Post-Frey recovery · live window 7/22 → 8/1 · canonical IF returns ~Aug 1
The postprandial fall was max-fasted minus min-postprandial across different days. Paired, every day runs the other way: +3.4 mmHg. Pulse pressure has dropped 69.7 → 54.3, which is exactly what the anemia hypothesis predicted. No dose amount changed. One supplement moved slot.
DAO (diamine oxidase) is the histamine-degrading enzyme. Its cofactors are copper · calcium · topaquinone (TPQ) — not B6. Ranked for this phenotype, the real levers are:
1. Substrate competition — Agmatine 1 g/day is a confirmed DAO substrate (moved to 4 PM to clear the NaturDAO collision). · 2. Mucosal integrity — DAO is made by gut-lining cells; post-Frey + ulcers + EPI is the likely suppressor. Intervention already live: L-Glutamine 15 g/day. · 3. Copper — the actual metal cofactor, now added to the 8/1 draw.
⚠ B6 is not a DAO lever — it's upstream on histamine synthesis (histidine decarboxylase). Do not switch to NaturDAO Plus: it bundles P5P on the same retired rationale.
Acetaminophen — documented adverse, VM July 2026 · NSAIDs — ulcer / GI-bleed history · Soy — stops Creon working (SerinAid PS is the exception: lecithin lipid fraction, no trypsin inhibitors) · Potassium supplements — on the ARB
Dark or tarry stool · visible blood · new dizziness · resting HR climbing · fever or rigors · any BP reading ≥180/120 → urgent care, not a message
The regimen produces atypically suppressed inflammatory markers (WBC, CRP). Clinical suspicion outweighs standard lab thresholds when assessing acute infection, cholangitis, or pancreatitis flare. A normal white count does not exclude infection in this patient.
Adversarial passes have lodged zero findings against the chronic core. Not one of the ~40 compounds was faulted on evidence quality, dose, timing, interaction, or sourcing — outside the post-surgical window. What gets corrected are the overlays, the instruments, and the reasoning — all of which sit around the regimen, not in it. This rev is one more of those: a stated rationale was wrong; the compound stayed.
The record: GMI 5.7–5.8% across 180 days · zero readings above 250 · eGFR 112 · normal hepatic function despite an obstruction history · HbA1c 6.1% in T3c diabetes, without insulin.