Post-Frey recovery · live window 7/22 → 8/1 · canonical IF returns ~Aug 1
The Infini-B line called active B6 "the DAO cofactor." It isn't — that was eliminated in the late 1980s. DAO is a copper amine oxidase; PLP is the cofactor for the enzyme that makes histamine. No dose amount changed this rev. One dose moved in time. The real DAO levers are now named.
DAO (diamine oxidase) is the histamine-degrading enzyme. Its cofactors are copper · calcium · topaquinone (TPQ) — not B6. Ranked for this phenotype, the real levers are:
1. Substrate competition — Agmatine 1 g/day is a confirmed DAO substrate (moved to 4 PM to clear the NaturDAO collision). · 2. Mucosal integrity — DAO is made by gut-lining cells; post-Frey + ulcers + EPI is the likely suppressor. Intervention already live: L-Glutamine 15 g/day. · 3. Copper — the actual metal cofactor, now added to the 8/1 draw.
⚠ B6 is not a DAO lever — it's upstream on histamine synthesis (histidine decarboxylase). Do not switch to NaturDAO Plus: it bundles P5P on the same retired rationale.
Acetaminophen — documented adverse, VM July 2026 · NSAIDs — ulcer / GI-bleed history · Soy — stops Creon working (SerinAid PS is the exception: lecithin lipid fraction, no trypsin inhibitors) · Potassium supplements — on the ARB
Dark or tarry stool · visible blood · new dizziness · resting HR climbing · fever or rigors · any BP reading ≥180/120 → urgent care, not a message
The regimen produces atypically suppressed inflammatory markers (WBC, CRP). Clinical suspicion outweighs standard lab thresholds when assessing acute infection, cholangitis, or pancreatitis flare. A normal white count does not exclude infection in this patient.
Adversarial passes have lodged zero findings against the chronic core. Not one of the ~40 compounds was faulted on evidence quality, dose, timing, interaction, or sourcing — outside the post-surgical window. What gets corrected are the overlays, the instruments, and the reasoning — all of which sit around the regimen, not in it. This rev is one more of those: a stated rationale was wrong; the compound stayed.
The record: GMI 5.7–5.8% across 180 days · zero readings above 250 · eGFR 112 · normal hepatic function despite an obstruction history · HbA1c 6.1% in T3c diabetes, without insulin.