caps: an n=480 RCT found 18 mg bisglycinate no different from placebo on ferritin at 12 weeks (vs 60 mg ferrous sulfate) — in iron-replete women, so it does not transfer cleanly here, but it establishes 18 mg as a maintenance dose. The dose with trial support is 25 mg; 36 clears it. Alternate-day because hepcidin stays up ~24 h after a dose. 🛑 SKIP THE DOSE FOR 48 h BEFORE THE KUHLMAN DRAW — 🆕 scheduled 9/22 ⟨N 9-21⟩; the 9/21 dose is the one it skips (this line carried “~8/21”, which never happened, then “date unset”; corrected 9/15 and 9/21) — iron studies want ≥24 h clear. ⚠ Peanut is not on its allergen-exclusion line — open item 61. THE LEDGER: the 36 mg base is established and protected; the +36 increment (9/03–9/17) has exited. 🆕 WHY 36 WORKS ⟨C·9-17⟩: FORTE — bisglycinate 30 vs 60 mg, alternate vs daily, 56 days — met its primary endpoint (ferritin <15) at every iron dose, in non-anemic donors; Moretti’s “40 mg” arm was a 36 mg capsule plus a 4 mg tracer. What it costs: Moretti’s first-dose fit keeps ~62% of the absorbed iron of 72 mg — about 19 mg/week less, small beside the ~1,272 mg deficit the infusion is for. 🔄 Reversal: trigger (a) fired 9/17 — capsule count only; trigger (b), IV repletion, retires oral iron entirely and alone moves the iron-exit relocations (open items 62, 79). 🔵 Re-derived 9/17: ~7–12 months at 36 mg before any PPI effect — the 9/15 figure read Moretti’s second-consecutive-day curve. 🟠 36 mg mornings were “a bit off” too ⟨N 9-17⟩ — next levers named in open item 125, not adopted.
6:15 AM
Cognitive · ⚕ 🆕 Telmisartan moved in ⟨N 9-09⟩
  • ⚕ Telmisartan 40 mg — 🆕 MOVED 6:30 → 6:15 AM ⟨N 9-09⟩Execution-driven — it sits in a smaller pill-holder compartment here and can be grabbed on its own on an off-schedule morning. Nothing pharmacological opposed it: telmisartan is not a chelation-sensitive scaffold, its label carries no multivalent-cation interaction, and 15 minutes against a ~24 h half-life is noise. Still fasted.
  • Magtein 667 mg — #1 of 3 · Nootropics Depot, 1 capCapsule ⟨N 9-15⟩ — was “cap or powder”. 667 mg Magtein, 48 mg Mg per capsule (vendor page); in hand and running for months ⟨N✓9-15⟩. 🆕 Indication adopted 9/15 ⟨C·9-15⟩: cognition, weakly.
  • Synapsa Bacopa 320 mg — single AM cap🆕 rev 7.83: this line read 360 mg — a records slip; the capsule is 320 at Nootropics Depot and CGN alike ⟨C·10-13⟩. The dose never moved.⏳ next bottle → CGN Bacopa (Synapsa)
  • ✅ Saffron 30 mg — LIVE ~7/15 ⟨N⟩ND, Crocus sativus stigma extract, 7.5% crocins / 1.0% safranals, 1 cap. A returning member, not a new addition — see saffron-membership.
  • 🔵 Agmatine Sulfate 250 mg — #1 of 4 — starts 8/7 post-draw⚠ Sits 15 min ahead of telmisartan. You ran that pairing for months; the 5:55 AM series is pre-dose so it will not catch it.
6:30 AM
Morning Rx — fasted 🆕 bite cut 8/3
  • 🗑️ Creon + protein bite — CUT 8/3 ⟨N⟩Two hard-boiled eggs, removed with the fasting restart (8:30 PM → noon). No food, no lipase substrate — Creon goes PRN and returns automatically on any transitional snack, per the standing rule. Everything else in this slot is fine fasted.
  • 📜 ⏸ Telmisartan 40 mg — 🆕 moved to 6:15 AM on 9/09 ⟨N 9-09⟩ — one dose, not two🔴 "Fat-free window" rationale STRUCK 7/22. FDA label: food reduces AUC ~6% at 40 mg; Micardis may be given with or without food. The eggs were never a problem, and a fasted slot would raise exposure ~6% during a hold. No move. Records still list 80 mg — correct the stale figure.
  • Adderall XR-1 30 mg — now fastedLabel permits with or without food; a high-fat meal only delays Tmax. Onset slightly faster fasted. Prescribed — tell Murage the timing context changed.
  • Adderall IR-1 5 mg — now fasted — ACTIVE
  • Cognizin 250 mg
  • 🔴 L-Theanine 100 mg — 🆕 HALVED 200 → 100 ⟨C·9-10⟩California Gold, AlphaWave® — 1 cap. Funds the new 9:00 AM dose — 🆕 at 8:30 from 10/29. A 200 mg dose here peaked 7:21 AM against an IR-1 peak at ~9:30 — spent two hours before the stimulant it was paired with arrived. Derivation at the 8:30 AM slot (9:00 until 10/29).
  • 🍄 Lion’s Mane 500 mg — #1 of 2Real Mushrooms — fruiting body, hot-water extract, β-glucans. Fine fasted. The fat-dependence premise (erinacine-lipophilicity) applied to Erinamax — which left the regimen ~9/8 — and never to this product.
  • 🍄 Cordyceps 500 mg — #1 of 2 · STARTED 8/24 ⟨N✓8-24⟩Real Mushrooms CORDYCEPS-M — organic Cordyceps militaris extract, 1,000 mg per 2-cap serving → 500 mg/cap → 1,000 mg/day, 12.7 mg/kg, β-(1,3)(1,6)-glucans 80 mg = 8%. 🔴 Species matters: Cs-4 (C. sinensis mycelium) carries almost all the human evidence; militaris carries the cordycepin and a much thinner trial base. 1,000 mg is the FLOOR of the studied 1,000–3,000 mg range. Cordycepin content not on the label — ⟨?⟩. Open item 74. ✅ Open item 69 CLOSED on a bottle read. 📌 The VM chart's cordyceps 1,000 was right — notable, since three other entries on that chart were stale. ⚠️ Three written restart conditions were not met: not last, not alone (four changes share 8/24), and not half-dose — half is 1 cap/day. Open item 70.
7:00 AM
Fasted · 🩸 tea moved out 8/17
  • ⚕ Buspirone 15 mg — 1 of 2 · fasted🆕 LIVE SINCE 9/17 ⟨N 10-01⟩ — 7.5 mg here and at 3:00 PM from 9/17, 15 + 15 from 10/1; recorded 10/1 (the file said “requested, not prescribed”). Tablet strength and prescriber ⟨?⟩ — item 136. Stop rule: any diastolic <55, an orthostatic drop >20/10, or dizziness that does not settle within 2 weeks → the prescriber sets the level. 🆕 🚨 Same-day care for agitation, tremor or muscle jerks, heavy sweating, shivering or confusion — serotonin syndrome is rare, but Adderall’s label names buspirone ⟨C·10-08, offered⟩. Grapefruit is the one food to avoid (buspirone AUC 9.2× in the label).
  • Sodium Chloride 1 g Rx (~390 mg Na) — #1 of 4
  • L-Glutamine 5 g🆕 Kept at 15 g a day ⟨N 10-29⟩ — re-derived ⟨C·10-29⟩: the two trials that exist used exactly 15 g/day; raised gut permeability has been measured in chronic pancreatitis (group data, not a measurement of him); nothing supports 5 g/day. Safety is calibrated, not cleared — VKM asks for safety studies in diabetics (T3c), and the 9/22 ALP is an open flag. On a sleep-in morning this dose goes in near 8:00, so the cup waits until 9:00. If the label allows room temperature, a jar upstairs saves the trip (offered); mix just before drinking.
  • 🧂 Iodine 150 µg — NaturesPlus, potassium iodide, 1 tablet ⟨N 9-09⟩ 🆕 ✅ LIVE ~9/4🔴 STARTED ~9/4 AHEAD OF THE DRAW ⟨N 9-11⟩ — so the panel it was gated for is now an on-iodine one. It carries the first thyroid panel on record. Contributes 46 µg potassium, four orders of magnitude below the ARB constraint.
  • Taurine 750 mg powder · or 1,000 mg cap (2 × 500)🆕 Cap form raised to 1,000 ⟨N 8-10⟩. No meal to anchor to inside the fast, so this slot serves the Adderall XR-1 / IR-1 onset only.
  • 🩸 Green tea / maté has LEFT this slot → 9:00 AM ⟨N 8-17, moved again 8-26⟩Tea polyphenols are among the strongest inhibitors of non-heme iron absorption, and 1 h behind the 6:00 AM iron dose is not enough separation. The drink moved; no dose changed and no total moved. ⚠ This reverts on IRON's exit, not gabapentin's — two temporary changes now run on different triggers. Open item 62. 🆕 9/21, offered ⟨C·9-21⟩: on trigger (b) the drink stays at 9:00 — the 9/10 theanine pairing now holds it. 🆕 Accepted 9/23 ⟨N 9-23⟩ — iron exited and the drink stayed at 9:00. 🆕 The 8:00 AM green tea added at rev 7.81 is a separate daily drink — 🆕 it exited 10/10 ⟨N 10-10⟩. 🆕 10/29: the morning coffee and its theanine move to 8:30 ⟨N 10-29⟩.
7:30 AM
Fasted
  • 🔴 THREE ITEMS HAVE LEFT THIS SLOT → BACK TO 6:00 AM ⟨N✓9-04⟩Holy Basil #1, Panax GS15-4 200 mg, R-Lipoic Acid 300 mg. They were here for one day. No dose changed, all three totals Δ = 0. Derivation and the ⟨C⟩ ruling live at the 6:00 AM slot.
  • L-Theanine 100 mgCalifornia Gold, AlphaWave® — 1 cap. Covers the XR-1 first pulse (~2–3 h post-dose). Plasma t½ ~1 h, so it does not stack with the 6:30 dose. It also pairs with the 8:00 AM green tea — peaks ~8:20 against the tea’s ~8:30–9:00 caffeine ⟨C·10-01⟩. 🆕 Moot: the tea exited 10/10 ⟨N 10-10⟩.
  • Lemon Balm 300 mg (PRN)Vitacost — Cyracos® ⟨N 8-11⟩. 🆕 Hold lifted 9/17 ⟨N 9-17⟩ — the iron half that shared this slot has ended; it was held on iron mornings 9/15–9/17.
  • 🔴 THE SECOND IRON HALF HAS LEFT THIS SLOT → BACK TO 6:00 AM ⟨N 9-17⟩It sat here 9/15–9/17. The whole alternate-day dose is at 6:00 AM again — reversal trigger (a). Derivation and scope: master-regimen.md, 6:00 AM slot.
  • ⏸ 8:00 AM drug-peak BP slot — suspendedReinstate with any telmisartan change. 🆕 A telmisartan step would move the dose to the evening, taking this reading off 8:00. If reinstated, read first, then the 8:00 green tea — the tea exited 10/10 ⟨N 10-10⟩.
8:30 AM
L-Theanine + optional drink 🆕 sleep-in: 9:00
  • 🔴 L-Theanine 200 mg — 🆕 NEW DOSE AT THIS SLOT ⟨C·9-10⟩🆕 MOVED 9:00 → 8:30 ⟨N 10-29⟩, with the cup — 9:00’s iron reason ended 9/23, and the pairing travels. On a sleep-in morning, 9:00.Nootropics Depot — 1 cap. NOT optional — only the drink is. Funded by halving 6:30 AM and striking 10:00 AM: day total unchanged at 1,500, dose count unchanged at 10, capsule use unchanged (5 ND + 5 CGN). Why: the 7:30 → 10:00 gap was 2h30, the largest daytime theanine interval, and it held both the coffee and the ~9:30 AM IR-1 peak. PK (van der Pijl 2010: lag ~10 min, absorption t½ ~15 min, elimination t½ ~65 min, Tmax ~50 min): day floor 53.8 → 73.9, peak:trough 4.28 → 3.11, 9:45 AM 70 → 179 🆕 (9/10 figures, computed for a 9:00 dose). Afternoon numerically untouched — 1:30 PM 153 → 152, 4:30 PM 174 → 174. Why 200 not 100: the drink is a full coffee ⟨N✓9-10⟩; trial ratios run 1.25:1–2.4:1 theanine:caffeine, so 200 lands inside the band at any cup size and 100 falls below every trial. Fasted slot — no LAT1 competition. ⚠ Peanut named by neither product label: unverified gap, not a known exposure.
  • ☕ Coffee — black ⟨N 10-10⟩ — OPTIONAL ⟨N 8-26⟩🆕 At 8:30 from 10/29 ⟨N 10-29⟩ — 9:00 on a sleep-in morning, when the condensed start puts the 7:00 glutamine near 8:00 (glutamine may compete with theanine for an absorption carrier — animal data only). 🆕 Black coffee (at 9:00 until 10/29) and, some days, the 1:45 PM coffee; no green tea ⟨N 10-10⟩ — the green tea / maté alternative comes off the line with it. The 200 mg theanine above was sized for a full coffee alone (2.11 : 1 at 95 mg · 1.33 : 1 at 150 mg), so it stands; the regular-cup rule rode on the 8:00 tea and ends with it. Cup size not stated ⟨?⟩.📜 Was: green tea or maté — OR — coffee (caffeinated), optional ⟨N 8-26⟩ · after the 8:00 tea: regular-size (≤ ~95 mg) ⟨C·10-01⟩.🩸 Moved 8:00 → 9:00 AM ⟨N 8-26⟩; separation from the 6:00 AM iron dose goes 2 h → 3 h. L-Theanine and the PRN Lemon Balm stay at 8:00 (at 7:30 since 9/09 ⟨N✓9-09⟩ — the 8:00 slot held the green tea 10/1–10/10) — only the beverage moved.
    ✅ Coffee here is neutral-to-favourable vs tea on iron, which is the opposite of what was assumed: in the only direct head-to-head, coffee cut non-heme iron absorption 39% against tea's 64%, and coffee was significantly less inhibitory (ratio 0.59, p<0.001) ⟨Morck, Am J Clin Nutr 1983;37:416–20, PMID 6402915 — results read, methods not opened ⟨?⟩⟩.
    ⚠ Caffeine: 2.5 h after XR-1, ~3 h before the new 11:55 XR-2 🆕 2 h 15 m before the 11:15 XR-2 (moved 9/01). 🆕 At 8:30: 2 h after XR-1 and 2 h 45 m before XR-2. Both BP readings (5:55 AM, 1:30 PM) sit outside the acute caffeine window — neither is contaminated.
    🔴 This line also fixes an HTML gap: rev 7.47 moved the drink to 8:00 AM in the markdown and never added it to any slot here. It has been missing from this page for eight revs.
  • ⏹ 🍵 The 8:00 AM green tea — EXITED 10/10 ⟨N 10-10⟩Added 10/1. On 10/2 its caffeine was more than he wanted and possibly hard on his digestion ⟨N 10-02⟩, and no green-tea form showed a benefit that reaches him ⟨C·10-02⟩. The 8:00 slot is gone; its derivation is in the archive (rev 7.82). Open item 137 closes.
10:00 AM
Mid-morning · fasted
  • Myo-Inositol 1 g — NOW, 2 caps500 mg per cap ⟨N✓9-15⟩. 🆕 Indication written 9/15 ⟨C·9-15⟩: glycemic lead. Sits 60 min behind the 9:00 drink — flagged, not moved (open item 117). 🆕 90 min behind the 8:30 drink from 10/29 — revisited ⟨C·10-29⟩, nothing moves. 🆕 The 8:00 AM green tea that sat 2 h ahead exited 10/10 ⟨N 10-10⟩.⏳ next bottle → NOW powder, 1 g (¼ + ⅛ tsp, or weigh it)
  • ALCAR 500 mg
  • ✅ Bilberry 100 mg — LIVE ⟨N⟩LE MirtoSelect 100 mg fruit, 36% = 36 mg anthocyanins/day — 11–21% of every dose where a human glycemic or antiplatelet effect was shown. Bleeding concern largely defused at this dose; so is the expected glucose effect.
  • 🔵 Agmatine Sulfate 250 mg — #2 of 4 — starts 8/7Clean, uncrowded slot.
  • 🍄 Cordyceps 500 mg — #2 of 2 · STARTED 8/24 ⟨N✓8-24⟩1,000 mg/day total. 🔴 Glucose-active AND antiplatelet-adjacent. The Kuhlman draw (🆕 9/22 ⟨N 9-21⟩) carries fructosamine, insulin and HOMA-IR, so those endpoints will be an ON-CORDYCEPS reading. And he is ~8 weeks off a transfusion-requiring bleed at ferritin 10 with stool colour already voided as a monitor. Substitute monitors carry it: lightheadedness · fatigue · resting HR · the iron panel.
11:15 AM
Mid-morning fasted · stimulant
  • ⏹ ⚕️ Pantoprazole 40 mg DR — STOPPED 9/20 ⟨N 9-21⟩🆕 Ran out 9/20; Wancata had said he’d be fine to stop. Refill held as a backstop, not taken daily. 🆕 PRN rescue — CUT 10/10 ⟨N 10-10⟩. PRN rescue: Gaviscon Double Action 20 mL ~30 min after dinner · famotidine 20 mg for breakthrough (at most 2 in 24 h). Not Gaviscon Advance — 78 mg potassium per 10 mL, ~312 mg/day at four doses — and not US Gaviscon, whose aluminium/magnesium is the gabapentin collision. Resume 40 mg daily here and tell Wancata 🆕 (corrected 10/8 ⟨C·10-08⟩) if the pain gets worse instead of better, wakes him at night, or stops easing when he eats at noon — if it worsens after week 1, needs rescue most days past two weeks, or persists ~10/11: persistence alone is not a trigger, since rebound can run a month or more (Reimer 2009). 10/9: a pain-free morning, no antacid ⟨N 10-09⟩. 🚨 ER, not self-treatment, for tarry stool, vomiting blood, fainting, severe or back-boring pain, fever or yellowing — WBC and CRP can read normal. Full block: master-regimen.md, 11:15 AM.🔴 MOVED 6:00 AM → 11:15 AM ⟨N✓9-03⟩. 🔴 THIS DRUG WAS NOT IN THIS FILE AT ALL, IN ANY REV. "Pantoprazole" appeared zero times in rev 7.61. The only PPI entry was "Omeprazole DR — discontinued, course complete," which is true and is not struck — but a different molecule has been running daily, unrecorded. Both iron sweeps (8/17, 8/26) ran against a schedule missing it.
    Stated by Nate 9/3: 40 mg TBEC once daily, 6:00 AM slot; stopped ~3 weeks mid-August, restarted after discomfort that restarting resolved. Prescriber: Wancata ⟨N✓9-03⟩.
    🔴 Why the clock moved and the dose did not: PPIs bind only actively secreting pumps, and eating activates them. First meal is noon, so a 6:00 AM dose was followed by six hours of fasting. Pre-meal dosing left gastric pH <4 for 17.2% of the day vs 42.0% when no meal followed (p=0.01) ⟨secondary source ⟨?⟩⟩. ⚖ Calibrated both ways: the FDA label says DR tablets may be taken without regard to meals — food delays Tmax ~2 h, Cmax and AUC unchanged. The pharmacodynamic argument carries this, not a PK one.
    🔴 CORRECTED 9-04 — "it clears the iron slot by 5 h 15 min" measured the wrong variable. That is plasma separation; what governs non-heme iron is pump inhibition, which is ~24 h and indifferent to the clock. The 6:00 AM iron previously sat 24 h after the prior dose (maximum acid recovery) and now sits 18 h 45 m after it — slightly more residual suppression, not less. Small, unquantified, and not a reason to move the PPI back: the meal-timing gain is far larger. 41 of 43 PPI patients with unexplained iron deficiency were unresponsive to oral iron; 95% responded to IV ⟨Boxer, eJHaem 2020 — abstract ⟨?⟩⟩, with hepcidin upregulation via AhR beyond the pH effect. ⚖ Counter-evidence stated: one series found PPI users repleted slightly better, and a 16-study review could pool nothing. Direction one-way, magnitude unquantified.
    📞 Portal message sent to Wancata 9/3 — indication, taper, whether the discomfort needs evaluation, and the timing change stated as made. The dose and the continuation decision are hers; the clock is not. Open item 91.
    ⚠ Named not acted on: the "faster onset, not more drug" Adderall × PPI effect now lands on XR-2 in this slot rather than XR-1 at 6:30 AM.
  • Mastic Gum 500 mg — 1 capsule✅ SWAP DONE — AND IT IS NUTRICOLOGY, NOT GRECO GUM ⟨N✓8-24 · label read⟩. NutriCology · Mastic Gum · Authentic Chios Mastiha, 240 veg caps. ✅ 2 caps = 1 g Pistacia lentiscus var. Chia resin → 500 mg/cap → 1,000 mg/day, Δ=0. ✅ var. Chia CONFIRMED — open item 41 closes on it. ✅ No oat fiber, no dicalcium phosphate → calcium 0 holds on a read list. ❌ "Filler-free" is STRUCK — HPMC, MCC, magnesium stearate, silicon dioxide (Mg contribution ~0.1–0.4 mg/day, negligible). ⚠️ No allergen-exclusion statement — "Hypoallergenic" is a claim, not a list; unverified gap on all three avoidances, no known exposure. See open item 73. ordered 8/11, not yet in hand. Pure Chios mastiha (Pistacia lentiscus var. Chia), 500 mg/veg cap, no fillers.
    ✅ Dose, count and slot unchanged: 500 mg × 2/day = 1,000 mg, one capsule per slot in either product. Same compound, same dose — no schedule change and no attribution window.
    🔴 California Gold Nutrition until the Greco bottle arrives. Contains oat fiber — not a violation (symptom-based avoidance, not celiac) but a real twice-daily exposure, and the label does not claim certified-gluten-free oats. Its label also states only Pistacia lentiscus — no Chios, no PDO; every clinical trial used Chios mastic.
    📌 The ~38 mg/day elemental Ca goes to zero on the swap. CGN carries ~19 mg/cap from dicalcium phosphate; Greco is filler-free. Only calcium source in the regimen, in no total, ~4% of a 1,000 mg RDA — and it was on board for the 8/7 serum Ca.
    🧪 Live indication is cardiometabolic ⟨N 8-11⟩, not the retired post-ERCP / ulcer / H. pylori set — see mastic-indication.    ⏳ next bottle → Vitacost Root2 Chios
  • ⚕️ 🆕 Adderall XR-2 and its paired L-Theanine have RETURNED to this slot ← 11:55 AM ⟨N 9-01⟩This reverses the 8/26 move and restores the placement that ran 8/15–8/26. xr2-slot-history gains a fourth entry. Adderall 70 mg/day Δ = 0 — this is a clock change, not a dose change.
  • ⚕️ Adderall XR-2 30 mg🔴 MOVED 11:55 → 11:15 ⟨N 9-01⟩ · 💧 FASTED AGAIN. 🔴 Adderall XR is TWO pulses, not one — a 50:50 mix of immediate- and delayed-release beads, the DR half releasing ~4 h after dosing (XR 20 mg QD was shown bioequivalent to IR 10 mg BID at a 4-hour interval). The label's single Tmax is their midpoint. Decomposed, the fed 11:55 placement peaked ~5:25 PM and ~9:25 PM — so 15 mg, 21% of the day's dose, was peaking at melatonin time, and nothing actually peaked at the "7:40 PM" this file carried. At 11:15 fasted the pulses peak ~2:15 PM and ~6:15 PM — the evening pulse moves 3 h 10 m earlier. ⚖ Cost, stated: XR-1's DR pulse peaks 1:30 PM and XR-2's IR pulse now peaks 2:15 PM — 45 min apart, re-creating the overlap the 5/28 move existed to smooth. That is accepted deliberately: the 2026 complaint is dips, not overload, and two pulses 45 min apart read as a ~30 mg plateau across 1:00–3:00 PM, which is the window Nate names. 🔴 🆕 CORRECTED 10-03 ⟨C·10-03⟩: that used the label’s fed 4 h lag. Fasted (~2.8 h), XR-1’s slow beads peak ~12:18 PM and XR-2’s fast beads ~2:15 PM — ~2 h apart, with a shallow trough ~12:30–2 PM between them, over the early part of the 1–3 PM dip he names. No clock moves on it; the levers are XR-2’s timing or the dose-shape ask (item 88). 📞 Tell Murage — a timing change, not an approval gate. 🔴 🆕 CORRECTED 9-21: the 4 h lag is the label’s fed-state figure, and a composite does not peak at the midpoint — the fasted Tmax (5.2 h) fits a lag near 2.8 h, so the late hump sits nearer ~5 PM than 6:15. Pantoprazole stopped 9/20, so this becomes testable — item 127. 📞 Routing ⟨N 9-16⟩: Murage is leaving Wright Mind — “tell Murage” now means whoever holds the Adderall script.
  • L-Theanine 200 mg — 🆕 moved with it ⟨N 9-01⟩Stimulant-paired. And 11:15 is the better slot on its own merits: at 11:55 it sat 5 min ahead of a front-loaded-protein meal, and theanine is a LAT1 substrate — that meal's large neutral amino acids are its one real competitor. Fasted removes them. Nootropics Depot — 1 cap.
11:45 AM
Pre-meal
  • 🆕 DAO Enzyme has LEFT this slot → 11:55 AM ⟨N 8-29⟩🔴 The −15 min rationale that sat here argued for −5 and concluded −15 — struck as a candidate ⟨C⟩ artifact, see dao-gastric-lead-time. ✅ Taurine does NOT follow it — see dao-slotmate-decoupling.
  • Taurine 750 mg powder · or 1,000 mg cap (2 × 500) — 🆕 pre-Meal 1 ⟨N 8-10⟩🆕 Redistributed ⟨N 8-10⟩ — six slots → five, three of them pre-meal. Day total is now 4,000 ⟨N 8-12⟩ (the 8:45 PM dose was restored 500 → 1,000); the 8-10 redistribution itself was total-neutral at 3,500. Taurine is glucose-dependent insulinotropic via TauT in β-cells, so it is dosed ~30 min ahead of the excursion rather than with it (Tmax ~1.5 h).
11:55 AM
5 min pre-meal · stimulant
  • 🧫 DAO Enzyme 1 cap · #1 of 4 — 🆕 MOVED 11:45 → 11:55 ⟨N 8-29⟩Seeking Health DAOgest® 4.2 mg, 30,000 HDU ⟨N✓8-15⟩. ⏱ ≈5 min before Meal 1; ≈2 min before the first bite is the target. Small sip of water, then start eating. Free of egg, fish, gluten, GMO, milk, peanut, shellfish, soy, tree nut, wheat — the only recent product naming all three avoidances.⏳ next bottle → Pure Encapsulations DAO — open it onto the first bite
  • 🔴 🆕 ADDERALL XR-2 AND ITS PAIRED L-THEANINE HAVE LEFT THIS SLOT → 11:15 AM ⟨N 9-01⟩This slot is now the DAO capsule only. Derivation lives at the 11:15 AM slot and is not duplicated here. ✅ The DAO capsule does NOT follow them and does not move — its placement is pinned to the meal, not the stimulant; the two were only ever co-timed incidentally, which dao-gastric-lead-time established when the −15 min "ceiling" argument was struck.

🔴 SUPERSEDED IN FACT 9-01 — the historical claim below stands as written and the geometry moved. XR-2 returned to 11:15 AM fasted ⟨N 9-01⟩, so the fed-state arithmetic in this block describes a placement no longer running. Kept because it is the derivation the 9/1 two-pulse decomposition corrects. Its "~7:40 PM peak" is a midpoint between two bead pulses, not a peak.

🔴 ABSORPTION CHECK RUN AND SHOWN — THE CONSEQUENCE IS LARGER THAN THE 40 MINUTES ON THE CLOCK ⟨C·8-26⟩. Five minutes ahead of the biggest meal of the day, taken with the first fatty bites, is functionally a fed dose.

Adderall XR's own label, at the 30 mg dose: "Food does not affect the extent of absorption … but prolongs Tmax by 2.5 hours (from 5.2 hrs fasted to 7.7 hrs after a high-fat meal)" for d-amphetamine ⟨FDA label, NDA 21-303 — read directly⟩.

📐 Former 11:15 fasted → d-amph peak ~4:25 PM. New 11:55 fed → peak ~7:40 PM. A ~3 h 15 m shift, not 40 minutes. XR-1 → XR-2 peak gap goes 4 h 45 m → 7 h 55 m.

✅ Calibrating the other way, and it matters: the 5/28 → 8/15 placement at 11:45 was also 15 min pre-meal and therefore also fed. He ran a fed XR-2 for roughly two and a half months. The 8/15 move to 11:15 was the anomaly. This is a restoration of a known state, not an experiment.

⚠ Watch: a peak near 7:40 PM sits against gabapentin at 8:45 PM, melatonin at 9:30 PM and sleep onset. If sleep latency changes, this is the first suspect — see open item 76. ✅ AUC and Cmax unchanged — a Tmax shift, not a dose change. 📞 Tell the prescriber: information, not an approval gate.

12:00 PM
Meal 1 — biggest, front-load protein
🥑 Fat-anchored — with the first fatty bites
  • Creon 2 + 2 caps — 🆕 RAISED ⟨N 9-09⟩. Creon 36,000 U/cap ⟨N 7-06⟩, prescriber Kuhlman. The 2+2 divide is ⟨C·9-09⟩, not stated.
  • Digest Basic 1 cap — Enzymedica — 🆕 LIVE from 10/23, first dose planned for dinner (his “I’ll open it today” ⟨N 10-23⟩; the meal ⟨C·10-23⟩), replacing PE Digestive Enzymes Ultra, whose remainder he is keeping as a reserve. Panel read on his own bottle 10/23. A function match, not like-for-like: Creon carries the lipase, protease and amylase (720,000 USP amylase at this meal), so this line’s job is the enzymes neither Creon nor his gut supplies — alpha-galactosidase and the fiber enzymes. The two are close where they overlap (alpha-galactosidase, cellulase) and differ in kind elsewhere; on alpha-galactosidase both sit below every trial dose ⟨C·10-23⟩. Watch: baseline B = a usual evening on PE, written 10/23; then gas and bloating each evening 10/24–11/6. Two 3s in a row, or by 11/6 more than half the evenings worse than B → the PE reserve goes back in and Digest Complete, 1 per meal, is the next bottle. 🆕 The morning NAC move takes 11/7 and its watch runs to 11/11, so the grape seed and DAO swaps wait until 11/12 — one at a time, and not while the Digest Complete fallback runs.
  • 🔴 TAU (Triacetyluridine) 40 mg ⟨?⟩ — #1 of 2 — 🆕 MOVED FROM 3:00 PM ⟨N 8-26⟩⚠ Not taurine.
    ⏱ WHY THIS SLOT — the spacing is the whole point. The two doses sat 3 h 30 m apart (3:00 + 6:30 PM), then 20 h 30 m of nothing. 12:00 PM + 8:00 PM is exactly 8 h — the interval the only human PK study actually dosed ⟨Weinberg, PLoS ONE 2011;6(2):e14709, PMID 21379380 — full text read, Methods + Tables⟩.
    📐 THE FINDING: after six days of q8h dosing, baseline-adjusted AUC was identical to Day 1 (599.5 vs 606.2 µM·h, NS) — but the trough rose 4.7 → 31.1 µM, a 6.6× floor elevation (p<0.0001). Repeated dosing does not stack peaks; it lifts the floor, and only even spacing does it. t½ lengthens 3.4 → 5.3 h on repeated dosing (p=0.01). Tmax 1.3 h.
    ✅ Best absorption slot in the day for it: TAU's 4.2× advantage over pure uridine (Cmax 150.9 vs 36.1 µM) exists because it is lipophilic and absorbed by passive diffusion — no pyrimidine transporter needed. This is the fattiest meal.
    🔴 CORRECTS A rev 7.55 ERROR, stated not hidden: 7.55 filed TAU under "water-soluble" at both meals because the divide was rebuilt before this pharmacology was checked. Same error class as the Quercetin Phytosome and PEA misfilings that rev fixed.
    🔴 DOSE STILL UNRESOLVED — open items 75 and 75b. ND's page reads 25 mg/capsule; this file says 40 mg. Read the bottle. And at either figure the dose is 131–210× below the studied exposure — see 75b.
    ❌ Not temporary — no reversal block. 🔴 It shares the 8:00 PM slot with the EGCG relocation (open item 79, reverts on iron's exit). TAU does NOT ride that trigger.
  • Omega-3 — Ultimate Omega One Daily, 1 softgelNordic Naturals · 1,075 mg omega-3 (EPA 562 · DHA 438) · rTG ⟨N✓8-06, label photos · current 9-15⟩. The second fish oil, Pro-Resolve, is at dinner.⏳ next bottle → Sports Research Triple Strength, 1 softgel
  • D3 5,000 IU + K2
  • 🆕 Urolithin A 500 mg — Timeline Mitopure, 2 softgelsONCE DAILY · this slot only ⟨N✓9-05⟩🔴 The 1,000 mg/day was two products, not a dose. Timeline (2 softgels = 500 mg) plus Perpetua.Life Liposomal (1 cap = 500 mg); both lines read “Urolithin A 500 mg” with no brand. Day total 1,000 → 500 mg.
    🔴 The split was a ⟨C⟩ artifact. Its 6/29 rationale — “absorption is saturable, 500+500 beats 1000 once” — was uncited and was scoped to a 1,000 mg total that never existed. A 5/17 session had already concluded the opposite, citing the trial protocols.
    ✅ Why here: 500 mg once daily is what ATLAS randomised (ages 40–65); no trial has ever split UA; and UA is practically insoluble (~3.8% modelled bioavailability), so the lipid phase dominates — this is the biggest meal with the largest Creon divide.
    ⚖️ Flag, not a finding: UA inhibits pancreatic lipase in vitro (IC50 0.032 mg/mL, primary not opened). Andreux met its safety primary endpoint at 2–4× this dose with no fat-malabsorption signal. Watch for new steatorrhea — open item 98.
  • Curcumin (Nanocur) 500 mg
  • Boswellia 350 mg — Casperome® Boswellia Phytosome®ND · B. serrata resin, 25% triterpenoic acids, 1 cap. Carrier is sunflower lecithin — the soy gate does not engage here. Label lot BSPCS2042926. ⟨N✓8-11 · label-verified⟩
  • Holy Basil Force #2 of 3 — supercritical CO₂ in EVOO
  • Astaxanthin 12 mgCalifornia Gold Nutrition — AstaLif®, pure Icelandic astaxanthin. ⟨N 8-11⟩
  • ⏹ 🩸 EGCG — EXITED 10/1 ⟨N 10-01⟩ · it had left this slot for the 8:00 PM dessert ⟨N 8-26⟩ and was due back on iron’s exit; it returns nowhere🆕 Cut, not moved — egcg-cut. Items 77–79 close.📜 Was: EGCG has LEFT this slot → 8:00 PM dessert ⟨N 8-26⟩ — Meal 1 is the biggest and most iron-dense meal; dessert is the lightest.
  • Ubiquinol 100 mg
  • SerinAid PS 200 mgSoy-lecithin — lipid fraction, no trypsin inhibitors. Since rev 7.25 this is the general case, not an exception.
  • Milk Thistle 1 softgelLife Extension — Advanced Milk Thistle. ⟨? — brand ⟨N 8-11⟩; the SILIPHOS® 80 mg figure is from a 3/7/2026 session listing, not a label read⟩
  • 🆕 Quercetin Phytosome — 1 capsule —MOVED UP FROM WATER-SOLUBLE ⟨N 8-26⟩ND — Quercefit® (Indena), Sophora japonica, 250 mg ≈ ~100 mg actual quercetin. 🔴 A phytosome IS a phospholipid complex — the same delivery technology as the Casperome Boswellia and Siliphos Milk Thistle already in this group, and it was on the opposite side of the divide from both. See quercetin-dose-and-unit.
    🔴 Unit correction ⟨C-origin 2-27-2026⟩: a prior session recorded 400 mg/day by counting the whole complex as active — Quercefit is ~40% quercetin. Same class as the agmatine 43% gap and the NAC molar trap at 26%. ✅ HOLD at 1 cap. Do not raise. Quercetin ≥500 mg/day → diastolic −2.98 mmHg; <500 mg/day → −0.24, null ⟨Serban 2016 JAHA n=587; Huang 2020 n=896⟩. Grape Seed was cut at −2.80 against a floor of 57. ⚠ On an exposure basis the ~20× formulation may already sit in the ≥500 band — the mass number reads low and that reading is not safe to act on. ⛔ Mast-cell stabilization runs at 100 µM; achievable plasma is low single-digit µM — likely unreachable. The same exposure problem that cut resveratrol and, 🆕 with an iron cost on top, EGCG — both exited 10/1 ⟨N 10-01⟩.    ⏳ next bottle → CGN Quercefit
  • 🆕 PEA 400 mg —MOVED UP ⟨N 8-26⟩Palmitoylethanolamide is a fatty-acid amide — lipophilic, poorly water-soluble. It was misfiled at both Meal 1 and dinner.
  • 🆕 L-Glutamine 5 g — at the first bites ⟨N 10-29⟩Here for the timing, not lipid dependency — a free amino acid needs no Creon. Before the meal rather than after — on mechanism, not evidence: no study has compared them. Not with the 11:55 DAO sip, which wants a small sip; 5 g needs a glass — and whether that glass matters 2–5 min after the DAO is unknown ⟨?⟩. The pre-meal habit at noon (“pre-noon-meal” ⟨N 8-31⟩) is equally good and keeps the glass out of the DAO window. Moved up from “once you’ve eaten”, a grouping, never an absorption rule.
  • 🍄 Erinamax — left the regimen ~9/8 ⟨N 9-15⟩.Stopped over the dairy/soy question (label: “Contains: Milk, Soy”), with no indication on file. The Real Mycelium candidate closes with it unless reopened. The fruiting-body Lion’s Mane (6:30 AM · Meal 2) stays. The follow-up items about it are marked moot.
💧 Water-soluble — once you’ve eaten
  • ✅ ProBiota HistaminX 1 cap — STARTED 7/21Alone, single-variable, landed ≥1 week after the acid environment settled. Attribution window 7/21 → ~8/4 — this is the live trial. Nothing else new enters Meal 1 until it closes, which was a second independent reason the Erinamax dose step waited for post-8/1 (moot since 9/15 — Erinamax left ~9/8).
  • Glycine 1.5 g
  • 🆕 Sodium Chloride — #2 of 4 —MOVED DOWN ⟨N 8-26⟩A water-soluble salt with no fat requirement; it was heading the fat-anchored list.
  • OptiMSM 1,500 mg — #1 of 2⏳ next bottle → CGN OptiMSM flakes, ½ scoop (1.5 g)
  • NAC 1,000 mg — Nootropics Depot, pure — 🆕 12:30 PM DOSE FOLDED IN HERE ⟨N 8-26⟩#1 of 3. Stated reason: with food, to minimise GI upset. ✅ Daytime NAC UNCHANGED at 2,000 mg — 500×4 across four slots becomes 1,000 + 500 + 500 across three. No total moves. 🆕 Day total 3,800 ⟨N 8-11⟩ · 48.4 mg/kg · 69% of the ~70 mg/kg anchor · 106% of Lizzo's high arm. Ramp complete.⏳ next bottle → NOW NAC 1,000 mg, 1 tablet
  • TMG 500 mg — Life Extension🆕 Brand ⟨N 10-02⟩; capsule or powder ⟨?⟩. No purpose was ever written down — one is offered: a methyl donor his EPI can’t block, which spares choline ⟨C·10-02⟩ (tmg-indication). A fasting homocysteine for the ~10/21 draw is drafted as a request (follow-ups A9) — not yet sent or ordered.
  • Benfotiamine 300 mg
  • PQQ 20 mgLife Extension — PQQ disodium salt, generic. ✅ Dose basis RESOLVED 8/11: the trials, the EFSA authorisation and this label all express the dose as mg of the disodium salt — your 20 mg is the trial 20 mg. The 17.65 mg free-acid figure was correct but moot. Residual is QC, not chemistry: BioPQQ™ carries a named organism and ≥99.0% purity; generic does not.⏳ next bottle → CGN PQQ 20 mg softgel
  • Ergothioneine 30 mgToniiq — MitoPrime®, 98% L-ergothioneine, fermentation-derived. ⟨N 8-11⟩
  • Cognance 100 mg
  • ⏹ Spermidine — EXITED, stopped before 10/10 ⟨N 10-10⟩ · was 3 mg (CGN, 1 mg/cap × 3)🆕 Kept out after a 10/10 re-check ⟨C·10-10⟩: about 1 mg got a clean 12-month null (SmartAge); at 6 mg the one in-body signal is a week-2 B-cell autophagy rise with no between-group antibody difference, and the headline vaccine gains sit on an 8-vs-2 responder imbalance (Alsaleh 2026). Supersedes the 9/24 move to 6 mg ⟨C·9-24, adopted 9-24⟩. spermidine-exit.📜 California Gold Nutrition, from 100 mg rice germ extract (Oryza sativa) — not wheat, so the gluten avoidance does not engage. Tapioca-dextrin formulation; no MIRICELL™ on this lot ⟨label-verified 8-11⟩. dao-substrate-competition — shared polyamine transporter with agmatine, which brackets this slot at 10 AM and 1:45 PM. The DAO / agmatine note is moot.
  • Avmacol Extra Strength 1 tablet🆕 Nutramax, ≥35 mg glucoraphanin per tablet ⟨N 9-17⟩ — the “480 mg” this line carried was the blend weight; ~4–5 mg sulforaphane per tablet by the 10/4 estimate ⟨C·10-04⟩ — Extra Strength’s conversion is unpublished ⟨?⟩. SulfoMax was set aside 10/4 on potassium ⟨C·10-04, offered⟩.
  • Myo-Inositol 500 mg — NOW, 1 capBrand and strength ⟨N✓9-15⟩.⏳ next bottle → NOW powder, 500 mg
  • 🍇 Grape Seed 100 mg — Solgar, 1 veg cap ⟨N 9-09⟩ 🆕 ✅ LIVE ~9/4🔴 STARTED ~9/4 AHEAD OF THE DRAW ⟨N 9-11⟩ — gate not held; the day-14 step never applied and the resveratrol cut had not run, so net polyphenol load rose 180 mg — 🆕 until 10/1, when resveratrol and EGCG exited ⟨N 10-01⟩: ≈ −1,025 mg/day against 9/3. 3-week diastolic watch ~9/4→~9/25, no issue reported. Reverses the 8/11 cut; the BP case is unchanged and the reversal block is in master-regimen.md.⏳ next bottle → CGN Vitaflavan 100 mg — the diastolic watch reruns
  • ✅ 🍄 Turkey Tail 500 mg — #1 of 2 · LIVE ~8/11 ⟨N 8-11⟩ND powder or Real Mushrooms capsule — same dose either form. 1,000 mg/day, Meal 1 + Dinner — the pre-surgery placement, restored.
    ⚠ Pigment darkens stool cosmetically: stool colour is no longer a usable rebleed monitor. Substitutes: lightheadedness · unusual fatigue · resting HR trend · the iron panel.
12:30 PM
Cognitive
  • Magtein 667 mg — #2 of 3 · Nootropics Depot, 1 capCapsule ⟨N 9-15⟩ — was “cap or powder”.
  • Cognizin 250 mg
  • L-Theanine 100 mg — 🆕 new slot ⟨N⟩🆕 Now ~75 min after the 11:15 AM XR-2 ⟨9-01⟩, not ~35 min after an 11:55 one. Midday anchors run 11:15 → 12:30 → 1:45, gaps of 75/75 min. Its function changes from post-dose to mid-interval and it does not move. California Gold, AlphaWave® — 1 cap.
  • 🔵 NAC has LEFT this slot — folded into Meal 1 ⟨N 8-26⟩Stated reason: with food, to minimise GI upset. ✅ Daytime NAC UNCHANGED at 2,000 mg — 500×4 across four slots becomes 1,000 + 500 + 500 across three. No total moves.
    ✅ And one open question closes by removal, not by answer: rev 7.38 flagged the NAC ↔ Magtein pairing here as "new and worth one look." The pairing no longer exists — moot, not resolved.
1:30 PM
Blood pressure postprandial
  • 1 seated reading, 90 min after Meal 1 — through 7/30
  • Evening still runs lower in diastolic than midday🆕 Re-confirmed 8/11 on 64 readings (7/13–8/10): every sub-60 diastolic in the export is an evening reading; mornings never break 60. The old “falls to 115/50” line referred to 7/6 — that is now 5 weeks old and is the last sub-55 event on record.
  • ⚠ Stop rule — OR, not AND: below 100 systolic or below 55 diastolic → hold at 40 mg
1:30 PM
Between · ⚕ 🆕 moved 1:45 → 1:30 ⟨N 9-09⟩
  • ⚕ Adderall IR-2 5 mg — 🆕 MOVED 4:00 PM → 1:45 PM ⟨N 8-30⟩🔵 A consequence of the 8/26 XR-2 move, not a new idea. The 4:00 PM slot was correct while XR-2 sat at 11:15 AM fasted → d-amph peak ~4:25 PM — the IR covered that decline. XR-2 is now 11:55 AM FED → peak ~7:40 PM ⟨ADDERALL XR® label, NDA 21-303 — read⟩, so a 4:00 PM IR (Tmax ~3 h → peak ~7:00 PM) had begun co-peaking into the evening against gabapentin 8:45, melatonin 9:30 and sleep. ✅ At 1:45 PM the IR peaks ~4:45 PM — the two peaks de-stack by ~2 h 55 m and 5 mg of amphetamine leaves the evening. 🔵 1:45 over 2:00/2:30 is a STRUCTURAL choice — existing anchor, theanine consolidates, taurine keeps a 60-min gap to the 2:45 dose; 15 min against a ~3 h Tmax is noise. 📞 Tell Murage — timing, not approval. Dose and 70 mg/day untouched. See ir2-slot-history. 🔴 🆕 STALE PREMISE, 9-21: the ~7:40 PM peak this leans on ended 9/1 — XR-2 is back at 11:15 fasted (composite ~4:25 PM), so IR-2’s ~4:30 PM peak lands on it. The 1:30 slot stands on Nate’s felt need ⟨N 9-09⟩, not on this figure.
  • L-Theanine 200 mg — 🔴 🆕 THE 8/30 CONSOLIDATION TO 400 mg IS REVERSED ⟨N 9-01⟩200 stays here; 200 returns to 4:00 PM. Day total unchanged at 1,500; dose count 9 → 10. Open item 84 CLOSES. 📐 The defect was in the intervals and no check looked at them: theanine's elimination t½ is ~65 min (Tmax ~48 min), so a 400 mg dose here peaks ~2:35 PM and is spent by ~4:30 — the consolidation replaced two even 2 h 15 m gaps with one 4 h 30 m gap, the largest daytime interval in the schedule by more than double. ❌ The efficiency argument was looked for and does not exist: plasma AUC rises dose-dependently across 50/100/200 mg and no human PK at 400 mg was located. The case is coverage, and only coverage. Nootropics Depot — 1 cap.
  • 🆕 Taurine 500 mg — MOVED FROM 4:00 PM ⟨N 8-30⟩Its indication is IR-pairing, so it follows the IR. Tmax ~1.5 h → peaks ~3:15 PM, riding the IR's ascent toward its ~4:45 PM peak — same relationship it had at 4:00 PM, 2 h 15 m earlier. ✅ PAT1 checked, and the "cleanest slot" property SURVIVES: this slot carries no PAT1 substrate — ALCAR is OCTN2, agmatine is a polyamine, theanine is LAT1. Nearest glycine is 1 g at Meal 2, 75 min behind. ⚠ One new proximity: taurine against itself, 500 here and 750 at 2:45 — Tmax flattening, not AUC loss, and a flatter curve suits the glucose leg. Day total unchanged at 4,500.
  • 🔵 Agmatine Sulfate 250 mg — #3 of 4 — starts 8/7~1 h 45 m past Meal 1 → clear of the Meal 1 spermidine — 🆕 moot: spermidine exited 10/10 ⟨N 10-10⟩.
  • ALCAR 500 mgAfternoon spacing 4 h / 3¾ h / 3¼ h. Total 2,500 mg/day. Why four doses has never been written down — alcar-split-rationale ⟨?⟩.
  • Lemon Balm 300 mg (PRN)Vitacost — Cyracos® ⟨N 8-11⟩
1:45 PM
Optional
  • ☕ 🆕 Coffee — decaf + 1 shot caffeinated — OPTIONAL ⟨N 8-26⟩≈65–80 mg caffeine (a single espresso shot runs ~63–75 mg; decaf adds ~2–5 mg).
    ✅ 2:00 PM is the one timing that was actually tested. Morck measured three positions against the same meal: coffee with the meal cut non-heme iron absorption 39% (8.12% → 4.58%); coffee 1 h after was worse (→2.25%); coffee 1 h BEFORE produced a decrease that was NOT statistically significant ⟨PMID 6402915 — results read ⟨?⟩⟩. 2:00 PM is exactly 1 h before Meal 2 — the non-inhibitory position. ⚠ Population was iron-replete; the relative timing should transfer, the absolute numbers will not.
    ⚠ RLS and caffeine — raised once, honestly, not as a gate. The clinical convention is to limit afternoon caffeine in RLS, but the primary literature is thin: one low-tier case report plus a cross-sectional study in medical students aged 18–30 that actually found higher caffeine associated with lower reported RLS intensity while worsening sleep — and poor sleep then worsened RLS. The better-supported pathway is indirect: caffeine → sleep disruption → RLS. Per brief item 9, the burden sits with the claim.
    📐 t½ ~5 h → ~25–30 mg still on board at the 9:30 PM melatonin. ⚠ Lands in the same window as the XR-2 Tmax shift — open item 76, not separable.
    ✅ BP: the 1:30 PM reading is 30 min before this drink and the 8:00 PM reading is 6 h after — neither is inside the acute caffeine window.
    🔴 THE ADDERALL-IR SENTENCE HERE IS STRUCK ⟨C·8-30⟩ — the premise is unsupported and the mechanism was in the wrong compartment. It read: "the 4:00 PM IR is 2 h downstream … 2 h is adequate separation." ❌ Coffee is not on Adderall's label acidifier list (that names glutamic acid HCl, ascorbic acid, ammonium chloride, sodium acid phosphate) ⟨NDA 011522 — read⟩, and the source cited for it calls the effect understudied, significance unknown ⟨Carlat 2018 ⟨?⟩⟩. 🔵 The real pH effect is RENAL, not gastric, and it is large: t½ 7–14 h in acidic urine vs 18–34 h in alkaline, ~7 h per pH unit ⟨Änggård 1973 — ⚠ amphetamine-psychosis patients, high dose; mechanism transfers, numbers do not⟩. 🔴 And beverage pH does not predict urine pH — orange juice at pH 3.64 produced ALKALINE urine ⟨PMID 3940208 ⟨?⟩; coffee untested⟩. ⚖ Calibrated both ways: this equally removes any reason to keep the IR away from this slot. ✅ The live interaction is pharmacodynamic — caffeine and IR curves overlap the same whether the drink is 15 min before or after, so ordering cannot fix it. 🔵 This slot stays at 2:00 PM because IRON pins it (Morck), not Adderall. The IR is now 15 min upstream, deliberately and costlessly. See coffee-ir-acidity-premise.
2:45 PM
Pre-meal
  • 🆕 DAO Enzyme has LEFT this slot → 2:55 PM ⟨N 8-29⟩✅ Taurine stays — dao-slotmate-decoupling.
  • L-Theanine 100 mg🆕 MOVED FROM 7:00 PM ⟨N 9-11⟩. California Gold, AlphaWave® — 1 cap. Pre-meal, so it keeps its LAT1 head start on Meal 2’s amino acids. This slot is now the structural twin of 5:45 PM. Derivation at the 2:45 PM slot in master-regimen.md.
  • Taurine 750 mg powder · or 500 mg cap — 🆕 pre-Meal 2 ⟨N 8-10⟩
2:55 PM
5 min pre-meal
  • 🧫 DAO Enzyme 1 cap · #2 of 4 — 🆕 NEW SLOT ⟨N 8-29⟩DAOgest® 4.2 mg, 30,000 HDU. ⏱ ≈5 min before Meal 2; ≈2 min before the first bite is the target.⏳ next bottle → Pure Encapsulations DAO — open it onto the first bite
3:00 PM
Meal 2 — folded
🥑 Fat-anchored — with the first fatty bites 🆕 DIVIDE ADDED — THIS SLOT HAD NONE ⟨N 8-26⟩
  • Creon 3–4 caps — 🆕 RAISED ⟨N 9-09⟩
  • Digest Basic 1 cap — Enzymedica — 🆕 LIVE from 10/23, first dose planned for dinner — see Meal 1.
  • Longvida (curcumin) 200 mgLipid-encapsulated — unambiguously fat-dependent. Completes the 1,200 mg/day.
  • D3 extra 2,000 IUFat-soluble vitamin.
💧 Water-soluble — once you've eaten
  • ⚕ Buspirone 15 mg — 2 of 2 · with the meal🆕 LIVE SINCE 9/17 ⟨N 10-01⟩ — food raises buspirone’s AUC ~84% and Cmax ~116% (label, n=8), so this dose carries the larger exposure and the peak. 15 + 15 beats 20 + 10 on the day’s exposure (~23.2 vs ~20.9 mg fed-equivalent) — buspirone-split. 🔁 Switch rule ⟨C·9-30, offered⟩: dizziness or blurred vision that is new or worse than on 7.5 × 2, in the ~2 h after this dose (gabapentin at 4:00 PM lists both) → 20 mg AM / 10 mg here, only if the tablets can make those doses (not 7.5 mg tablets).
  • Glycine 1 g
  • Ester-C 500 mg — collagen cofactor
  • NAC 500 mg — Nootropics Depot, pure — #2 of 3Added ~7/31 ⟨N⟩. Renumbered 8/26 when the 12:30 dose folded into Meal 1 — the dose itself did not move.
  • ⏱ 🆕 TAU has LEFT this slot → 12:00 PM Meal 1 ⟨N 8-26⟩Spacing, not dose. See the Meal 1 slot for the PK derivation.
  • Myo-Inositol 500 mg — NOW, 1 capBrand and strength ⟨N✓9-15⟩.⏳ next bottle → NOW powder, 500 mg
  • Avmacol Extra Strength 1 tablet
  • 🍄 Lion’s Mane 500 mg (#2)Real Mushrooms, beta-(1,3)(1,6)-glucan standardized (~300 mg). Water-soluble polysaccharide — no fat dependency, so placement is already right and does not move.
4:00 PM
Afternoon
  • 🔴 ADDERALL IR-2 AND TAURINE 500 LEFT THIS SLOT → 1:45 PM ⟨N 8-30⟩Derivation lives at the 1:45 PM slot. 🆕 L-Theanine 200 returned here 9/1 ⟨N 9-01⟩ — the IR and the taurine did not.
  • ⚕ GABAPENTIN 300 mg — #1 of 2 — 🔻 🆕 taper ⟨N 10-10⟩🆕 ½ of a 600 mg tablet. A self-taper from his existing fill ⟨N 10-01⟩: 300 + 300 from 10/7 ⟨N 10-07⟩, back to 300 + 600 by 10/10 ⟨N 10-10⟩. In the plan offered 10/1 the evening dose goes last; anxiety, poor sleep or sweating within ~48 h of a step, or the evening RLS urge returning → back up one step and hold ⟨C·10-01, offered⟩. gabapentin-taper.Was 600 mg ⟨N 8-15⟩. ⏱ 2–3 h ahead of ~7 PM symptom onset (Tmax 2–3 h). 🔴 Timing is NOT as prescribed — the dose is. Prescriber said "afternoon and evening"; both doses moved later on chronobiology, stimulant-collision and magnesium grounds. Absorption is saturable via LAT1 — ~60% BA at 300 mg, ~40% at 600, ~35% at 1600 — so the split is right and the two doses sit 4 h 45 m apart. 3 h 30 m clear of the 12:30 PM Magtein. See gabapentin-timing-rederivation.
  • L-Theanine 200 mg — 🆕 RESTORED HERE ← 1:45 PM ⟨N 9-01⟩Reverses the 8/30 consolidation; derivation at the 1:45 PM slot. ✅ The Adderall IR and Taurine 500 do NOT come back — only the theanine. Why 4:00 and not 5:00: against the post-move peaks (1:30 · 2:15 · 4:45 · 6:15 PM) a 4:00 dose peaks ~4:50 and runs to ~6:15 where the existing 100 mg takes over — continuous cover; 5:00 peaks ~5:50 and leaves 4:00–5:20 bare. ⚖ Cost, stated: rev 7.59 recorded that losing the theanine helped gabapentin here. Settled on this file's own arithmetic — 1.148 mmol theanine vs 3.504 mmol gabapentin = 32.8 mol% against dietary protein delivering tens of mmol and still raising gabapentin AUC +14%. ⚠ On gabapentin's exit this slot now SHRINKS, it does not disappear — the rev 7.59 "delete the slot" instruction is struck. Nootropics Depot — 1 cap.
5:00 PM
Between
  • Sodium Chloride — #3 of 4
  • ALCAR 500 mg
  • 🔵 Agmatine Sulfate 250 mg — #4 of 4 — starts 8/7Last one of the day — well clear of the 8:30 PM fast. Nothing lands at noon (spermidine — 🆕 exited 10/10) and nothing after 5 PM.
5:30 PM
Pre-dinner
  • Mastic Gum 500 mg — 1 capsule✅ NUTRICOLOGY MASTIC GUM — LIVE 8/24 ⟨N✓8-24 · label read⟩. Not Greco Gum — open item 73. 500 mg/cap, var. Chia confirmed, no oat fiber, no calcium filler. CGN contains oat fiber — see the 11:15 AM slot and Standing constraints.⏳ next bottle → Vitacost Root2 Chios
5:45 PM
Pre-dinner
  • L-Theanine 100 mg California Gold, AlphaWave® — 1 cap.
  • Berberine Phytosome 275 mg — 1 cap · #1 of 2Enzymedica · Berbevis® (Berberis aristata root, 28–34% berberine → 77–94 mg berberine per cap). 15 min before dinner. Live since ~8/1 ⟨N 9-15⟩ — this hub carried it as HELD (BP/anemia gates) until 9/15; it restarted ahead of that gate, at its established 550 mg/day. 1 cap per dose is inferred from the label serving, not stated ⟨?⟩. Label read from a vendor product-gallery image, not the bottle. Carrier includes pea protein and grape seed per Indena — amounts undeclared. Peanut not named (“nuts” is). CYP2D6 inhibitor — tell Murage; antimicrobial — tell Kuhlman before any breath test. Indication derived ⟨C·9-15⟩: glycemic and lipid support; the one matching RCT used twice this daily dose. Timing kept at 15 min before — no interval is evidence-backed, and six weeks of clean tolerability decide it. Full record: master-regimen.md, 5:45 PM.
  • DAO Enzyme left this slot at rev 7.58 — it sits at 5:55 PM now.✅ L-Theanine and Taurine both stay — dao-slotmate-decoupling. 🔴 Corrected 9/15: this line read “→ 6:25 PM” — true until dinner moved to 6:00 on 9/9 — and it showed in QUICK view as a move notation. 📌 The 8/15 “6:25 merged into 6:15” note is historical.
  • Taurine 750 mg powder · or 500 mg cap — 🆕 pre-dinner ⟨N 8-10⟩⚠ This is the one that lands in the evening hypotensive window (dinner-hypotensive-load, −8.3 mmHg diastolic, measured). Kept because the glycemic indication is meal-linked and the eating window is the evening — a real trade, not an oversight.
5:55 PM
5 min pre-dinner
  • 🧫 DAO Enzyme 1 cap · #3 of 4 — 🆕 NEW SLOT ⟨N 8-29⟩DAOgest® 4.2 mg, 30,000 HDU. ⏱ ≈5 min before dinner; ≈2 min before the first bite is the target.⏳ next bottle → Pure Encapsulations DAO — open it onto the first bite
6:00 PM
Dinner
🥑 Fat-anchored
  • Creon 2 + 2 caps — 🆕 RAISED ⟨N 9-09⟩. The 2+2 divide is ⟨C·9-09⟩.
  • Digest Basic 1 cap — Enzymedica — 🆕 LIVE from 10/23, first dose planned for dinner — see Meal 1.
  • Curcumin (Nanocur) 500 mg
  • Boswellia 350 mg — Casperome® Boswellia Phytosome®ND · sunflower-lecithin carrier. ⟨N✓8-11 · label-verified⟩
  • ⏹ 🍇 RESVERATROL BLEND — EXITED 10/1 ⟨N 10-01⟩ · the cut decided 8/15 runs from today🆕 From day 0 of the buspirone 15 mg step, not ~10/7: resveratrol raised buspirone AUC 33% at 1 g/day (Chow 2010; untested at 250 mg), and clearance recovers over days to ~2 weeks — cut now, that recovery lands before the step’s 2–4 week judgment rather than across it. Re-checked 9/30: “SIRT1 falsified” overstated it (contested, in vitro); the verdict stands — resveratrol-cut. Riders leave with it: quercetin ~250 → ~100 mg/day · fisetin → 0 · grape + blueberry → 0.📜 Was: Resveratrol blend — 🚫 CUT DECIDED ⟨N 8-15⟩ · ⏳ executes after the draw (9/22) and after the off-PPI Adderall read (~10/1) ⟨C·9-21, offered⟩. The notes below are the pre-10/1 record, kept verbatim — “SIRT1 falsified” is amended above.✅ ⟨?⟩ CLOSED — label read 8/15: trans-resveratrol 250 · quercetin 150 · grape + wild blueberry 85 · fisetin 10. ⏳ Not today: 11 tests overlap the two orders and form a paired series — subtracting a compound 6 days out breaks it. Sequencing, not doubt. ⚠ Three riders leave with it: quercetin −150 · fisetin −10 · grape+blueberry −85. 🔴 That grape is grape FRUIT, not the grape SEED cut 8/11 — grapeseed-cut is unaffected. Grounds are the unworthy limb of burden-of-proof: SIRT1 mechanism falsified, null in T2D meta-analyses, and the one phenotype-matched mechanism misses on exposure by 40–600×. See resveratrol-cut.
  • Vitamin E 200 IU — NOWLow-dose cap held deliberately: weak vitamin-K antagonism, no tocotrienol megadose.
  • SPM Pro-Resolve 1 softgel — Pure EncapsulationsStarted ~9/15 ⟨N✓9-15⟩. 560 mg omega-3 · EPA 225 · DHA 200 · DPA 45 · 300 µg SPM precursors ⟨N✓8-06⟩ — a second fish oil, so it rides the Creon. Kept at dinner: Meal 1’s larger Creon dose, the one reason to move it, ended 9/09. Oil form unconfirmed (open item 123).
  • Zinc / Copper 15 / 1 mgAnastomotic healing. Copper is the DAO metal cofactor — 15:1 sits AT the 8–15:1 edge, not past it. Serum Cu + ceruloplasmin added to the 8/1 draw.
  • Ubiquinol 100 mg
  • SerinAid PS 100 mg
  • Holy Basil Force #3 of 3 — EVOO base, meal-anchored
  • PEA 400 mg🆕 — MOVED UP ⟨N 8-26⟩. Fatty-acid amide; misfiled here and at Meal 1.
  • 🆕 L-Glutamine 5 g — at the first bites ⟨N 10-29⟩Here for the timing, not lipid dependency; not with the 5:55 DAO sip — see Meal 1. It sits 15 min after the 5:45 theanine — see the 8:30 slot. Was “once you’ve eaten”, flagged “the live mucosal-integrity agent — and the real DAO lever” ⟨C·7-22⟩; the DAO link is mechanism only.
💧 Water-soluble — once you've eaten
  • ✅ MegaSporeBiotic 1 cap — STARTED 8/5 ⟨N⟩1 cap with dinner. ✅ Label-correct and no change recommended — Microbiome Labs directs 1 cap with food, stepping to 2/day at week 3. Spore-based Bacillus survives gastric acid and bile by design, so Creon is not a concern, and dinner keeps it well clear of the Meal 1 ProBiota. ⚠ Do not step to 2 caps during the NAC/Turkey Tail window — its listed side effects (cramping, loose stools) are the exact signal those are being read on. Earliest sensible step is after the 8/14 NAC watch closes.
  • Glycine 1.5 g
  • ⏱ 🆕 TAU has LEFT this slot → 8:00 PM dessert ⟨N 8-26⟩Both doses moved; the pair is now exactly 8 h apart where it was 3 h 30 m. See Meal 1.
  • OptiMSM 1,500 mg — #2 of 2⏳ next bottle → CGN OptiMSM flakes, ½ scoop (1.5 g)
  • NAC 500 mg — Nootropics Depot, pure — #3 of 3Renumbered 8/26 when the 12:30 dose folded into Meal 1 — the dose did not move.
  • TMG 500 mg — Life Extension
  • Magtein 667 mg — #3 of 3 · Nootropics Depot, 1 capCapsule ⟨N 9-15⟩ — was “cap or powder”. Gabapentin-era home ⟨N 8-15⟩; returns to 7:00 PM on gabapentin exit. 🔴 Back on this list 9/15 — the view had dropped it; taken here all along ⟨N✓9-15⟩ (open item 120).
  • Mg Bisglycinate 200 mg elementalGabapentin-era home ⟨N 8-15⟩ — returns to 8:45 PM on gabapentin exit. 200 mg is ELEMENTAL ⟨N✓8-12⟩ and carries 1,235 mg glycine. 🔴 Back on this list 9/15 — the view had dropped it; taken here all along ⟨N✓9-15⟩ (open item 120).
  • 🍇 Grape Seed 100 mg — Solgar, 1 veg cap ⟨N 9-09⟩ 🆕 ✅ LIVE ~9/4🔴 STARTED ~9/4 AHEAD OF THE DRAW ⟨N 9-11⟩ — #2 of 2; see Meal 1 for the full record. Reverses the 8/11 cut; the BP case is unchanged and the reversal block is in master-regimen.md. 🔴 Listed at 8:45 PM in this view until 9/15; master-regimen.md has had it at dinner since ⟨N 9-09⟩, and that is where it has gone ⟨N✓9-15⟩ (open item 120).⏳ next bottle → CGN Vitaflavan 100 mg — the diastolic watch reruns
  • ✅ 🍄 Turkey Tail 500 mg — #2 of 2 · LIVE ~8/11 ⟨N 8-11⟩Second of two. Pre-surgery placement restored.
  • ⏹ 🧯 PRN reflux rescue — CUT 10/10 ⟨N 10-10⟩Gaviscon Double Action and famotidine are out; only the pantoprazole restart triggers stay — 11:15 AM. The full record is in the archive (rev 7.82).📜 PRN · Gaviscon Double Action 20 mL ~30 min after dinner · famotidine 20 mg for breakthrough (max 2 a day). Reflux rescue while pantoprazole is stopped (9/20), through ~10/11. PRN — no totals line. Double Action per 10 mL: sodium alginate 500 · sodium bicarbonate 213 · calcium carbonate 325 mg — no potassium, aluminium or magnesium; 20 mL matches the alginate of the trial’s 10 mL of Advance. ~30 min after dinner keeps it clear of Adderall (its label: avoid antacids) and 2 h 15 m ahead of the 8:45 PM gabapentin. Full block: master-regimen.md, 11:15 AM.
  • Berberine is NOT taken with dinner ⟨N 9-15⟩.This line read “HELD 7/10 (#2 of 2)”. His practice since ~8/1 is 15 min before dinner (5:45 PM) and 15 min before dessert (7:45 PM).
7:00 PM
Evening
  • ⚠ NOT TAKEN HERE — Magtein 667 mg #3 of 3 sits at the 6:00 PM dinner ⟨N 8-15⟩.🔴 Corrected 9/11 ⟨9-11⟩ — at rev 7.67, 7.68 or 7.69; which of the three is not recorded (until 9/15 this line read “rev 7.70”, a stamp bump that landed on history): this was a bare <li>, so QUICK view rendered a dose that has not been taken here since 8/15 while its explanation sat in a hidden .sub directly beneath it. Fixed by MARKUP, not deletion — Full view keeps it, Quick view does not, and the two views cannot disagree. It returns here on gabapentin exit.
  • L-Theanine 100 mg🔴 RESTORED at rev 7.69 ⟨N 9-11⟩ after rev 7.68 removed it for one hour to fund the 2:45 PM dose. Both now run — day total 1,500 → 1,600, dose count 10 → 11. California Gold, AlphaWave® — 1 cap. Ledger split: this one is a RESTORATION of an established dose; the 2:45 PM one is the indicated INCREMENT.
  • ⚠ MagteinMOVED OUT of this slot to the 6:30 PM dinner ⟨N 8-15⟩Gabapentin-driven. Reverts to 7:00 PM on gabapentin exit — see the restore block.
7:45 PM
Pre-dessert
  • Berberine Phytosome 275 mg — 1 cap · #2 of 2Enzymedica · Berbevis®. 15 min before dessert. Live since ~8/1 ⟨N 9-15⟩ — this hub carried it as HELD until 9/15. Full record at 5:45 PM.
  • Gymnema moved to the 8:00 PM dessert, once you’ve eaten ⟨N 9-15⟩.Its line and derivation are at the dessert slot.
7:55 PM
5 min pre-dessert
  • 🧫 DAO Enzyme 1 cap · #4 of 4 — 🆕 NEW — FOURTH CAPSULE ⟨N 8-29⟩✅ Closes the dessert gap dao-per-meal-logic has named since rev 7.45. 🔴 ⚠ Do not judge this one on felt effect — the 8:00 PM slot carries NAC 1,800 mg, 47% of the day’s NAC (🆕 1,200 mg, 32%, from 11/7), and acetylcysteine is a documented DAO inhibitor at >20%. See dao-nac-thiol-collision and open item 83.⏳ next bottle → Pure Encapsulations DAO — open it onto the first bite
8:00 PM
Blood pressure postprandial
  • Take before dessert. 1 seated reading, 2 h after dinner🆕 Read “90 min after dinner” until 9/15. Dinner moved 6:30 → 6:00 on 9/09 and this clock was held at 8:00 PM on purpose, so the offset is now 2 h.
  • Dinner carries the hypotensive load Meal 1 no longer doesCurcumin, magnesium and grape seed #2. 🆕 Read “quercetin” until 9/15 — quercetin sits at Meal 1 — and “resveratrol” until 10/1, when it exited ⟨N 10-01⟩.
8:00 PM
Dessert — light
🥑 Fat-anchored — with the first fatty bites 🆕 DIVIDE ADDED — THIS SLOT HAD NONE ⟨N 8-26⟩
  • Creon 3–4 caps — 🆕 RAISED ⟨N 9-09⟩. 🔴 Corrected 9/15: this line read “Creon 1 cap” from rev 7.65 to 7.70 — Meal 1, Meal 2 and dinner were raised here on 9/9 and the dessert line was missed. master-regimen.md carried 3–4 throughout.
  • Digest Basic 1 cap — Enzymedica — 🆕 LIVE from 10/23, first dose planned for dinner — see Meal 1.
  • Milk Thistle 1 softgelLife Extension — Advanced Milk Thistle. Siliphos phospholipid complex. ⟨? — see Meal 1⟩
  • 🔴 TAU (Triacetyluridine) 40 mg ⟨?⟩ — #2 of 2 — 🆕 MOVED FROM 6:30 PM ⟨N 8-26⟩ · ⏱ exactly 8 h after dose 1⚠ Not taurine. Rationale lives at Meal 1 and is deliberately not duplicated. Short form: q8h is the interval that raised the trough 6.6×; 3 h 30 m raised nothing.
    ⚠ Honest cost: dessert is light on fat, which matters for a lipophilic prodrug. Spacing is evidenced; the fat effect is mechanism-level and unmeasured. Creon + Digestive Enzymes are still here, so lipase is present.
    🔴 Does NOT share the EGCG reversal trigger (open item 79). TAU stays here regardless.
💧 Water-soluble — once you've eaten
  • ⏹ 🍵 EGCG — EXITED 10/1 ⟨N 10-01⟩ · cut, not moved🆕 Life Extension Decaffeinated Mega Green Tea Extract — ≈326 mg EGCG, ≤3.6 mg caffeine per capsule (maker’s spec ⟨?⟩). No indication survived a search: pancreatic work at 5–25 µM against ~0.3–0.5 µM reachable; MIRACLE missed its primary at this dose (underpowered); HbA1c −0.18% in T2D and obesity. Against it: −27% non-heme iron at 300 mg in low-iron women, now that food is his only new iron. The liver did not decide it. egcg-cut; items 77–79 close. Catechins, if wanted: the 9:00 AM green tea. 🆕 rev 7.81: the daily green tea is at 8:00 AM, cold-brewed ⟨N 10-01⟩. 🆕 rev 7.82: the tea exited 10/10 ⟨N 10-10⟩ — no EGCG in any form.📜 Was: EGCG ≤400 mg — moved here from Meal 1 ⟨N 8-26⟩ — with food, never fasted. The notes below are the pre-10/1 record, kept verbatim — items 77–79 have since closed (caffeine ≤3.6 mg; the indication was searched and none survived).🔴 The claim that prompted this does not survive. A parallel thread wrote that tea catechins are a stronger iron inhibitor than coffee and that this was "a larger iron leak than the coffee ever was." That is compound-level reasoning applied to a purified-extract dose — adversarial brief item 11.
    📐 Searched at the strength actually held: purified EGCG 150 mg → 14% relative reduction, NOT significant; 300 mg → 27% (p=0.0002) ⟨Ullmann, TEAVIGO 94% crystalline EGCG, Phytomedicine 2005;12:410–15 ⟨?⟩⟩ — against black tea at 79–94%. At ≤400 mg this is ~30–35% on ONE meal — a third to a half of what was asserted, and coffee is the stronger inhibitor per serving, not the weaker.
    ✅ The 300 mg arm ran in women with low iron, so it transfers to ferritin 10. ❌ But Ullmann's "does not impair" conclusion was scoped to normal iron stores — that phrase is not imported.
    ✅ Why dessert and not fasted: Meal 1 is "biggest, front-load protein" — the most iron-dense meal; dessert is the least. 🔴 A fasted slot was checked and rejected — fasted intake raises free-catechin bioavailability and hepatic signals cluster at ≥800 mg bolus; ≤676 mg fed or fasted showed no hepatic AEs, and 756 subjects at ≤316 mg showed no transaminase elevation ⟨EFSA 2018;16(4):5239; UK COT 2024 ⟨?⟩⟩. A fasted slot would raise Cmax for zero iron benefit — fasted slots contain no dietary iron to protect. 🛑 6:00 AM is disqualified outright: that is where the iron is.
    ⚠ ⟨?⟩ The caffeine content of this capsule is unrecorded in every rev. At noon that did not matter; at 8:00 PM it does — open item 77.
    🔴 And EGCG still has no indication anywhere in this file — open item 78.
  • ✅ NAC bolus — NOW 600 × 3 = 1,800 mg · 🆕 RAMP COMPLETE ⟨N 8-11⟩⏳ from Sat 11/7: 600 × 2 = 1,200 mg — one capsule moves to 6:00 AMThe 8/14 step landed early. Day total 3,800 · 48.4 mg/kg · 69% anchor · 106% Lizzo high arm.
    ⚠ At 3 caps: Se 75 µg · Mo 150 µg — from here and nowhere else. ⏳ From 11/7: 50 · 100 here, 25 · 50 at 6:00 AM.
    🔴 This step, the 4th daytime capsule, and Turkey Tail all landed 8/11. All three are read on the same GI signal — a symptom in the next 3–5 days is unattributable by construction.
  • Gymnema 400 mg blend — 1 capNOW Gymnema Sylvestre Extract Blend — extract + maltodextrin, split undeclared; 50–148 mg gymnemic acids ⟨?⟩. 🆕 Moved from 7:45 PM pre-dessert ⟨N 9-15 · derived C·9-15⟩: with the meal rather than before it (the with-first-bite trial had fewer GI events than placebo; the before-breakfast trial had 52% looser stools), and after eating rather than with the Creon — a tiebreaker on an in-vitro lipase effect; the mouse data say the larger fat effect is transport, which no 15-minute shift avoids. Watch for oily or floating stool after dessert — first suspect. Peanut not on its exclusion line.
8:45 PM
Wind-down
  • Sodium Chloride — #4 of 4Later coverage blunts the overnight Na drop.
  • Taurine 1,000 mg — 🆕 RESTORED ⟨N 8-12⟩1 g → 500 at rev 7.35 → back to 1,000 on your stated sleep-support indication. Day total → 4,000 (+500 over the established 3,500) — scope limit engaged, indication named, open item 42. The overnight-coverage half stays retired — plasma t½ 1.0 h ⟨DOC: Ghandforoush-Sattari 2010, §2 methods, n=8⟩ — and is not what restored this. ❌ Nor is the GlyR-threshold argument: raised 8/11, withdrawn 8/12 — see taurine-glyr-threshold.
  • L-Theanine 200 mg Nootropics Depot — 1 cap.
  • Myo-Inositol 500 mg — NOW, 1 capBrand and strength ⟨N✓9-15⟩. 🆕 Stays here, not with dessert ⟨C·9-15⟩ — nothing located ties myo-inositol to food, co-ingested sugars and polyphenols cut its absorption in the only human data, and dessert now carries gymnema (EGCG exited 10/1). The old “half-life 5–8 h” reason was neonatal IV data and is struck.⏳ next bottle → NOW powder, 500 mg
  • ⚕ GABAPENTIN 600 mg — #2 of 2 — 🆕 ⟨N 8-15⟩🔻 🆕 600 mg here again by 10/10 ⟨N 10-10⟩ — it ran 300 from 10/7; in the plan offered 10/1 ⟨C·10-01, offered⟩ the evening dose goes last (gabapentin-taper).🔴 This slot is why the magnesium moved. 2 h 45 m clear of the 6:00 PM dinner Mg by the clock — about 2 h 15–30 m in practice, since the bisglycinate goes in once you’ve eaten. 🆕 Read “2 h 15 m … 6:30 PM” until 9/15. Divalent cations block LAT1 absorption — MgO cuts gabapentin AUC 43% ⟨PMID 22240839⟩. ✅ Co-administered L-Theanine 200 mg is a LAT1 substrate but is only 32.8 mol% of the dose, against dietary protein at tens of mmol that still raises AUC +14%.
  • ⚠ Mg BisglycinateMOVED OUT to the 6:00 PM dinner ⟨N 8-15, clock updated 9-09⟩🆕 200 mg is ELEMENTAL Mg ⟨N✓8-12⟩ — so this tablet also carries 1,235 mg glycine, which no prior rev counted. Not a dose change; an accounting one. See mg-bisglycinate-glycine.
9:30 PM
Melatonin
  • Melatonin 3 mg — ~30 min before sleep
  • 🔵 1 mg vs 3 mg resolves on rs10830963 (MTNR1B)It’s in the AncestryDNA raw file. Free, ten minutes, may prove the question moot.
9:45 PM
Pre-sleep — last action
  • Glycine 3 gSLEEP dose ⟨Yamadera 2007 · Inagawa 2006⟩ — 3 g pre-bed, PSG-confirmed. Placed for sleep; the NAC was moved to join it, not the reverse. Stays exactly here. 🆕 REVISED 8-15: the bisglycinate moved to dinner, so glycine after 8:30 PM is now 3,000 mg — 36.4% of the whole-day total. ⚠ A relocation, not a reduction — whole-day glycine is unchanged at 8,235, and this reverts on gabapentin exit.
  • Apigenin 100 mg — histamine, complements quercetinNootropics Depot. ⟨? — botanical source and purity not verified⟩
  • Lemon Balm 300 mgVitacost — Cyracos® ⟨N 8-11⟩

Daily totals · rev 7.86

Agmatine1,000 mg🔵 RESTORED ⟨N 8-6⟩, starts 8/7 post-draw. 4 × 250 mg sulfate ≈ 570 mg free base (57.0%) · 12.7 mg/kg. Reinstated on stated benefit — not on the burden rule, whose premise fails here. Dissent preserved in the registry.
Vitamin B616 mg25 mg P5P, Infini-B only. >EFSA UL (12), <US UL (100). Standalone P5P rejected 7/22.
NAC🆕 3,800 mgND 1,000 + 500 + 500 fed (Meal 1 · Meal 2 · dinner — the 12:30 PM dose folded into Meal 1 on 8/26 ⟨N 8-26⟩) + NOW 600 × 3 at the 8 PM dessert · 48.4 mg/kg · 69% anchor · 106% Lizzo high arm. ✅ Ramp complete ⟨N 8-11⟩. ⚠ +500 above the 3,300 target decided 8/3 — that increment has no indication on file. 🆕 Overtaken 8/14: open item 37 closed on his stated indication — Adderall smoother, mood better ⟨N 8-14⟩. 🔧 This row read “4 × ND 500 … 12:30 PM” until rev 7.83. ⏳ Meal 1’s 1,000 → NOW 1,000 mg tablet from the next bottle — plain NAC, no Se or Mo. ⏳ From 11/7: NOW 600 at 6:00 AM + 600 × 2 at 8 PM — total unchanged.
Selenium🆕 75 µg8 PM bolus only, at 3 caps. Zero from any other source. 19% of the 400 µg UL. ⏳ From 11/7: 25 µg at 6:00 AM + 50 µg at 8 PM.
Molybdenum🆕 150 µg8 PM bolus only, at 3 caps. 7.5% of the 2,000 µg UL. ⏳ From 11/7: 50 µg at 6:00 AM + 100 µg at 8 PM.
Glycine8,235 mg🆕 CORRECTED ⟨8-12⟩ — a measurement fix, not a dose change. Labeled 1.5 + 1 + 1.5 + 3 g = 7,000 · plus 1,235 mg obligate from Mg bisglycinate (200 mg elemental ⟨N✓8-12⟩). 104.9 mg/kg. Moves glycine from 89% → 105% of Baylor weight-scaled — a line every prior rev stated the wrong side of. Intake never moved. ⛔ Not a reason to raise NAC — see glynac-1to1-ratio. Indication ⟨N 8-12⟩: daytime doses distributed to pair with NAC timing.
Taurine4,500 mg🆕 THE 500 mgMOVED 4:00 PM → 1:45 PM WITH THE ADDERALL IR ⟨N 8-30⟩ — still six slots, Δ = 0. 🆕 Corrected 10/10: the 500 has sat at 1:30 PM since 9/09 ⟨N 9-09⟩, and the intervals are 4h45 · 1h45 · 1h15 · 3h00 · 3h00 · 10h15 (rev 7.66) — the clock and intervals below are pre-9/09. powder 750 + 750 + 500 + 750 + 750 + 1,000 · cap 1,000 + 1,000 + 500 + 500 + 500 + 1,000 — same total either form. 57.3 mg/kg. Meal-anchored 50.0% powder / 44.4% cap — unchanged, no meal-anchored dose moved. 🔴 Landing from 2:45 PM on RECOMPUTED: 66.7 → 55.6% powder, 55.6 → 44.4% cap (the 500 now lands before 2:45, not after). ✅ Dose CV unchanged at 19.2 / 33.3% — checked, not assumed: the multiset is identical and CV has no time term. 🆕 Intervals re-derived: 4h45 · 2h00 · 1h00 · 3h30 · 2h30 · 10h15 = 24h00 ✓ — the rev 7.35 figures were computed on 3,500 across five slots and are superseded. ⚠️ Now +1,000 over established across TWO named increments — open items 42, 71. 🆕 First safety anchor: Shao & Hathcock OSL 3,000 mg → 150%; highest RCT dose 150 mg/kg/d ≈ 11,775 mg → 38%; Galloway 7-day arm 56.8 mg/kg → 101%. No NOAEL exists — an OSL is where evidence is strong, not where harm begins. ⚠️ Taurine is vasoactive and this hub has never named it as one, against a 57 mmHg diastolic floor. It has run ≥3,500 through the whole 28-day record with no signal — monitored by the 8:00 PM reading, not a reason to hold. 51.0 mg/kg. ⚠️ +500 over the established 3,500 — this one IS an increase, so the scope limit engages. Indication named: sleep support ⟨N 8-12⟩. Reverses the 8/10 cut — yours reversing yours. Full indication ⟨N 8-10⟩: pancreas · glucose management · smoothing anxiety and Adderall.
TAU80 mg40 × 2 · ≠ Taurine
ALCAR2,500 mg1,000 + 500 + 500 + 500 · 6 AM / 10 AM / 1:30 PM 🆕 / 5 PM
L-Theanine1,600 mg🆕 11 doses — 1,600 since rev 7.69 ⟨N 9-11⟩: the 7:00 PM 100 restored and the 2:45 PM 100 added. 100+100+200+200+100+200+100+200+100+100+200 = 1,600 ✓. 🔧 This row read 1,500 / 10 doses from rev 7.69 to 7.81 — corrected at rev 7.82; the spine above has carried 1,600 throughout. History, as written at rev 7.66: 🔴 10 doses — REDISTRIBUTED AT rev 7.66 ⟨C·9-10⟩. 6:30 AM 200→100 · 9:00 AM 0→200 · 10:00 AM 100→0. Total and dose count both unchanged. The 8/30 consolidation is reversed: 400 mg at 1:45 PM → 200 at 1:45 + 200 at 4:00. 100+100+200+200+100+200+200+100+100+200 = 1,500 ✓. Largest single dose back to 200 mg; open item 84 closes. The TOTAL has never changed — only the spacing did.
Myo-Inositol2,500 mg1,000 + 500 + 500 + 500 · ⏳ NOW powder from the next bottle — same 2,500; a level ¼ tsp is 730 mg
L-Glutamine15 g3 × 5 g — 7:00 AM · first bites at noon · first bites at dinner · 🆕 kept at 15 g; the 15 → 5 g step-down retired ⟨N 10-29⟩ — re-derived ⟨C·10-29⟩: two IBS trials at 15 g/day; raised gut permeability measured in chronic pancreatitis (group data). Safety calibrated, not cleared (T3c; the 9/22 ALP flag). Was: “the live mucosal-integrity agent — also the real DAO lever” ⟨C·7-22⟩ — the DAO link is mechanism only.
Magtein2,001 mg667 × 3 · Nootropics Depot, 1 capsule per dose. Matches the 2 g/day trial dose.
Omega-3 (EPA + DHA)1,425 mg1,000 One Daily + 425 Pro-Resolve · DPA 45 · total omega-3 1,635 · ⏳ on the Sports Research bottle: EPA 915 · DHA 510 — EPA + DHA unchanged; total omega-3 1,615
Mg elemental~345–405Magtein ~144 + Mg bisglycinate 200 · single figure now that both forms match. 🆕 ✅ CONFIRMED unchanged ⟨N✓8-12⟩ — this range already assumed the 200 mg was elemental, and it is. Had it been compound weight the bisglycinate would contribute 28 mg and this range would fall to ~173–233.
HMB (CaHMB) · Amino-9 Essentials0🚫 CUT ⟨N 8-14⟩ — temporary recovery-window adds; window formally closed by Wancata 8/12 ("well healed incision", "OK for activity and diet as tolerated", 1-year follow-up). HMB was a bundle: it carried ~1,000 IU D3 + ~360 mg Ca, and both leave with it. Amino-9 never had a totals line. ⚠ With both EAA sources gone, the weighed-protein item is no longer optional.
Curcumin1,200 mgNanocur 1 g + Longvida 200
OptiMSM3,000 mg1,500 × 2 · ⏳ CGN OptiMSM flakes from the next bottle — ½ scoop (1.5 g) × 2
NR300 mg6 AM fasted · ⏳ Life Extension NAD+ Cell Regenerator (Niagen) from the next bottle
Synapsa Bacopa320 mgsingle AM cap · 🔧 read 360 until rev 7.83 — a records slip; the capsule is 320 · ⏳ CGN Bacopa (Synapsa) from the next bottle
Lion’s Mane1,000 mg500 × 2 · Real Mushrooms, fruiting body
🆕 Turkey Tail1,000 mg🆕 500 × 2 ⟨N 8-11⟩ — Meal 1 + Dinner. ND powder or Real Mushrooms cap, same dose either form. Closes the “no dose on file” gap. Carries no Se or Mo.
Mastic Gum1,000 mg500 × 2 · 1 capsule per slot ⟨N 8-11⟩ · NutriCology, live since 8/24 ⟨N✓8-24 · label read⟩ — no oat fiber, no calcium filler. ⏳ Vitacost Root2 Chios from the next bottle — re-read var. Chia on arrival. 🔧 This row described the 8/11 Greco order (“CGN until it lands”) until rev 7.83.
Vitamin E200 IUNOW · low-dose cap, weak vit-K antagonism
PEA800 mg400 × 2
Urolithin A500 mgMeal 1 only — 2 softgels, Timeline Mitopure
Boswellia700 mg350 × 2
Citicoline (Cognizin)500 mg250 × 2
Vitamin D37,000 IU🆕 Reduced from ~8,000 ⟨N 8-14⟩ — 5,000 (Meal 1) + 2,000 (Meal 2). The ~1,000 IU HMB bundle left with the cut. ⚠ The 8/7 panel’s 25-OH-D + serum Ca were drawn with the bundle on board — an on-HMB reading.
Cordyceps1,000 mg🆕 NEW LINE — LIVE 8/24 ⟨N✓8-24 bottle read⟩. Real Mushrooms CORDYCEPS-M, C. militaris extract, 500 mg × 2 caps, one per slot (6:30 AM + 10:00 AM). 12.7 mg/kg · 8% β-glucans. ⚠️ The one-cap-per-slot split is inferred from the recorded placement, not stated — ⟨?⟩ on the split only. Glucose-active — 🆕 the 9/22 glucose endpoints are an on-Cordyceps reading — and antiplatelet-adjacent: open items 69, 70.
Supplemental calcium≈ 65 mg🔴 🆕 CORRECTED AT rev 7.83 — ≈ 65 mg, NOT 0 ⟨C·10-13⟩: the Ester-C 500 mg at Meal 2 is calcium ascorbate (~55 mg Ca per tablet) and the iodine tablet carries ~10 mg from dicalcium phosphate. 🆕 NOW ZERO ⟨N✓8-24 · label read⟩ — the mastic swap executed. HMB carried ~360 mg/day and left 8/14; CGN mastic carried ~38 mg/day via its dicalcium-phosphate filler and the NutriCology replacement carries no calcium filler (HPMC, MCC, Mg stearate, silicon dioxide). The conclusion holds on a read excipient list — the prior derivation rested on an unverified "filler-free" brand attribution and was right by luck. The 8/10 serum Ca was drawn with that ~38 mg on board and remains a with-calcium reading. ❌ rev 7.40’s “the only calcium source in the regimen” was false — see hmb-bundle.
Sodium~1,560 mg⚠ Do not raise until the mechanism is known. In SIADH this is the wrong direction.
🩸 Iron (elemental)⏹ exited⏹ 🆕 EXITED 9/23 ⟨N 9-23⟩ — trigger (b), INFeD 1,000 mg; 0 mg/day. Before that: ⏸ HELD from 9/21 ⟨N 9-21⟩ — draw 9/22, IV iron 9/23; ~18 → 0 mg/day while held. The base stays 36 mg alt-day; re-entry after the infusion is a recheck decision. Before the hold — BACK TO 36 ⟨N 9-17⟩ — 2 × 18 mg elemental from NOW Ferrochel, 6:00 AM; ~18 mg/day averaged. The +36 increment (9/03–9/17) exited on reversal trigger (a). Read the unit: 18 mg elemental from 90 mg of the chelate — never record 90 or 180. Row added 9/03; this table never carried iron before.
⚕️ Pantoprazole⏹ 0⏹ 🆕 STOPPED 9/20 ⟨N 9-21⟩ — ran out; Wancata’s OK to stop. 🆕 PRN ladder cut 10/10 ⟨N 10-10⟩; resume triggers (corrected 10/8) at the 11:15 AM slot. Row added 9/03: 40 mg once daily, 11:15 AM, prescriber Wancata.
Adderall70 mgXR 60 + IR 10 · full prescribed · 🆕 clock unchanged — off the PPI the XR curve shifts later; read 9/24–9/30, decide ~10/1 (item 127). Murage is leaving Wright Mind ⟨N 9-16⟩ — FYIs go to whoever holds the script.
⚕️ Buspirone30 mg🆕 15 × 2 from 10/1 ⟨N 10-01⟩ — 7:00 AM fasted + 3:00 PM Meal 2 · live since 9/17 at 7.5 × 2, recorded 10/1 · 0.38 mg/kg · Rx — the milligrams are the prescriber’s · tablet strength ⟨?⟩ (item 136)
⚕️ Gabapentin🔻 900 mg🆕 300 at 4:00 PM + 600 at 8:45 PM ⟨N 10-10⟩ — a self-taper from his fill (300 + 300 from 10/7; 1,200 until then) · 11.5 mg/kg · the exit is the prescriber’s call · gabapentin-taper. Row added 10/10 — this table never carried gabapentin.
Telmisartan40 mgHolds. Reassess ~8/1.
Saffron30 mgND, Crocus sativus stigma, 7.5% crocins / 1.0% safranals · 6:15 AM
Panax GS15-4200 mgND, 1 cap · 🆕 6:00 AM ⟨N✓9-04⟩ — back from 8:00 after one day; the 9/03 iron-driven move was reversed (open item 93)
R-ALA (Na-R-ALA)300 mg🆕 6:00 AM fasted ⟨N✓9-04⟩ — back from 8:00 after one day; the 9/03 iron-driven move was reversed (open item 93)
Bilberry100 mgLE MirtoSelect, fruit, 36% = 36 mg anthocyanins · 10:00 AM
Gymnema400 mg🆕 8:00 PM dessert, once you’ve eaten ⟨N 9-15⟩. A 400 mg BLEND (label read 9/9) — 50–148 mg gymnemic acids ⟨?⟩.
MegaSporeBiotic1 capdinner · started 8/5
L-Citrulline · Chromium0🚫 CUT. Citrulline ⟨N 8-6⟩ — real BP case. Chromium ⟨N 8-6⟩ — mechanism mismatch. 🆕 Grape Seed ⟨N 8-11⟩ — Nate's decision, and an independent BP case supports it: 2016 meta (16 trials, n=810) systolic −6.08 / diastolic −2.80, against a 2 mmHg margin. Never carried a dose, so no total changes. 🆕 Grape Seed was restored ⟨N 9-09⟩ — its own row below; this row listed it as cut from rev 7.65 to 7.81.
🍇 Grape Seed200 mg🆕 Solgar 100 mg × 2 — Meal 1 + dinner ⟨N 9-09⟩, live ~9/4. The BP case against it is unchanged; its reversal block is at Meal 1 in master-regimen.md. ⏳ CGN Vitaflavan from the next bottle — a different extract, so the 3-week diastolic watch reruns on the switch. Row added 10/10.
🧂 Iodine150 µg🆕 NaturesPlus potassium iodide, 1 tablet, 7:00 AM ⟨N 9-09⟩, live ~9/4. Row added 10/10.
🆕 EGCG · Resveratrol blend0⏹ 🆕 EXITED 10/1 ⟨N 10-01⟩. EGCG — cut, not moved (egcg-cut). Resveratrol — the 8/15 cut runs from 10/1 (resveratrol-cut); its riders leave with it: quercetin ~250 → ~100 mg/day (Quercefit only) · fisetin 10 → 0 · grape + wild blueberry 85 → 0.
Berberine Phytosome550 mg🆕 275 × 2 (5:45 + 7:45 PM) — live since ~8/1 ⟨N 9-15⟩, recorded 9/15 = 154–187 mg berberine. Capsule count inferred ⟨?⟩.
Potassium0✅ 🆕 POTASSIUM VERIFIED CLEAR 8/14 ⟨N✓4⟩ — the VM chart’s KCl 801 mg/day is a stale entry; none is taken and the ARB constraint has never been breached. Chart entry still needs removing — open item 48.

DAO — what actually governs it

Ranked for this phenotype · B6 is not on the list

1. Substrate competition ⟨C·7-22 | i:in-vitro/porcine⟩ — 🔵 The agmatine arm returns 8/7. At 1 g/day it is the largest DAO-substrate load in the stack, crude molar load ≈ 50× dietary histamine. Caveat unchanged: in-vitro porcine — order-of-magnitude flag, not a measurement.

Transporter question closed 7/29 ⟨C·7-29 | DOC:Satriano-2001 · Gründemann-2003 · Winter-2011 · Ramos-Molina-2015⟩ — the Amino-9 collision is falsified. 🆕 (Amino-9 itself was CUT 8/14 ⟨N⟩ — this paragraph is historical.) Agmatine moves on the polyamine transporter (Km 2.5–44 µM) and OCT2/OCT3/MATE1, not the y⁺ cationic amino-acid system; arginine, lysine and ornithine were tested directly and do not compete. The real collision was Spermidine 3 mg at Meal 1 — shared polyamine route. 🔴 LIVE AGAIN from 8/7 — 🆕 moot from 10/10: spermidine exited ⟨N 10-10⟩. This is exactly why no agmatine dose lands at noon: 6:15 AM, 10 AM, 1:45 PM and 5 PM are all clear of the Meal 1 spermidine.

2. Mucosal integrity ⟨C·7-22 | i:villus + GI-disease⟩ — DAO is made by mature villous enterocytes. Post-Frey + Forrest III ulcers + EPI is the likeliest suppressor. Intervention already live: L-Glutamine 15 g/day.

3. Copper ⟨C·7-22 | m: 9/22⟩ — the actual metal cofactor. Zn:Cu 15:1 is at the 8–15:1 edge. 🆕 Measured 9/22: serum copper 93 (105 on 6/11), ceruloplasmin 27.5, CRP 0.68 — no acute-phase adjustment needed.

⚠ HISTORICAL ⟨8-15⟩ — NaturDAO left the regimen 8/15, replaced by Seeking Health DAO Enzyme. Retained because the reasoning still applies to any legume-DAO product: do not switch to NaturDAO Plus — it bundles P5P on the retired rationale. Legumactive is Pisum sativum + Lens culinaris (not grass pea → no β-ODAP concern), supplies catalase alongside DAO, and ~96 mg legume protein/day is ~3 orders below any Creon/trypsin-inhibitor concern.

What to expect

A principle, not a prediction

In T3c with retained C-peptide (1.4, June 2026) and ⟨assumed⟩ impaired glucagon counterregulation, a higher glucose floor with lower variance beats a lower mean with excursions you cannot feel or counter.

🔵 Gymnema is back in from 8/7 — glucose-active, so it drifts numbers down, the opposite direction to this principle. 🆕 Berberine has been in since ~8/1 ⟨N 9-15⟩ — also glucose-active, and present in every reading since. Citrulline is cut ⟨N 8-6⟩. If your numbers drift up slightly, that is still not a regression to correct.

⚠ This stands on glucagon-impairment, which is UNMEASURABLE (Garbacz 7/15). Keep it if you want it — but it is an assumption, not physiology.

Daily architecture · rev 7.86 · 2026-10-29 · one supplement per row · every total is an exact sum of the spine above