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rev 7.63 · live 9/01

Daily architecture

One supplement per row. The dot on the spine is now.

Names and doses only. Every annotation is hidden, not removed — this is the same markup as Full view, so the two cannot disagree. Iron is ALTERNATE DAYS. TAU is Triacetyluridine, not taurine.

Soy — activity-gated, not categorical

Kunitz and Bowman-Birk inhibit trypsin and chymotrypsin only — not lipase, and Creon is dosed in lipase units and titrated on fat absorption. The only surviving concern is CCK / protease-feedback at raw-flour scale. Yardstick — 🔴 NOW HISTORICAL, NOT LIVE ⟨C·8-15⟩: NaturDAO ~96 mg/day legume protein was cleared (32.1 mg × 3 tablets). That product left the regimen 8/15 and its porcine replacement carries ZERO legume protein. The number survives as the highest legume exposure this regimen has cleared in practice, but it is no longer a live intake and must not be cited as one — measure candidates against it as history, not as label presence. ⟨? | a — unsourced in every rev; not on the Creon FDA label⟩

5:55 AM
Blood pressure first action
  • 3 readings, one minute apart
  • Discard #1. Average #2 and #3. That is the number.
  • Sit 5 min · feet flat, back supported, no talking
  • Bare arm, cuff at heart level
  • Log to Apple Health
6:00 AM
Fasted
  • Infini-B — methylated B-complex 25 mg P5P = 16 mg B6🔴 DAO-“cofactor” rationale STRUCK 7/22. DAO is a copper amine oxidase (Cu · Ca · TPQ). PLP is the cofactor for histidine decarboxylase — histamine synthesis. B6 is not a DAO lever. Standalone P5P 50 mg rejected (would be 49 mg B6 ≈ 4× EFSA UL).
  • NR 300 mg
  • ALCAR 1 g (2 × 500)
  • 🆕 Holy Basil #1 of 3 — NOW, capsule (fine fasted)🔴 RESTORED to 6:00 AM ⟨N✲4 9-04⟩ — the 9/3 relocation is reversed. Rosmarinic acid is a genuine catechol iron-binder, but this is 1/3 of a capsule, never quantified in any rev, and a PPI is running. Capsule-scale polyphenol against a drug-level inhibitor.
  • 🆕 Panax Ginseng GS15-4 200 mg🔴 RESTORED to 6:00 AM ⟨N✲4 9-04⟩ — ND, 1 cap. Dose unchanged, total Δ = 0. rev 7.63 classed this as a "polyphenol-bearing capsule" and that was a category error: GS15-4 is a ginsenoside-standardised extract and ginseng’s principal actives are triterpene dammarane saponins, which lack the galloyl/catechol groups Hurrell’s inhibition runs on. See ginseng-polyphenol-class.
  • 🆕 R-Lipoic Acid (Na-R-ALA) 300 mg🔴 RESTORED to 6:00 AM ⟨N✲4 9-04⟩ — the falsified one. The paper rev 7.63 cited is "α-lipoic acid attenuates duodenal non-heme iron absorption via microRNA-mediated regulation of DMT1 in iron overloaded rats" ⟨Mol Biol Rep 2025⟩. ALA cut DMT1 protein without changing mRNA — post-transcriptional control of transporter density, not luminal chelation. A systemic change in transporter number cannot be defeated by a two-hour gap. See ala-iron-chelation.
  • 🩸 IRON — ferrous bisglycinate 72 mg elemental · 4 caps · ALTERNATE DAYS — 🆕 DOSE 36 → 72 mg ⟨N✓9-03⟩NOW Foods Ferrochel® (Albion) — 18 mg elemental/cap from 90 mg ferrous bisglycinate; the label does the conversion, so record 18, never 90. 120 caps = 30 doses ≈ 2 months at 4 caps (was 60 doses ≈ 4 months at 2). Why 2 caps: an n=480 RCT found 18 mg bisglycinate no different from placebo on ferritin at 12 weeks (vs 60 mg ferrous sulfate) — in iron-replete women, so it does not transfer cleanly here, but it establishes 18 mg as a maintenance dose. The dose with trial support is 25 mg; 36 clears it. Alternate-day because hepcidin stays up ~24 h after a dose. 🛑 SKIP FOR 48 h BEFORE THE ~8/21 DRAW — iron studies want ≥24 h clear. ⚠ Peanut is not on its allergen-exclusion line — open item 61. 🆕 THE LEDGER IS SPLIT ⟨N✓9-03⟩: the 36 mg base is established and protected; the +36 mg increment carries its own indication — a ~1,272 mg deficit with the IV route stalled, 36 mg sitting below the 40–80 mg alternate-day window Moretti and Stoffel tested, and alternate-day preserved because a single larger dose beats a split one on hepcidin. ⚠ Those trials ran in iron-depleted women 18–45 — the dose SHAPE transfers, the percentages do not. 🔄 Reversal: GI intolerance returns it to 36 mg alone; IV repletion retires oral iron entirely. It does NOT fire the three iron-exit relocations (open items 62, 79, 93). 🔵 ~12 months to close at 36 mg, ~7 at 72 — the file's old "~8 months" was gross absorbed and never netted basal loss.
6:15 AM
Cognitive
  • Magtein 667 mg — #1 of 3Cap or powder — same dose either form.
  • Synapsa Bacopa 360 mg — single AM cap
  • ✅ Saffron 30 mg — LIVE ~7/15 ⟨N⟩ND, Crocus sativus stigma extract, 7.5% crocins / 1.0% safranals, 1 cap. A returning member, not a new addition — see saffron-membership.
  • 🔵 Agmatine Sulfate 250 mg — #1 of 4 — starts 8/7 post-draw⚠ Sits 15 min ahead of telmisartan. You ran that pairing for months; the 5:55 AM series is pre-dose so it will not catch it.
6:30 AM
Morning Rx — fasted 🆕 bite cut 8/3
  • 🗑️ Creon + protein bite — CUT 8/3 ⟨N⟩Two hard-boiled eggs, removed with the fasting restart (8:30 PM → noon). No food, no lipase substrate — Creon goes PRN and returns automatically on any transitional snack, per the standing rule. Everything else in this slot is fine fasted.
  • ⏸ Telmisartan 40 mg🔴 "Fat-free window" rationale STRUCK 7/22. FDA label: food reduces AUC ~6% at 40 mg; Micardis may be given with or without food. The eggs were never a problem, and a fasted slot would raise exposure ~6% during a hold. No move. Records still list 80 mg — correct the stale figure.
  • Adderall XR-1 30 mg — now fastedLabel permits with or without food; a high-fat meal only delays Tmax. Onset slightly faster fasted. Prescribed — tell Murage the timing context changed.
  • Adderall IR-1 5 mg — now fasted — ACTIVE
  • Cognizin 250 mg
  • L-Theanine 200 mg
  • 🍄 Lion’s Mane 500 mg — #1 of 2Real Mushrooms — fruiting body, hot-water extract, β-glucans. Fine fasted. The fat-dependence premise (erinacine-lipophilicity) applies to Erinamax at Meal 1, not to this product.
  • 🍄 Cordyceps 500 mg — #1 of 2 · STARTED 8/24 ⟨N✓8-24⟩Real Mushrooms CORDYCEPS-M — organic Cordyceps militaris extract, 1,000 mg per 2-cap serving → 500 mg/cap → 1,000 mg/day, 12.7 mg/kg, β-(1,3)(1,6)-glucans 80 mg = 8%. 🔴 Species matters: Cs-4 (C. sinensis mycelium) carries almost all the human evidence; militaris carries the cordycepin and a much thinner trial base. 1,000 mg is the FLOOR of the studied 1,000–3,000 mg range. Cordycepin content not on the label — ⟨?⟩. Open item 74. ✅ Open item 69 CLOSED on a bottle read. 📌 The VM chart's cordyceps 1,000 was right — notable, since three other entries on that chart were stale. ⚠️ Three written restart conditions were not met: not last, not alone (four changes share 8/24), and not half-dose — half is 1 cap/day. Open item 70.
7:00 AM
Fasted · 🩸 tea moved out 8/17
  • Sodium Chloride 1 g Rx (~390 mg Na) — #1 of 4
  • L-Glutamine 5 g
  • Taurine 750 mg powder · or 1,000 mg cap (2 × 500)🆕 Cap form raised to 1,000 ⟨N 8-10⟩. No meal to anchor to inside the fast, so this slot serves the Adderall XR-1 / IR-1 onset only.
  • 🩸 Green tea / maté has LEFT this slot → 9:00 AM ⟨N 8-17, moved again 8-26⟩Tea polyphenols are among the strongest inhibitors of non-heme iron absorption, and 1 h behind the 6:00 AM iron dose is not enough separation. The drink moved; no dose changed and no total moved. ⚠ This reverts on IRON's exit, not gabapentin's — two temporary changes now run on different triggers. Open item 62.
8:00 AM
Fasted
  • 🔴 THREE ITEMS HAVE LEFT THIS SLOT → BACK TO 6:00 AM ⟨N✓9-04⟩Holy Basil #1, Panax GS15-4 200 mg, R-Lipoic Acid 300 mg. They were here for one day. No dose changed, all three totals Δ = 0. Derivation and the ⟨C⟩ ruling live at the 6:00 AM slot.
  • L-Theanine 100 mgCovers the XR-1 first pulse (~2–3 h post-dose). Plasma t½ ~1 h, so it does not stack with the 6:30 dose.
  • Lemon Balm 300 mg (PRN)Vitacost — Cyracos® ⟨N 8-11⟩
  • ⏸ 8:00 AM drug-peak BP slot — suspendedReinstate with any telmisartan change.
9:00 AM
Optional — pick ONE
  • 🆕 Green tea or maté — OR — coffee (caffeinated) — OPTIONAL ⟨N 8-26⟩🩸 Moved 8:00 → 9:00 AM ⟨N 8-26⟩; separation from the 6:00 AM iron dose goes 2 h → 3 h. L-Theanine and the PRN Lemon Balm stay at 8:00 — only the beverage moved.
    ✅ Coffee here is neutral-to-favourable vs tea on iron, which is the opposite of what was assumed: in the only direct head-to-head, coffee cut non-heme iron absorption 39% against tea's 64%, and coffee was significantly less inhibitory (ratio 0.59, p<0.001) ⟨Morck, Am J Clin Nutr 1983;37:416–20, PMID 6402915 — results read, methods not opened ⟨?⟩⟩.
    ⚠ Caffeine: 2.5 h after XR-1, ~3 h before the new 11:55 XR-2. Both BP readings (5:55 AM, 1:30 PM) sit outside the acute caffeine window — neither is contaminated.
    🔴 This line also fixes an HTML gap: rev 7.47 moved the drink to 8:00 AM in the markdown and never added it to any slot here. It has been missing from this page for eight revs.
10:00 AM
Mid-morning · fasted
  • Myo-Inositol 1 g
  • ALCAR 500 mg
  • L-Theanine 100 mg
  • ✅ Bilberry 100 mg — LIVE ⟨N⟩LE MirtoSelect 100 mg fruit, 36% = 36 mg anthocyanins/day — 11–21% of every dose where a human glycemic or antiplatelet effect was shown. Bleeding concern largely defused at this dose; so is the expected glucose effect.
  • 🔵 Agmatine Sulfate 250 mg — #2 of 4 — starts 8/7Clean, uncrowded slot.
  • 🍄 Cordyceps 500 mg — #2 of 2 · STARTED 8/24 ⟨N✓8-24⟩1,000 mg/day total. 🔴 Glucose-active AND antiplatelet-adjacent. The Kuhlman draw is still pending ~1 week out carrying fructosamine, insulin and HOMA-IR, so those endpoints will be an ON-CORDYCEPS reading. And he is ~8 weeks off a transfusion-requiring bleed at ferritin 10 with stool colour already voided as a monitor. Substitute monitors carry it: lightheadedness · fatigue · resting HR · the iron panel.
11:15 AM
Mid-morning fasted · stimulant
  • ⚕️ 🆕 Pantoprazole 40 mg DR🔴 MOVED 6:00 AM → 11:15 AM ⟨N✓9-03⟩. 🔴 THIS DRUG WAS NOT IN THIS FILE AT ALL, IN ANY REV. "Pantoprazole" appeared zero times in rev 7.61. The only PPI entry was "Omeprazole DR — discontinued, course complete," which is true and is not struck — but a different molecule has been running daily, unrecorded. Both iron sweeps (8/17, 8/26) ran against a schedule missing it.
    Stated by Nate 9/3: 40 mg TBEC once daily, 6:00 AM slot; stopped ~3 weeks mid-August, restarted after discomfort that restarting resolved. Prescriber: Wancata ⟨N✓9-03⟩.
    🔴 Why the clock moved and the dose did not: PPIs bind only actively secreting pumps, and eating activates them. First meal is noon, so a 6:00 AM dose was followed by six hours of fasting. Pre-meal dosing left gastric pH <4 for 17.2% of the day vs 42.0% when no meal followed (p=0.01) ⟨secondary source ⟨?⟩⟩. ⚖ Calibrated both ways: the FDA label says DR tablets may be taken without regard to meals — food delays Tmax ~2 h, Cmax and AUC unchanged. The pharmacodynamic argument carries this, not a PK one.
    🔴 CORRECTED 9-04 — "it clears the iron slot by 5 h 15 min" measured the wrong variable. That is plasma separation; what governs non-heme iron is pump inhibition, which is ~24 h and indifferent to the clock. The 6:00 AM iron previously sat 24 h after the prior dose (maximum acid recovery) and now sits 18 h 45 m after it — slightly more residual suppression, not less. Small, unquantified, and not a reason to move the PPI back: the meal-timing gain is far larger. 41 of 43 PPI patients with unexplained iron deficiency were unresponsive to oral iron; 95% responded to IV ⟨Boxer, eJHaem 2020 — abstract ⟨?⟩⟩, with hepcidin upregulation via AhR beyond the pH effect. ⚖ Counter-evidence stated: one series found PPI users repleted slightly better, and a 16-study review could pool nothing. Direction one-way, magnitude unquantified.
    📞 Portal message sent to Wancata 9/3 — indication, taper, whether the discomfort needs evaluation, and the timing change stated as made. The dose and the continuation decision are hers; the clock is not. Open item 91.
    ⚠ Named not acted on: the "faster onset, not more drug" Adderall × PPI effect now lands on XR-2 in this slot rather than XR-1 at 6:30 AM.
  • Mastic Gum 500 mg — 1 capsule✅ SWAP DONE — AND IT IS NUTRICOLOGY, NOT GRECO GUM ⟨N✓8-24 · label read⟩. NutriCology · Mastic Gum · Authentic Chios Mastiha, 240 veg caps. ✅ 2 caps = 1 g Pistacia lentiscus var. Chia resin → 500 mg/cap → 1,000 mg/day, Δ=0. ✅ var. Chia CONFIRMED — open item 41 closes on it. ✅ No oat fiber, no dicalcium phosphate → calcium 0 holds on a read list. ❌ "Filler-free" is STRUCK — HPMC, MCC, magnesium stearate, silicon dioxide (Mg contribution ~0.1–0.4 mg/day, negligible). ⚠️ No allergen-exclusion statement — "Hypoallergenic" is a claim, not a list; unverified gap on all three avoidances, no known exposure. See open item 73. ordered 8/11, not yet in hand. Pure Chios mastiha (Pistacia lentiscus var. Chia), 500 mg/veg cap, no fillers.
    ✅ Dose, count and slot unchanged: 500 mg × 2/day = 1,000 mg, one capsule per slot in either product. Same compound, same dose — no schedule change and no attribution window.
    🔴 California Gold Nutrition until the Greco bottle arrives. Contains oat fiber — not a violation (symptom-based avoidance, not celiac) but a real twice-daily exposure, and the label does not claim certified-gluten-free oats. Its label also states only Pistacia lentiscus — no Chios, no PDO; every clinical trial used Chios mastic.
    📌 The ~38 mg/day elemental Ca goes to zero on the swap. CGN carries ~19 mg/cap from dicalcium phosphate; Greco is filler-free. Only calcium source in the regimen, in no total, ~4% of a 1,000 mg RDA — and it was on board for the 8/7 serum Ca.
    🧪 Live indication is cardiometabolic ⟨N 8-11⟩, not the retired post-ERCP / ulcer / H. pylori set — see mastic-indication.
  • ⚕️ 🆕 Adderall XR-2 and its paired L-Theanine have RETURNED to this slot ← 11:55 AM ⟨N 9-01⟩This reverses the 8/26 move and restores the placement that ran 8/15–8/26. xr2-slot-history gains a fourth entry. Adderall 70 mg/day Δ = 0 — this is a clock change, not a dose change.
  • ⚕️ Adderall XR-2 30 mg🔴 MOVED 11:55 → 11:15 ⟨N 9-01⟩ · 💧 FASTED AGAIN. 🔴 Adderall XR is TWO pulses, not one — a 50:50 mix of immediate- and delayed-release beads, the DR half releasing ~4 h after dosing (XR 20 mg QD was shown bioequivalent to IR 10 mg BID at a 4-hour interval). The label's single Tmax is their midpoint. Decomposed, the fed 11:55 placement peaked ~5:25 PM and ~9:25 PM — so 15 mg, 21% of the day's dose, was peaking at melatonin time, and nothing actually peaked at the "7:40 PM" this file carried. At 11:15 fasted the pulses peak ~2:15 PM and ~6:15 PM — the evening pulse moves 3 h 10 m earlier. ⚖ Cost, stated: XR-1's DR pulse peaks 1:30 PM and XR-2's IR pulse now peaks 2:15 PM — 45 min apart, re-creating the overlap the 5/28 move existed to smooth. That is accepted deliberately: the 2026 complaint is dips, not overload, and two pulses 45 min apart read as a ~30 mg plateau across 1:00–3:00 PM, which is the window Nate names. 📞 Tell Murage — a timing change, not an approval gate.
  • L-Theanine 200 mg — 🆕 moved with it ⟨N 9-01⟩Stimulant-paired. And 11:15 is the better slot on its own merits: at 11:55 it sat 5 min ahead of a front-loaded-protein meal, and theanine is a LAT1 substrate — that meal's large neutral amino acids are its one real competitor. Fasted removes them.
11:45 AM
Pre-meal
  • 🆕 DAO Enzyme has LEFT this slot → 11:55 AM ⟨N 8-29⟩🔴 The −15 min rationale that sat here argued for −5 and concluded −15 — struck as a candidate ⟨C⟩ artifact, see dao-gastric-lead-time. ✅ Taurine does NOT follow it — see dao-slotmate-decoupling.
  • Taurine 750 mg powder · or 1,000 mg cap (2 × 500) — 🆕 pre-Meal 1 ⟨N 8-10⟩🆕 Redistributed ⟨N 8-10⟩ — six slots → five, three of them pre-meal. Day total is now 4,000 ⟨N 8-12⟩ (the 8:45 PM dose was restored 500 → 1,000); the 8-10 redistribution itself was total-neutral at 3,500. Taurine is glucose-dependent insulinotropic via TauT in β-cells, so it is dosed ~30 min ahead of the excursion rather than with it (Tmax ~1.5 h).
11:55 AM
5 min pre-meal · stimulant
  • 🧫 DAO Enzyme 1 cap · #1 of 4 — 🆕 MOVED 11:45 → 11:55 ⟨N 8-29⟩Seeking Health DAOgest® 4.2 mg, 30,000 HDU ⟨N✓8-15⟩. ⏱ ≈5 min before Meal 1; ≈2 min before the first bite is the target. Small sip of water, then start eating. Free of egg, fish, gluten, GMO, milk, peanut, shellfish, soy, tree nut, wheat — the only recent product naming all three avoidances.
  • 🔴 🆕 ADDERALL XR-2 AND ITS PAIRED L-THEANINE HAVE LEFT THIS SLOT → 11:15 AM ⟨N 9-01⟩This slot is now the DAO capsule only. Derivation lives at the 11:15 AM slot and is not duplicated here. ✅ The DAO capsule does NOT follow them and does not move — its placement is pinned to the meal, not the stimulant; the two were only ever co-timed incidentally, which dao-gastric-lead-time established when the −15 min "ceiling" argument was struck.

🔴 SUPERSEDED IN FACT 9-01 — the historical claim below stands as written and the geometry moved. XR-2 returned to 11:15 AM fasted ⟨N 9-01⟩, so the fed-state arithmetic in this block describes a placement no longer running. Kept because it is the derivation the 9/1 two-pulse decomposition corrects. Its "~7:40 PM peak" is a midpoint between two bead pulses, not a peak.

🔴 ABSORPTION CHECK RUN AND SHOWN — THE CONSEQUENCE IS LARGER THAN THE 40 MINUTES ON THE CLOCK ⟨C·8-26⟩. Five minutes ahead of the biggest meal of the day, taken with the first fatty bites, is functionally a fed dose.

Adderall XR's own label, at the 30 mg dose: "Food does not affect the extent of absorption … but prolongs Tmax by 2.5 hours (from 5.2 hrs fasted to 7.7 hrs after a high-fat meal)" for d-amphetamine ⟨FDA label, NDA 21-303 — read directly⟩.

📐 Former 11:15 fasted → d-amph peak ~4:25 PM. New 11:55 fed → peak ~7:40 PM. A ~3 h 15 m shift, not 40 minutes. XR-1 → XR-2 peak gap goes 4 h 45 m → 7 h 55 m.

✅ Calibrating the other way, and it matters: the 5/28 → 8/15 placement at 11:45 was also 15 min pre-meal and therefore also fed. He ran a fed XR-2 for roughly two and a half months. The 8/15 move to 11:15 was the anomaly. This is a restoration of a known state, not an experiment.

⚠ Watch: a peak near 7:40 PM sits against gabapentin at 8:45 PM, melatonin at 9:30 PM and sleep onset. If sleep latency changes, this is the first suspect — see open item 76. ✅ AUC and Cmax unchanged — a Tmax shift, not a dose change. 📞 Tell the prescriber: information, not an approval gate.

12:00 PM
Meal 1 — biggest, front-load protein
🥑 Fat-anchored — with the first fatty bites
  • Creon 1 + 2 caps
  • Digestive Enzymes Ultra 1 cap
  • 🔴 TAU (Triacetyluridine) 40 mg ⟨?⟩ — #1 of 2 — 🆕 MOVED FROM 3:00 PM ⟨N 8-26⟩⚠ Not taurine.
    ⏱ WHY THIS SLOT — the spacing is the whole point. The two doses sat 3 h 30 m apart (3:00 + 6:30 PM), then 20 h 30 m of nothing. 12:00 PM + 8:00 PM is exactly 8 h — the interval the only human PK study actually dosed ⟨Weinberg, PLoS ONE 2011;6(2):e14709, PMID 21379380 — full text read, Methods + Tables⟩.
    📐 THE FINDING: after six days of q8h dosing, baseline-adjusted AUC was identical to Day 1 (599.5 vs 606.2 µM·h, NS) — but the trough rose 4.7 → 31.1 µM, a 6.6× floor elevation (p<0.0001). Repeated dosing does not stack peaks; it lifts the floor, and only even spacing does it. t½ lengthens 3.4 → 5.3 h on repeated dosing (p=0.01). Tmax 1.3 h.
    ✅ Best absorption slot in the day for it: TAU's 4.2× advantage over pure uridine (Cmax 150.9 vs 36.1 µM) exists because it is lipophilic and absorbed by passive diffusion — no pyrimidine transporter needed. This is the fattiest meal.
    🔴 CORRECTS A rev 7.55 ERROR, stated not hidden: 7.55 filed TAU under "water-soluble" at both meals because the divide was rebuilt before this pharmacology was checked. Same error class as the Quercetin Phytosome and PEA misfilings that rev fixed.
    🔴 DOSE STILL UNRESOLVED — open items 75 and 75b. ND's page reads 25 mg/capsule; this file says 40 mg. Read the bottle. And at either figure the dose is 131–210× below the studied exposure — see 75b.
    ❌ Not temporary — no reversal block. 🔴 It shares the 8:00 PM slot with the EGCG relocation (open item 79, reverts on iron's exit). TAU does NOT ride that trigger.
  • Omega-3 (Ultimate Omega)
  • D3 5,000 IU + K2
  • Urolithin A 500 mg — fattiest bite
  • Curcumin (Nanocur) 500 mg
  • Boswellia 350 mg — Casperome® Boswellia Phytosome®ND · B. serrata resin, 25% triterpenoic acids, 1 cap. Carrier is sunflower lecithin — the soy gate does not engage here. Label lot BSPCS2042926. ⟨N✓8-11 · label-verified⟩
  • Holy Basil Force #2 of 3 — supercritical CO₂ in EVOO
  • Astaxanthin 12 mgCalifornia Gold Nutrition — AstaLif®, pure Icelandic astaxanthin. ⟨N 8-11⟩
  • 🩸 EGCG has LEFT this slot → 8:00 PM dessert ⟨N 8-26⟩Meal 1 is the biggest and most iron-dense meal; dessert is the lightest. See the dessert slot for the full derivation and open items 77–79.
  • Ubiquinol 100 mg
  • SerinAid PS 200 mgSoy-lecithin — lipid fraction, no trypsin inhibitors. Since rev 7.25 this is the general case, not an exception.
  • Milk Thistle 1 softgelLife Extension — Advanced Milk Thistle. ⟨? — brand ⟨N 8-11⟩; the SILIPHOS® 80 mg figure is from a 3/7/2026 session listing, not a label read⟩
  • 🆕 Quercetin Phytosome — 1 capsule —MOVED UP FROM WATER-SOLUBLE ⟨N 8-26⟩ND — Quercefit® (Indena), Sophora japonica, 250 mg ≈ ~100 mg actual quercetin. 🔴 A phytosome IS a phospholipid complex — the same delivery technology as the Casperome Boswellia and Siliphos Milk Thistle already in this group, and it was on the opposite side of the divide from both. See quercetin-dose-and-unit.
    🔴 Unit correction ⟨C-origin 2-27-2026⟩: a prior session recorded 400 mg/day by counting the whole complex as active — Quercefit is ~40% quercetin. Same class as the agmatine 43% gap and the NAC molar trap at 26%. ✅ HOLD at 1 cap. Do not raise. Quercetin ≥500 mg/day → diastolic −2.98 mmHg; <500 mg/day → −0.24, null ⟨Serban 2016 JAHA n=587; Huang 2020 n=896⟩. Grape Seed was cut at −2.80 against a floor of 57. ⚠ On an exposure basis the ~20× formulation may already sit in the ≥500 band — the mass number reads low and that reading is not safe to act on. ⛔ Mast-cell stabilization runs at 100 µM; achievable plasma is low single-digit µM — likely unreachable. The same exposure problem that cut resveratrol, and the one now recorded against EGCG at open item 78.
  • 🆕 PEA 400 mg —MOVED UP ⟨N 8-26⟩Palmitoylethanolamide is a fatty-acid amide — lipophilic, poorly water-soluble. It was misfiled at both Meal 1 and dinner.
  • 🍄 Erinamax 500 mg✅ Permanent home ⟨N 8-11⟩ — the Meal 2 / Dinner alternative is retired. Erinacine-A 2.5 mg/cap label floor; dose unknown within 2× pending ND's spec answer — see the follow-up list.
💧 Water-soluble — once you’ve eaten
  • ✅ ProBiota HistaminX 1 cap — STARTED 7/21Alone, single-variable, landed ≥1 week after the acid environment settled. Attribution window 7/21 → ~8/4 — this is the live trial. Nothing else new enters Meal 1 until it closes, which is a second independent reason the Erinamax dose step waits for post-8/1.
  • Glycine 1.5 g
  • L-Glutamine 5 g
  • 🆕 Sodium Chloride — #2 of 4 —MOVED DOWN ⟨N 8-26⟩A water-soluble salt with no fat requirement; it was heading the fat-anchored list.
  • OptiMSM 1,500 mg — #1 of 2
  • NAC 1,000 mg — Nootropics Depot, pure — 🆕 12:30 PM DOSE FOLDED IN HERE ⟨N 8-26⟩#1 of 3. Stated reason: with food, to minimise GI upset. ✅ Daytime NAC UNCHANGED at 2,000 mg — 500×4 across four slots becomes 1,000 + 500 + 500 across three. No total moves. 🆕 Day total 3,800 ⟨N 8-11⟩ · 48.4 mg/kg · 69% of the ~70 mg/kg anchor · 106% of Lizzo's high arm. Ramp complete.
  • TMG 500 mg
  • Benfotiamine 300 mg
  • PQQ 20 mgLife Extension — PQQ disodium salt, generic. ✅ Dose basis RESOLVED 8/11: the trials, the EFSA authorisation and this label all express the dose as mg of the disodium salt — your 20 mg is the trial 20 mg. The 17.65 mg free-acid figure was correct but moot. Residual is QC, not chemistry: BioPQQ™ carries a named organism and ≥99.0% purity; generic does not.
  • Ergothioneine 30 mgToniiq — MitoPrime®, 98% L-ergothioneine, fermentation-derived. ⟨N 8-11⟩
  • Cognance 100 mg
  • Spermidine 3 mg — 1 mg/cap × 3California Gold Nutrition, from 100 mg rice germ extract (Oryza sativa) — not wheat, so the gluten avoidance does not engage. Tapioca-dextrin formulation; no MIRICELL™ on this lot ⟨label-verified 8-11⟩.
    ⚠ dao-substrate-competition — shared polyamine transporter with agmatine, which brackets this slot at 10 AM and 1:45 PM.
  • Avmacol (sulforaphane) 480 mg
  • Myo-Inositol 500 mg
  • ✅ 🍄 Turkey Tail 500 mg — #1 of 2 · LIVE ~8/11 ⟨N 8-11⟩ND powder or Real Mushrooms capsule — same dose either form. 1,000 mg/day, Meal 1 + Dinner — the pre-surgery placement, restored.
    ⚠ Pigment darkens stool cosmetically: stool colour is no longer a usable rebleed monitor. Substitutes: lightheadedness · unusual fatigue · resting HR trend · the iron panel.
12:30 PM
Cognitive
  • Magtein 667 mg — #2 of 3Cap or powder — same dose either form.
  • Cognizin 250 mg
  • L-Theanine 100 mg — 🆕 new slot ⟨N⟩🆕 Now ~75 min after the 11:15 AM XR-2 ⟨9-01⟩, not ~35 min after an 11:55 one. Midday anchors run 11:15 → 12:30 → 1:45, gaps of 75/75 min. Its function changes from post-dose to mid-interval and it does not move.
  • 🔵 NAC has LEFT this slot — folded into Meal 1 ⟨N 8-26⟩Stated reason: with food, to minimise GI upset. ✅ Daytime NAC UNCHANGED at 2,000 mg — 500×4 across four slots becomes 1,000 + 500 + 500 across three. No total moves.
    ✅ And one open question closes by removal, not by answer: rev 7.38 flagged the NAC ↔ Magtein pairing here as "new and worth one look." The pairing no longer exists — moot, not resolved.
1:30 PM
Blood pressure postprandial
  • 1 seated reading, 90 min after Meal 1 — through 7/30
  • Evening still runs lower in diastolic than midday🆕 Re-confirmed 8/11 on 64 readings (7/13–8/10): every sub-60 diastolic in the export is an evening reading; mornings never break 60. The old “falls to 115/50” line referred to 7/6 — that is now 5 weeks old and is the last sub-55 event on record.
  • ⚠ Stop rule — OR, not AND: below 100 systolic or below 55 diastolic → hold at 40 mg
1:45 PM
Between · ⚕ 🆕 Rx moved in ⟨N 8-30⟩
  • ⚕ Adderall IR-2 5 mg — 🆕 MOVED 4:00 PM → 1:45 PM ⟨N 8-30⟩🔵 A consequence of the 8/26 XR-2 move, not a new idea. The 4:00 PM slot was correct while XR-2 sat at 11:15 AM fasted → d-amph peak ~4:25 PM — the IR covered that decline. XR-2 is now 11:55 AM FED → peak ~7:40 PM ⟨ADDERALL XR® label, NDA 21-303 — read⟩, so a 4:00 PM IR (Tmax ~3 h → peak ~7:00 PM) had begun co-peaking into the evening against gabapentin 8:45, melatonin 9:30 and sleep. ✅ At 1:45 PM the IR peaks ~4:45 PM — the two peaks de-stack by ~2 h 55 m and 5 mg of amphetamine leaves the evening. 🔵 1:45 over 2:00/2:30 is a STRUCTURAL choice — existing anchor, theanine consolidates, taurine keeps a 60-min gap to the 2:45 dose; 15 min against a ~3 h Tmax is noise. 📞 Tell Murage — timing, not approval. Dose and 70 mg/day untouched. See ir2-slot-history.
  • L-Theanine 200 mg — 🔴 🆕 THE 8/30 CONSOLIDATION TO 400 mg IS REVERSED ⟨N 9-01⟩200 stays here; 200 returns to 4:00 PM. Day total unchanged at 1,500; dose count 9 → 10. Open item 84 CLOSES. 📐 The defect was in the intervals and no check looked at them: theanine's elimination t½ is ~65 min (Tmax ~48 min), so a 400 mg dose here peaks ~2:35 PM and is spent by ~4:30 — the consolidation replaced two even 2 h 15 m gaps with one 4 h 30 m gap, the largest daytime interval in the schedule by more than double. ❌ The efficiency argument was looked for and does not exist: plasma AUC rises dose-dependently across 50/100/200 mg and no human PK at 400 mg was located. The case is coverage, and only coverage.
  • 🆕 Taurine 500 mg — MOVED FROM 4:00 PM ⟨N 8-30⟩Its indication is IR-pairing, so it follows the IR. Tmax ~1.5 h → peaks ~3:15 PM, riding the IR's ascent toward its ~4:45 PM peak — same relationship it had at 4:00 PM, 2 h 15 m earlier. ✅ PAT1 checked, and the "cleanest slot" property SURVIVES: this slot carries no PAT1 substrate — ALCAR is OCTN2, agmatine is a polyamine, theanine is LAT1. Nearest glycine is 1 g at Meal 2, 75 min behind. ⚠ One new proximity: taurine against itself, 500 here and 750 at 2:45 — Tmax flattening, not AUC loss, and a flatter curve suits the glucose leg. Day total unchanged at 4,500.
  • 🔵 Agmatine Sulfate 250 mg — #3 of 4 — starts 8/7~1 h 45 m past Meal 1 → clear of the Meal 1 spermidine.
  • ALCAR 500 mgAfternoon spacing 4 h / 3¾ h / 3¼ h. Total 2,500 mg/day. Why four doses has never been written down — alcar-split-rationale ⟨?⟩.
  • Lemon Balm 300 mg (PRN)Vitacost — Cyracos® ⟨N 8-11⟩
2:00 PM
Optional
  • ☕ 🆕 Coffee — decaf + 1 shot caffeinated — OPTIONAL ⟨N 8-26⟩≈65–80 mg caffeine (a single espresso shot runs ~63–75 mg; decaf adds ~2–5 mg).
    ✅ 2:00 PM is the one timing that was actually tested. Morck measured three positions against the same meal: coffee with the meal cut non-heme iron absorption 39% (8.12% → 4.58%); coffee 1 h after was worse (→2.25%); coffee 1 h BEFORE produced a decrease that was NOT statistically significant ⟨PMID 6402915 — results read ⟨?⟩⟩. 2:00 PM is exactly 1 h before Meal 2 — the non-inhibitory position. ⚠ Population was iron-replete; the relative timing should transfer, the absolute numbers will not.
    ⚠ RLS and caffeine — raised once, honestly, not as a gate. The clinical convention is to limit afternoon caffeine in RLS, but the primary literature is thin: one low-tier case report plus a cross-sectional study in medical students aged 18–30 that actually found higher caffeine associated with lower reported RLS intensity while worsening sleep — and poor sleep then worsened RLS. The better-supported pathway is indirect: caffeine → sleep disruption → RLS. Per brief item 9, the burden sits with the claim.
    📐 t½ ~5 h → ~25–30 mg still on board at the 9:30 PM melatonin. ⚠ Lands in the same window as the XR-2 Tmax shift — open item 76, not separable.
    ✅ BP: the 1:30 PM reading is 30 min before this drink and the 8:00 PM reading is 6 h after — neither is inside the acute caffeine window.
    🔴 THE ADDERALL-IR SENTENCE HERE IS STRUCK ⟨C·8-30⟩ — the premise is unsupported and the mechanism was in the wrong compartment. It read: "the 4:00 PM IR is 2 h downstream … 2 h is adequate separation." ❌ Coffee is not on Adderall's label acidifier list (that names glutamic acid HCl, ascorbic acid, ammonium chloride, sodium acid phosphate) ⟨NDA 011522 — read⟩, and the source cited for it calls the effect understudied, significance unknown ⟨Carlat 2018 ⟨?⟩⟩. 🔵 The real pH effect is RENAL, not gastric, and it is large: t½ 7–14 h in acidic urine vs 18–34 h in alkaline, ~7 h per pH unit ⟨Änggård 1973 — ⚠ amphetamine-psychosis patients, high dose; mechanism transfers, numbers do not⟩. 🔴 And beverage pH does not predict urine pH — orange juice at pH 3.64 produced ALKALINE urine ⟨PMID 3940208 ⟨?⟩; coffee untested⟩. ⚖ Calibrated both ways: this equally removes any reason to keep the IR away from this slot. ✅ The live interaction is pharmacodynamic — caffeine and IR curves overlap the same whether the drink is 15 min before or after, so ordering cannot fix it. 🔵 This slot stays at 2:00 PM because IRON pins it (Morck), not Adderall. The IR is now 15 min upstream, deliberately and costlessly. See coffee-ir-acidity-premise.
2:45 PM
Pre-meal
  • 🆕 DAO Enzyme has LEFT this slot → 2:55 PM ⟨N 8-29⟩✅ Taurine stays — dao-slotmate-decoupling.
  • Taurine 750 mg powder · or 500 mg cap — 🆕 pre-Meal 2 ⟨N 8-10⟩
2:55 PM
5 min pre-meal
  • 🧫 DAO Enzyme 1 cap · #2 of 4 — 🆕 NEW SLOT ⟨N 8-29⟩DAOgest® 4.2 mg, 30,000 HDU. ⏱ ≈5 min before Meal 2; ≈2 min before the first bite is the target.
3:00 PM
Meal 2 — folded
🥑 Fat-anchored — with the first fatty bites 🆕 DIVIDE ADDED — THIS SLOT HAD NONE ⟨N 8-26⟩
  • Creon 2–3 caps
  • Digestive Enzymes Ultra 1 cap
  • Longvida (curcumin) 200 mgLipid-encapsulated — unambiguously fat-dependent. Completes the 1,200 mg/day.
  • D3 extra 2,000 IUFat-soluble vitamin.
💧 Water-soluble — once you've eaten
  • Glycine 1 g
  • Ester-C 500 mg — collagen cofactor
  • NAC 500 mg — Nootropics Depot, pure — #2 of 3Added ~7/31 ⟨N⟩. Renumbered 8/26 when the 12:30 dose folded into Meal 1 — the dose itself did not move.
  • ⏱ 🆕 TAU has LEFT this slot → 12:00 PM Meal 1 ⟨N 8-26⟩Spacing, not dose. See the Meal 1 slot for the PK derivation.
  • Myo-Inositol 500 mg
  • Avmacol 480 mg
  • 🍄 Lion’s Mane 500 mg (#2)Real Mushrooms, beta-(1,3)(1,6)-glucan standardized (~300 mg). Water-soluble polysaccharide — no fat dependency, so placement is already right and does not move.
4:00 PM
Afternoon
  • 🔴 ADDERALL IR-2 AND TAURINE 500 LEFT THIS SLOT → 1:45 PM ⟨N 8-30⟩Derivation lives at the 1:45 PM slot. 🆕 L-Theanine 200 returned here 9/1 ⟨N 9-01⟩ — the IR and the taurine did not.
  • ⚕ GABAPENTIN 600 mg — #1 of 2 — 🆕 ⟨N 8-15⟩⏱ 2–3 h ahead of ~7 PM symptom onset (Tmax 2–3 h). 🔴 Timing is NOT as prescribed — the dose is. Prescriber said "afternoon and evening"; both doses moved later on chronobiology, stimulant-collision and magnesium grounds. Absorption is saturable via LAT1 — ~60% BA at 300 mg, ~40% at 600, ~35% at 1600 — so the split is right and the two doses sit 4 h 45 m apart. 3 h 30 m clear of the 12:30 PM Magtein. See gabapentin-timing-rederivation.
  • L-Theanine 200 mg — 🆕 RESTORED HERE ← 1:45 PM ⟨N 9-01⟩Reverses the 8/30 consolidation; derivation at the 1:45 PM slot. ✅ The Adderall IR and Taurine 500 do NOT come back — only the theanine. Why 4:00 and not 5:00: against the post-move peaks (1:30 · 2:15 · 4:45 · 6:15 PM) a 4:00 dose peaks ~4:50 and runs to ~6:15 where the existing 100 mg takes over — continuous cover; 5:00 peaks ~5:50 and leaves 4:00–5:20 bare. ⚖ Cost, stated: rev 7.59 recorded that losing the theanine helped gabapentin here. Settled on this file's own arithmetic — 1.148 mmol theanine vs 3.504 mmol gabapentin = 32.8 mol% against dietary protein delivering tens of mmol and still raising gabapentin AUC +14%. ⚠ On gabapentin's exit this slot now SHRINKS, it does not disappear — the rev 7.59 "delete the slot" instruction is struck.
5:00 PM
Between
  • Sodium Chloride — #3 of 4
  • ALCAR 500 mg
  • 🔵 Agmatine Sulfate 250 mg — #4 of 4 — starts 8/7Last one of the day — well clear of the 8:30 PM fast. Nothing lands at noon (spermidine) and nothing after 5 PM.
6:00 PM
Pre-dinner
  • Mastic Gum 500 mg — 1 capsule✅ NUTRICOLOGY MASTIC GUM — LIVE 8/24 ⟨N✓8-24 · label read⟩. Not Greco Gum — open item 73. 500 mg/cap, var. Chia confirmed, no oat fiber, no calcium filler. CGN contains oat fiber — see the 11:15 AM slot and Standing constraints.
6:15 PM
Pre-dinner
  • L-Theanine 100 mg
  • ⏸ Berberine Phytosome 275 mg — HELD 7/10 (#1 of 2)BP/anemia gates, not hypoglycemia. ≥72 h from any telmisartan change.
  • 🆕 DAO Enzyme has LEFT this slot → 6:25 PM ⟨N 8-29⟩✅ L-Theanine and Taurine both stay — dao-slotmate-decoupling. 📌 The 8/15 “6:25 merged into 6:15” note is now historical: a 6:25 slot exists again but holds only the capsule.
  • Taurine 750 mg powder · or 500 mg cap — 🆕 pre-dinner ⟨N 8-10⟩⚠ This is the one that lands in the evening hypotensive window (dinner-hypotensive-load, −8.3 mmHg diastolic, measured). Kept because the glycemic indication is meal-linked and the eating window is the evening — a real trade, not an oversight.
6:25 PM
5 min pre-dinner
  • 🧫 DAO Enzyme 1 cap · #3 of 4 — 🆕 NEW SLOT ⟨N 8-29⟩DAOgest® 4.2 mg, 30,000 HDU. ⏱ ≈5 min before dinner; ≈2 min before the first bite is the target.
6:30 PM
Dinner
🥑 Fat-anchored
  • Creon 1 + 1 caps
  • Digestive Enzymes Ultra 1 cap
  • Curcumin (Nanocur) 500 mg
  • Boswellia 350 mg — Casperome® Boswellia Phytosome®ND · sunflower-lecithin carrier. ⟨N✓8-11 · label-verified⟩
  • Resveratrol blend — 🚫 CUT DECIDED ⟨N 8-15⟩ · ⏳ EXECUTES AFTER THE ~8/21 DRAW✅ ⟨?⟩ CLOSED — label read 8/15: trans-resveratrol 250 · quercetin 150 · grape + wild blueberry 85 · fisetin 10. ⏳ Not today: 11 tests overlap the two orders and form a paired series — subtracting a compound 6 days out breaks it. Sequencing, not doubt. ⚠ Three riders leave with it: quercetin −150 · fisetin −10 · grape+blueberry −85. 🔴 That grape is grape FRUIT, not the grape SEED cut 8/11 — grapeseed-cut is unaffected. Grounds are the unworthy limb of burden-of-proof: SIRT1 mechanism falsified, null in T2D meta-analyses, and the one phenotype-matched mechanism misses on exposure by 40–600×. See resveratrol-cut.
  • Vitamin E 200 IU — NOWLow-dose cap held deliberately: weak vitamin-K antagonism, no tocotrienol megadose.
  • 🔵 SPM Pro-Resolve 1 softgel — ~8/1
  • Zinc / Copper 15 / 1 mgAnastomotic healing. Copper is the DAO metal cofactor — 15:1 sits AT the 8–15:1 edge, not past it. Serum Cu + ceruloplasmin added to the 8/1 draw.
  • Ubiquinol 100 mg
  • SerinAid PS 100 mg
  • Holy Basil Force #3 of 3 — EVOO base, meal-anchored
  • 🆕 Urolithin A 500 mg —MOVED UP ⟨N 8-26⟩🔴 INTERNAL CONTRADICTION RESOLVED. It was fat-anchored at Meal 1 and water-soluble here — the same compound at the same dose on opposite sides of the same divide. Whichever was right, both could not be. Resolved to fat-anchored at both meals.
  • 🆕 PEA 400 mg —MOVED UP ⟨N 8-26⟩Fatty-acid amide; misfiled here and at Meal 1.
💧 Water-soluble — once you've eaten
  • ✅ MegaSporeBiotic 1 cap — STARTED 8/5 ⟨N⟩1 cap with dinner. ✅ Label-correct and no change recommended — Microbiome Labs directs 1 cap with food, stepping to 2/day at week 3. Spore-based Bacillus survives gastric acid and bile by design, so Creon is not a concern, and dinner keeps it well clear of the Meal 1 ProBiota. ⚠ Do not step to 2 caps during the NAC/Turkey Tail window — its listed side effects (cramping, loose stools) are the exact signal those are being read on. Earliest sensible step is after the 8/14 NAC watch closes.
  • Glycine 1.5 g
  • L-Glutamine 5 gThe live mucosal-integrity agent — and the real DAO lever.
  • ⏱ 🆕 TAU has LEFT this slot → 8:00 PM dessert ⟨N 8-26⟩Both doses moved; the pair is now exactly 8 h apart where it was 3 h 30 m. See Meal 1.
  • OptiMSM 1,500 mg — #2 of 2
  • NAC 500 mg — Nootropics Depot, pure — #3 of 3Renumbered 8/26 when the 12:30 dose folded into Meal 1 — the dose did not move.
  • TMG 500 mg
  • ✅ 🍄 Turkey Tail 500 mg — #2 of 2 · LIVE ~8/11 ⟨N 8-11⟩Second of two. Pre-surgery placement restored.
  • ⏸ Berberine 275 mg — HELD 7/10 (#2 of 2)
7:00 PM
Evening
  • Magtein 667 mg — #3 of 3Cap or powder — same dose either form.
  • L-Theanine 100 mg — 🆕 new slot ⟨N⟩🆕 ⚠ SUPERSEDED IN FACT 8-30 — the historical claim stands; the geometry moved. IR-2 relocated to 1:45 PM, so this no longer bridges an IR. It now sits between the ~4:45 PM IR peak and the ~7:40 PM XR-2 peak — arguably a better use of it, but that is a new rationale ⟨C·8-30⟩, not an inherited one.
  • ⚠ MagteinMOVED OUT of this slot to the 6:30 PM dinner ⟨N 8-15⟩Gabapentin-driven. Reverts to 7:00 PM on gabapentin exit — see the restore block.
7:55 PM
5 min pre-dessert
  • 🧫 DAO Enzyme 1 cap · #4 of 4 — 🆕 NEW — FOURTH CAPSULE ⟨N 8-29⟩✅ Closes the dessert gap dao-per-meal-logic has named since rev 7.45. 🔴 ⚠ Do not judge this one on felt effect — the 8:00 PM slot carries NAC 1,800 mg, 47% of the day’s NAC, and acetylcysteine is a documented DAO inhibitor at >20%. See dao-nac-thiol-collision and open item 83.
7:45 PM
Pre-dessert
  • ✅ Gymnema 400 mg — RESTORED ⟨N 8-6⟩, starts 8/7Back in its original slot at its original dose. Removed 7/10 on postprandial-fall, which is falsified (paired delta +3.4 mmHg). ⚠ Glucose-active, so it holds to post-draw alongside agmatine. Confirm 400 mg against the bottle — that figure is carried from this file, not read off a label.
  • ⏸ Berberine 275 mg — HELD 7/10
8:00 PM
Blood pressure postprandial
  • Take before dessert. 1 seated reading, 90 min after dinner
  • Dinner carries the hypotensive load Meal 1 no longer doesCurcumin, resveratrol, quercetin, magnesium.
8:00 PM
Dessert — light
🥑 Fat-anchored — with the first fatty bites 🆕 DIVIDE ADDED — THIS SLOT HAD NONE ⟨N 8-26⟩
  • Creon 1 cap
  • Digestive Enzymes Ultra 1 cap
  • Milk Thistle 1 softgelLife Extension — Advanced Milk Thistle. Siliphos phospholipid complex. ⟨? — see Meal 1⟩
  • 🔴 TAU (Triacetyluridine) 40 mg ⟨?⟩ — #2 of 2 — 🆕 MOVED FROM 6:30 PM ⟨N 8-26⟩ · ⏱ exactly 8 h after dose 1⚠ Not taurine. Rationale lives at Meal 1 and is deliberately not duplicated. Short form: q8h is the interval that raised the trough 6.6×; 3 h 30 m raised nothing.
    ⚠ Honest cost: dessert is light on fat, which matters for a lipophilic prodrug. Spacing is evidenced; the fat effect is mechanism-level and unmeasured. Creon + Digestive Enzymes are still here, so lipase is present.
    🔴 Does NOT share the EGCG reversal trigger (open item 79). TAU stays here regardless.
💧 Water-soluble — once you've eaten
  • 🩸 🆕 EGCG ≤400 mg —MOVED HERE FROM MEAL 1 ⟨N 8-26⟩ — ⚠ with food, NEVER fasted🔴 The claim that prompted this does not survive. A parallel thread wrote that tea catechins are a stronger iron inhibitor than coffee and that this was "a larger iron leak than the coffee ever was." That is compound-level reasoning applied to a purified-extract dose — adversarial brief item 11.
    📐 Searched at the strength actually held: purified EGCG 150 mg → 14% relative reduction, NOT significant; 300 mg → 27% (p=0.0002) ⟨Ullmann, TEAVIGO 94% crystalline EGCG, Phytomedicine 2005;12:410–15 ⟨?⟩⟩ — against black tea at 79–94%. At ≤400 mg this is ~30–35% on ONE meal — a third to a half of what was asserted, and coffee is the stronger inhibitor per serving, not the weaker.
    ✅ The 300 mg arm ran in women with low iron, so it transfers to ferritin 10. ❌ But Ullmann's "does not impair" conclusion was scoped to normal iron stores — that phrase is not imported.
    ✅ Why dessert and not fasted: Meal 1 is "biggest, front-load protein" — the most iron-dense meal; dessert is the least. 🔴 A fasted slot was checked and rejected — fasted intake raises free-catechin bioavailability and hepatic signals cluster at ≥800 mg bolus; ≤676 mg fed or fasted showed no hepatic AEs, and 756 subjects at ≤316 mg showed no transaminase elevation ⟨EFSA 2018;16(4):5239; UK COT 2024 ⟨?⟩⟩. A fasted slot would raise Cmax for zero iron benefit — fasted slots contain no dietary iron to protect. 🛑 6:00 AM is disqualified outright: that is where the iron is.
    ⚠ ⟨?⟩ The caffeine content of this capsule is unrecorded in every rev. At noon that did not matter; at 8:00 PM it does — open item 77.
    🔴 And EGCG still has no indication anywhere in this file — open item 78.
  • ✅ NAC bolus — NOW 600 × 3 = 1,800 mg · 🆕 RAMP COMPLETE ⟨N 8-11⟩The 8/14 step landed early. Day total 3,800 · 48.4 mg/kg · 69% anchor · 106% Lizzo high arm.
    ⚠ At 3 caps: Se 75 µg · Mo 150 µg — from here and nowhere else.
    🔴 This step, the 4th daytime capsule, and Turkey Tail all landed 8/11. All three are read on the same GI signal — a symptom in the next 3–5 days is unattributable by construction.
8:45 PM
Wind-down
  • Sodium Chloride — #4 of 4Later coverage blunts the overnight Na drop.
  • Taurine 1,000 mg — 🆕 RESTORED ⟨N 8-12⟩1 g → 500 at rev 7.35 → back to 1,000 on your stated sleep-support indication. Day total → 4,000 (+500 over the established 3,500) — scope limit engaged, indication named, open item 42. The overnight-coverage half stays retired — plasma t½ 1.0 h ⟨DOC: Ghandforoush-Sattari 2010, §2 methods, n=8⟩ — and is not what restored this. ❌ Nor is the GlyR-threshold argument: raised 8/11, withdrawn 8/12 — see taurine-glyr-threshold.
  • L-Theanine 200 mg
  • Myo-Inositol 500 mg
  • ⚕ GABAPENTIN 600 mg — #2 of 2 — 🆕 ⟨N 8-15⟩🔴 This slot is why the magnesium moved. 2 h 15 m clear of the 6:30 PM Mg. Divalent cations block LAT1 absorption — MgO cuts gabapentin AUC 43% ⟨PMID 22240839⟩. ✅ Co-administered L-Theanine 200 mg is a LAT1 substrate but is only 32.8 mol% of the dose, against dietary protein at tens of mmol that still raises AUC +14%.
  • ⚠ Mg BisglycinateMOVED OUT to the 6:30 PM dinner ⟨N 8-15⟩🆕 200 mg is ELEMENTAL Mg ⟨N✓8-12⟩ — so this tablet also carries 1,235 mg glycine, which no prior rev counted. Not a dose change; an accounting one. See mg-bisglycinate-glycine.
9:30 PM
Melatonin
  • Melatonin 3 mg — ~30 min before sleep
  • 🔵 1 mg vs 3 mg resolves on rs10830963 (MTNR1B)It’s in the AncestryDNA raw file. Free, ten minutes, may prove the question moot.
9:45 PM
Pre-sleep — last action
  • Glycine 3 gSLEEP dose ⟨Yamadera 2007 · Inagawa 2006⟩ — 3 g pre-bed, PSG-confirmed. Placed for sleep; the NAC was moved to join it, not the reverse. Stays exactly here. 🆕 REVISED 8-15: the bisglycinate moved to dinner, so glycine after 8:30 PM is now 3,000 mg — 36.4% of the whole-day total. ⚠ A relocation, not a reduction — whole-day glycine is unchanged at 8,235, and this reverts on gabapentin exit.
  • Apigenin 100 mg — histamine, complements quercetinNootropics Depot. ⟨? — botanical source and purity not verified⟩
  • Lemon Balm 300 mgVitacost — Cyracos® ⟨N 8-11⟩

Daily totals · rev 7.63

Agmatine1,000 mg🔵 RESTORED ⟨N 8-6⟩, starts 8/7 post-draw. 4 × 250 mg sulfate ≈ 570 mg free base (57.0%) · 12.7 mg/kg. Reinstated on stated benefit — not on the burden rule, whose premise fails here. Dissent preserved in the registry.
Vitamin B616 mg25 mg P5P, Infini-B only. >EFSA UL (12), <US UL (100). Standalone P5P rejected 7/22.
NAC🆕 3,800 mg🆕 4 × ND 500 fed (noon · 12:30 PM · 3 PM · dinner) + NOW 600 × 3 at the 8 PM dessert · 48.4 mg/kg · 69% anchor · 106% Lizzo high arm. ✅ Ramp complete ⟨N 8-11⟩. ⚠ +500 above the 3,300 target decided 8/3 — that increment has no indication on file.
Selenium🆕 75 µg8 PM bolus only, at 3 caps. Zero from any other source. 19% of the 400 µg UL.
Molybdenum🆕 150 µg8 PM bolus only, at 3 caps. 7.5% of the 2,000 µg UL.
Glycine8,235 mg🆕 CORRECTED ⟨8-12⟩ — a measurement fix, not a dose change. Labeled 1.5 + 1 + 1.5 + 3 g = 7,000 · plus 1,235 mg obligate from Mg bisglycinate (200 mg elemental ⟨N✓8-12⟩). 104.9 mg/kg. Moves glycine from 89% → 105% of Baylor weight-scaled — a line every prior rev stated the wrong side of. Intake never moved. ⛔ Not a reason to raise NAC — see glynac-1to1-ratio. Indication ⟨N 8-12⟩: daytime doses distributed to pair with NAC timing.
Taurine4,500 mg🆕 THE 500 mgMOVED 4:00 PM → 1:45 PM WITH THE ADDERALL IR ⟨N 8-30⟩ — still six slots, Δ = 0. powder 750 + 750 + 500 + 750 + 750 + 1,000 · cap 1,000 + 1,000 + 500 + 500 + 500 + 1,000 — same total either form. 57.3 mg/kg. Meal-anchored 50.0% powder / 44.4% cap — unchanged, no meal-anchored dose moved. 🔴 Landing from 2:45 PM on RECOMPUTED: 66.7 → 55.6% powder, 55.6 → 44.4% cap (the 500 now lands before 2:45, not after). ✅ Dose CV unchanged at 19.2 / 33.3% — checked, not assumed: the multiset is identical and CV has no time term. 🆕 Intervals re-derived: 4h45 · 2h00 · 1h00 · 3h30 · 2h30 · 10h15 = 24h00 ✓ — the rev 7.35 figures were computed on 3,500 across five slots and are superseded. ⚠️ Now +1,000 over established across TWO named increments — open items 42, 71. 🆕 First safety anchor: Shao & Hathcock OSL 3,000 mg → 150%; highest RCT dose 150 mg/kg/d ≈ 11,775 mg → 38%; Galloway 7-day arm 56.8 mg/kg → 101%. No NOAEL exists — an OSL is where evidence is strong, not where harm begins. ⚠️ Taurine is vasoactive and this hub has never named it as one, against a 57 mmHg diastolic floor. It has run ≥3,500 through the whole 28-day record with no signal — monitored by the 8:00 PM reading, not a reason to hold. 51.0 mg/kg. ⚠️ +500 over the established 3,500 — this one IS an increase, so the scope limit engages. Indication named: sleep support ⟨N 8-12⟩. Reverses the 8/10 cut — yours reversing yours. Full indication ⟨N 8-10⟩: pancreas · glucose management · smoothing anxiety and Adderall.
TAU80 mg40 × 2 · ≠ Taurine
ALCAR2,500 mg1,000 + 500 + 500 + 500 · 6 AM / 10 AM / 1:45 PM / 5 PM
L-Theanine1,500 mg🆕 10 doses ⟨N 9-01⟩ — was 9. The 8/30 consolidation is reversed: 400 mg at 1:45 PM → 200 at 1:45 + 200 at 4:00. 200+100+100+200+100+200+200+100+100+200 = 1,500 ✓. Largest single dose back to 200 mg; open item 84 closes. The TOTAL has never changed — only the spacing did.
Myo-Inositol2,500 mg1,000 + 500 + 500 + 500
L-Glutamine15 g3 × 5 g · the live mucosal-integrity agent — also the real DAO lever
Magtein2,001 mg667 × 3 · cap or powder, same dose either form. Lands on the ~1.5–2 g/day trial range.
Mg elemental~345–405Magtein ~144 + Mg bisglycinate 200 · single figure now that both forms match. 🆕 ✅ CONFIRMED unchanged ⟨N✓8-12⟩ — this range already assumed the 200 mg was elemental, and it is. Had it been compound weight the bisglycinate would contribute 28 mg and this range would fall to ~173–233.
HMB (CaHMB) · Amino-9 Essentials0🚫 CUT ⟨N 8-14⟩ — temporary recovery-window adds; window formally closed by Wancata 8/12 ("well healed incision", "OK for activity and diet as tolerated", 1-year follow-up). HMB was a bundle: it carried ~1,000 IU D3 + ~360 mg Ca, and both leave with it. Amino-9 never had a totals line. ⚠ With both EAA sources gone, the weighed-protein item is no longer optional.
Curcumin1,200 mgNanocur 1 g + Longvida 200
OptiMSM3,000 mg1,500 × 2
NR300 mg6 AM fasted
Synapsa Bacopa360 mgsingle AM cap
Lion’s Mane1,000 mg500 × 2 · Real Mushrooms, fruiting body
🆕 Turkey Tail1,000 mg🆕 500 × 2 ⟨N 8-11⟩ — Meal 1 + Dinner. ND powder or Real Mushrooms cap, same dose either form. Closes the “no dose on file” gap. Carries no Se or Mo.
Mastic Gum1,000 mg500 × 2 · 1 capsule per slot ⟨N 8-11⟩. ✅ Total unchanged by the product swap — both products are 500 mg/cap. ⏳ Greco Gum ordered 8/11; CGN until it lands. 🔴 CGN carries oat fiber + ~38 mg elemental Ca/day (in no other total); Greco is filler-free, so both go to zero on arrival.
Vitamin E200 IUNOW · low-dose cap, weak vit-K antagonism
PEA800 mg400 × 2
Urolithin A1,000 mg500 × 2
Boswellia700 mg350 × 2
Citicoline (Cognizin)500 mg250 × 2
Vitamin D37,000 IU🆕 Reduced from ~8,000 ⟨N 8-14⟩ — 5,000 (Meal 1) + 2,000 (Meal 2). The ~1,000 IU HMB bundle left with the cut. ⚠ The 8/7 panel’s 25-OH-D + serum Ca were drawn with the bundle on board — an on-HMB reading.
Cordyceps1,000 mg🆕 NEW LINE — LIVE 8/24 ⟨N✓8-24 bottle read⟩. Real Mushrooms CORDYCEPS-M, C. militaris extract, 500 mg × 2 caps, one per slot (6:30 AM + 10:00 AM). 12.7 mg/kg · 8% β-glucans. ⚠️ The one-cap-per-slot split is inferred from the recorded placement, not stated — ⟨?⟩ on the split only. Glucose-active with the Kuhlman draw pending, and antiplatelet-adjacent: open items 69, 70.
Supplemental calcium0🆕 NOW ZERO ⟨N✓8-24 · label read⟩ — the mastic swap executed. HMB carried ~360 mg/day and left 8/14; CGN mastic carried ~38 mg/day via its dicalcium-phosphate filler and the NutriCology replacement carries no calcium filler (HPMC, MCC, Mg stearate, silicon dioxide). The conclusion holds on a read excipient list — the prior derivation rested on an unverified "filler-free" brand attribution and was right by luck. The 8/10 serum Ca was drawn with that ~38 mg on board and remains a with-calcium reading. ❌ rev 7.40’s “the only calcium source in the regimen” was false — see hmb-bundle.
Sodium~1,560 mg⚠ Do not raise until the mechanism is known. In SIADH this is the wrong direction.
🆕 🩸 Iron (elemental)🆕 72 mg alt-day🆕 NEW ROW — this table never carried iron ⟨9-03⟩. 4 × 18 mg elemental from NOW Ferrochel; ~36 mg/day averaged. Read the unit: 18 mg elemental from 90 mg of the chelate — never record 90 or 360. Base 36 protected; +36 increment carries its own indication and reversal.
⚕️ 🆕 Pantoprazole40 mg🆕 NEW ROW — absent from every prior rev ⟨N✓9-03⟩. Once daily, 11:15 AM (moved from 6:00 AM). Prescriber Wancata. ⏳ Continuation undecided pending her answer — open item 91.
Adderall70 mgXR 60 + IR 10 · full prescribed
Telmisartan40 mgHolds. Reassess ~8/1.
Saffron30 mgND, Crocus sativus stigma, 7.5% crocins / 1.0% safranals · 6:15 AM
Panax GS15-4200 mgND, 1 cap · 🆕 8:00 AM ⟨N✓9-03⟩ (was 6:00 AM — iron-driven, open item 93)
R-ALA (Na-R-ALA)300 mg🆕 8:00 AM fasted ⟨N✓9-03⟩ (was 6:00 AM — iron-driven, open item 93)
Bilberry100 mgLE MirtoSelect, fruit, 36% = 36 mg anthocyanins · 10:00 AM
Gymnema400 mg🔵 restored to 7:45 PM pre-dessert, starts 8/7. ⚠ Confirm the 400 mg against the bottle.
MegaSporeBiotic1 capdinner · started 8/5
L-Citrulline · Chromium · 🆕 Grape Seed0🚫 CUT. Citrulline ⟨N 8-6⟩ — real BP case. Chromium ⟨N 8-6⟩ — mechanism mismatch. 🆕 Grape Seed ⟨N 8-11⟩ — Nate's decision, and an independent BP case supports it: 2016 meta (16 trials, n=810) systolic −6.08 / diastolic −2.80, against a 2 mmHg margin. Never carried a dose, so no total changes.
Berberine · Potassium0Berberine held. ✅ 🆕 POTASSIUM VERIFIED CLEAR 8/14 ⟨N✓4⟩ — the VM chart’s KCl 801 mg/day is a stale entry; none is taken and the ARB constraint has never been breached. Chart entry still needs removing — open item 48.

DAO — what actually governs it

Ranked for this phenotype · B6 is not on the list

1. Substrate competition ⟨C·7-22 | i:in-vitro/porcine⟩ — 🔵 The agmatine arm returns 8/7. At 1 g/day it is the largest DAO-substrate load in the stack, crude molar load ≈ 50× dietary histamine. Caveat unchanged: in-vitro porcine — order-of-magnitude flag, not a measurement.

Transporter question closed 7/29 ⟨C·7-29 | DOC:Satriano-2001 · Gründemann-2003 · Winter-2011 · Ramos-Molina-2015⟩ — the Amino-9 collision is falsified. 🆕 (Amino-9 itself was CUT 8/14 ⟨N⟩ — this paragraph is historical.) Agmatine moves on the polyamine transporter (Km 2.5–44 µM) and OCT2/OCT3/MATE1, not the y⁺ cationic amino-acid system; arginine, lysine and ornithine were tested directly and do not compete. The real collision is Spermidine 3 mg at Meal 1 — shared polyamine route. 🔴 LIVE AGAIN from 8/7. This is exactly why no agmatine dose lands at noon: 6:15 AM, 10 AM, 1:45 PM and 5 PM are all clear of the Meal 1 spermidine.

2. Mucosal integrity ⟨C·7-22 | i:villus + GI-disease⟩ — DAO is made by mature villous enterocytes. Post-Frey + Forrest III ulcers + EPI is the likeliest suppressor. Intervention already live: L-Glutamine 15 g/day.

3. Copper ⟨C·7-22 | m:pending⟩ — the actual metal cofactor. Zn:Cu 15:1 is at the 8–15:1 edge. Added to the 8/1 draw. ⚠ Ceruloplasmin is acute-phase — read against CRP.

⚠ HISTORICAL ⟨8-15⟩ — NaturDAO left the regimen 8/15, replaced by Seeking Health DAO Enzyme. Retained because the reasoning still applies to any legume-DAO product: do not switch to NaturDAO Plus — it bundles P5P on the retired rationale. Legumactive is Pisum sativum + Lens culinaris (not grass pea → no β-ODAP concern), supplies catalase alongside DAO, and ~96 mg legume protein/day is ~3 orders below any Creon/trypsin-inhibitor concern.

What to expect

A principle, not a prediction

In T3c with retained C-peptide (1.4, June 2026) and ⟨assumed⟩ impaired glucagon counterregulation, a higher glucose floor with lower variance beats a lower mean with excursions you cannot feel or counter.

🔵 Gymnema is back in from 8/7 — glucose-active, so it drifts numbers down, the opposite direction to this principle. Berberine stays out. Citrulline is cut ⟨N 8-6⟩. If your numbers drift up slightly, that is still not a regression to correct.

⚠ This stands on glucagon-impairment, which is UNMEASURABLE (Garbacz 7/15). Keep it if you want it — but it is an assumption, not physiology.

Daily architecture · rev 7.63 · 2026-09-04 · one supplement per row · every total is an exact sum of the spine above