Master Regimen · v6.30 / rev 7.63 · 2026-09-04

Protocol Hub

Post-Frey recovery · 🆕 Turkey Tail live ~8/11 · NAC final step 8/14

Standing instruction
Take it
exactly as written
🆕 NAC RAMP COMPLETE — 3,800/day. Turkey Tail live, 500 × 2, Meal 1 + Dinner. Both landed ~8/11 — same-day, so this week's GI signal is unattributable. rev 7.38 · 2026-08-11.

🆕 THIS REV (7.58 → 7.59, 8/30): an afternoon-Rx rev. Adderall IR-2 moves 4:00 PM → 1:45 PM ⟨N 8-30⟩, taking its paired L-Theanine 200 (consolidating to a single 400 mg dose — total unchanged, 10 doses → 9) and the 8/24 Taurine 500 with it. 4:00 PM is now gabapentin-only and disappears entirely on gabapentin's exit. It follows the 8/26 XR-2 move: XR-2 at 11:55 AM fed peaks ~7:40 PM, so the 4:00 PM IR had begun co-peaking into the evening; at 1:45 PM the peaks de-stack by ~2 h 55 m. The 2:00 PM coffee does NOT move — its slot is pinned by iron, and the "2 h separation from the IR" premise was struck as unsupported. No dose changed; no total moved. Earlier — (7.55 → 7.56, 8/26): a schedule rev, then a TAU rev. New optional beverage slots at 9:00 AM (tea or coffee) and 2:00 PM (decaf + a shot). Adderall XR-2 + L-Theanine 200 → a new standalone 11:55 AM slot. 12:30 PM NAC folded into Meal 1 (daytime NAC unchanged at 2,000). EGCG → the 8 PM dessert — Meal 1 is the most iron-dense meal and ferritin is 10. Both TAU doses moved to 12:00 PM + 8:00 PM — exactly 8 h apart, on the PK finding that q8h raised the plasma trough 6.6× while per-dose AUC did not move. The with-Creon / after-eating divide was re-derived across all four fed slots — six misfilings corrected, including Urolithin A, which sat on opposite sides of the divide at two meals. Superseded background follows. 1,000 at noon + 500 (3 PM) + 500 (dinner) — 3 slots, not 4; the 12:30 PM capsule folded into Meal 1 ⟨N 8-26⟩ + NOW 600 × 3 at 8 PM. Turkey Tail live, Grape Seed cut, PQQ dose basis resolved — the LE email is cancelled. ⚠️ The 3,300 → 3,800 increment has no indication on file; your scope-limit rule asks for one. resumed and the 6:30 AM protein bite is cut — Creon goes PRN, the morning Rx runs fasted. NAC ramps 1,500 → 3,300 from 8/7, bolus at the 8:00 PM dessert. Open the follow-up list →

Today

Start here
Follow-up list
Everything waiting on you, in order, with the drafts already written. Nothing urgent.
Not an audit input
Archive
Revision history, derivations, prior adversarial-pass conclusions. Kept out of the protocol on purpose.
rev 7.63
Daily architecture
🆕 Opens in QUICK view — names and doses only. Tap Full for everything. The quick view is the same markup with 109 annotation elements hidden by CSS — nothing is duplicated, so it cannot drift. rev 7.53 superseded — delete it. The full time spine. Changed at rev 7.53 — presentation only: the Master Regimen now opens with a QUICK SCHEDULE — names and doses, no notes — above the full annotated schedule, which is unchanged. Zero dose, slot or total edits; projected from the annotated schedule and verified slot-by-slot (27 slots, 138 items). rev 7.52 superseded — delete it. Changed at rev 7.52 — two labels read: the mastic product is NUTRICOLOGY, not Greco Gum ⟨N✓8-24 label read⟩ — dose unchanged (2 caps = 1 g resin → 500 mg/cap → 1,000 mg/day), var. Chia CONFIRMED so open item 41 closes, oat fiber and calcium filler both absent, but "filler-free" is STRUCK (HPMC, MCC, Mg stearate, silica) · Cordyceps is C. militaris, 8% β-glucans, and 1,000 mg is the FLOOR of the studied range — the Cs-4 literature does not transfer; new cordyceps-antiplatelet entry. rev 7.51 is superseded — delete it. Changed at rev 7.51Cordyceps dose closed on a bottle read: Real Mushrooms 500 mg × 2 = 1,000 mg/day ⟨N✓8-24⟩ · DEVICES card added (Truvaga Plus). rev 7.50 is superseded — delete it. Changed at rev 7.50 — the first SCHEDULE rev since 7.46: Taurine 500 mg added at 4:00 PM ⟨N 8-24⟩ (day total 4,000 → 4,500, six slots, stated indication: smooths the 4 PM Adderall IR) · Cordyceps STARTED 8/24 ⟨N✓⟩ — Real Mushrooms CORDYCEPS-M, C. militaris, 500 mg × 2 = 1,000 mg/day, 8% β-glucans · Mastic swap LIVE — NutriCology, NOT Greco Gum ⟨N✓8-24 label read⟩, CGN retired, oat fiber gone, supplemental calcium → 0 · Truvaga Plus recorded LIVE since ~8/13 · gabapentin nighttime split DECLINED ⟨N 8-24⟩ · IV-iron route moved to Kuhlman, appointment 8/25 · the "~8/21" draw date de-anchored — it never happened. 🩸 Changed at rev 7.47IRON 36 mg elemental added (2 × 18 mg ferrous bisglycinate, alternate days, 6:00 AM fasted) on the 8/10 results: ferritin 10, iron saturation 4%, CRP 2. CRP normal means no acute-phase inflation — ferritin 10 reads at face value. Green tea / maté moved 7:00 → 8:00 AM, then → 9:00 AM ⟨N 8-26⟩ to clear the iron dose; that reverts on iron's exit, not gabapentin's. Ganzoni deficit ~1,272 mg — oral closes it in months, so the IV route CLOSED 8/27 — ordered by Kuhlman, ferric derisomaltose (Monoferric), avoiding FCM. Open items 3, 21, 40, 46 and 53 closed on results. Changed at rev 7.46⚕ GABAPENTIN 1,200 mg/day added (600 mg at 4:00 PM + 8:45 PM) for restless legs, as a bridge while iron studies are pending. Both evening magnesium doses moved to the 6:30 PM dinner to clear its LAT1 absorption window — this reverts when gabapentin exits. Adderall XR-2 moved 11:55 → 11:15 AM, and back to 11:55 at rev 7.55 ⟨N 8-26⟩. NaturDAO → Seeking Health DAO Enzyme at −15 min (11:45 · 2:45 · 6:15). Resveratrol CUT — executes after the ~8/21 draw, not today. Quercetin's first dose line (~100 mg actual, not the 400 a prior session recorded). Changed at rev 7.40Glycine corrected to 8,235 (the Mg bisglycinate's own 1,235 mg was never counted — accounting, not intake), Taurine 8:45 PM restored to 1,000 → day total 4,000, bottle check closed. Changed at rev 7.39Mastic Gum → Greco Gum (ordered 8/11, CGN until it lands), cardiometabolic indication on file, oat fiber and its ~38 mg Ca leaving with the swap. Changed at rev 7.38 — NAC to 3,800, Turkey Tail live, Grape Seed cut. Changed at rev 7.35Taurine redistributed: six slots → five, three now pre-meal, total unchanged at 3,500. Changed at rev 7.34 — Saffron, R-ALA, Panax, Bilberry and MegaSpore now live · Agmatine ×4 and Gymnema return 8/7 · L-Theanine 1,500 across 10 doses.
📟 Devices · v4.0
Truvaga Plus — tcVNS
🆕 LIVE since ~8/13 ⟨N⟩. Pre-meal 2-min Reduce Stress sessions; evening wind-down restored 8/20. Saved favourites: Morning Calm (Increase Happiness · 2 min · Gentle) and Nighttime Wind Down (Better Sleep · 2 min · Moderate). The quick reference is the photo-card view inside this page — open it, switch to photo card, screenshot. 🔴 Drop truvaga-protocol-v4-0-2026-08-20.html into this folder for the link to resolve. v2.0 and v3.0 are superseded. ⚠️ Lowers HR + BP against a 2 mmHg diastolic margin — but it predates the 8/24 changes, and the 28-day BP record predates it. A Hooga PRO300 red-light document is also tracked and is likewise not yet in this folder.
🆕 64 readings
Blood pressure
🆕 Re-read on 7/13–8/10. Diastolic floor 57 — zero stop-rule breaches; the last sub-55 was 7/6. The margin is 2 mmHg.
Instrument
CGM + glucometer
Low alerts ON. Meter validated 8/3 — Accu-Chek Guide, Hct 10–65%. Glucagon premise is UNMEASURABLE.
Gate board
What comes back, when
MegaSpore 8/5 · draw done 8/10 · Agmatine + Gymnema 8/7 · Turkey Tail ~8/11 · NAC 3,800 · Iron 8/17 · 🆕 Truvaga ~8/13 · 🆕 Taurine 4:00 PM + Cordyceps + Greco Gum — all 8/24.
Only what decides
Measurement plan
Iron · PT/INR · hyponatremia panel · copper + ceruloplasmin (new). Nothing decorative.
Scripts
Clinical facts to obtain
Exactly what only Kuhlman and Wancata can produce — with the words to use.

The DAO correction

What actually governs DAO

DAO (diamine oxidase) is the histamine-degrading enzyme. Its cofactors are copper · calcium · topaquinone (TPQ) — not B6. Ranked for this phenotype, the real levers are:

1. Substrate competition🔵 Reopens 8/7: agmatine returns at 1 g/day, the largest DAO-substrate load in the stack — and the Spermidine collision at Meal 1 goes live with it, which is why no agmatine dose lands at noon. Until then the supplemental load is zero. The premise was in-vitro/porcine and is an order-of-magnitude flag, not a measurement. · 2. Mucosal integrity — DAO is made by gut-lining cells; post-Frey + ulcers + EPI is the likely suppressor. Intervention already live: L-Glutamine 15 g/day. · 3. Copper — the actual metal cofactor, now added to the 8/1 draw.

⚠ B6 is not a DAO lever — it's upstream on histamine synthesis (histidine decarboxylase). 🆕 HISTORICAL ⟨8-15⟩ — NaturDAO left the regimen 8/15, replaced by Seeking Health DAO Enzyme (DAOgest® porcine, 30,000 HDU, bottle-confirmed). Retained because it still applies to any legume-DAO product: do not switch to NaturDAO Plus — it bundles P5P on the same retired rationale.

Standing constraints

Never

Acetaminophen — documented adverse, VM July 2026  ·  NSAIDs — ulcer / GI-bleed history  ·  Potassium supplements — on the ARB

Soy has moved out of this tier at rev 7.25 — it is now activity-gated, not categorical. See below.

Soy — activity-gated, not categorical (reworked rev 7.25)

Exclude: raw / unheated / high-TIA soy — raw soy flour, raw soybeans, unheated soy protein powders.  ·  Cleared: soy lecithin · soybean oil · fermented soy · hydrolysed soy protein / soy peptone · a declared trace from a fermentation medium. SerinAid PS and Erinamax sit here — not as exceptions, as the general case. 🆕 NaturDAO left the regimen 8/15 — see the yardstick note.

Ceiling of the effect. Kunitz and Bowman-Birk are serine-protease inhibitors — trypsin and chymotrypsin only. Not lipase. Not amylase. Creon is dosed in USP lipase units and titrated on fat absorption. "Soy stops Creon working" overstates the ceiling by the whole therapy and is retired.

Why a constraint survives at all — and it is not enzyme inactivation: a large active STI load removes luminal-protease feedback and raises CCK → pancreatic stimulation. Wrong direction for a post-Frey pancreas. Requires raw-flour-scale exposure.

Yardstick — 🔴 NOW HISTORICAL ⟨C·8-15⟩: NaturDAO ~96 mg/day legume protein was cleared. That product left the regimen 8/15 and its porcine replacement carries ZERO legume protein — the number survives as the highest legume exposure this regimen has cleared in practice, but it is no longer a live intake. Erinamax ≈5 µg/day upper bound = ~19,000× below that.

🏷 Provenance ⟨?⟩ — untagged in every rev, no source anywhere in the document, no soy interaction on the Creon FDA label, and none of the cited literature touches PERT, EPI or fat absorption. It was the only Standing Constraint that explained itself instead of citing something. Origin unrecalled — not assumed in either direction.

Call the team — not a supplement question

Dark or tarry stool · visible blood · new dizziness · resting HR climbing · fever or rigors · any BP reading ≥180/120 → urgent care, not a message

Clinical interpreter note

The regimen produces atypically suppressed inflammatory markers (WBC, CRP). Clinical suspicion outweighs standard lab thresholds when assessing acute infection, cholangitis, or pancreatitis flare. A normal white count does not exclude infection in this patient.

What the audits did not find

The regimen was never on trial

Adversarial passes have lodged zero findings against the chronic core. Not one of the ~40 compounds was faulted on evidence quality, dose, timing, interaction, or sourcing — outside the post-surgical window. What gets corrected are the overlays, the instruments, and the reasoning — all of which sit around the regimen, not in it. This rev is one more of those: a stated rationale was wrong; the compound stayed.

The record: GMI 5.7–5.8% across 180 days · zero readings above 250 · eGFR 112 · normal hepatic function despite an obstruction history · HbA1c 6.1% in T3c diabetes, without insulin.

Master Regimen · v6.30 / rev 7.63 · 2026-09-04
Supersedes rev 7.27 — 7.28 through 7.31 were built and never deployed. Eating window resumed noon → 8:30 PM; morning bite cut; NAC bolus at the 8 PM dessert, target 3,300.
Agmatine reinstated 8/6 on stated benefit — not on the burden rule. L-Citrulline, Chromium and 🆕 Grape Seed cut. 🆕 Turkey Tail restored to Meal 1 + Dinner at 500 mg × 2.
Supplement-layer decisions rest with Nate. Clinical-status + prescribed-med changes are the care team's.